Highly Efficient Year-Round Energy and Comfort Optimization of HVAC Systems in Electric City Buses

In this paper, we present a novel approach to perform highly efficient numerical simulations of the heating, ventilation, and air-conditioning (HVAC) system of an electric city bus. The models for this simulation are based on the assumption of a steady-state operation. We show two approaches to obtain the minimum energy requirement for a certain thermal comfort criterion under specific ambient conditions. Due to the computationally efficient approach developed, we can evaluate the model on a large dataset of 7500 scenarios in various ambient conditions to estimate the year-round performance of the system subject to different comfort requirements. Compared to a heating strategy based on positive temperature coefficient (PTC) elements, we can thus show that a heat pump (HP) can reduce the annual mean power consumption by up to 60%. Ceiling-mounted radiant heating elements complementing a PTC heating system can reduce the annual mean power consumption by up to 10%, while they cannot improve the energy efficiency when used in conjunction with a HP. Finally, a broad sensitivity study reveals the fact that improving the HP's heating-mode coefficient of performance (COP) manifests the largest leverage in terms of mean annual power consumption. Moreover, the annual energy expenditure for cooling are around eight times smaller than those for heating. The case study considered thus reveals that the advantages of improving the COP of the cooling mode are significantly lower.Comment: This work has been accepted to IFAC for publication under a Creative Commons Licence CC-BY-NC-N

Polyhedra in loop quantum gravity

Interwiners are the building blocks of spin-network states. The space of intertwiners is the quantization of a classical symplectic manifold introduced by Kapovich and Millson. Here we show that a theorem by Minkowski allows us to interpret generic configurations in this space as bounded convex polyhedra in Euclidean space: a polyhedron is uniquely described by the areas and normals to its faces. We provide a reconstruction of the geometry of the polyhedron: we give formulas for the edge lengths, the volume and the adjacency of its faces. At the quantum level, this correspondence allows us to identify an intertwiner with the state of a quantum polyhedron, thus generalizing the notion of quantum tetrahedron familiar in the loop quantum gravity literature. Moreover, coherent intertwiners result to be peaked on the classical geometry of polyhedra. We discuss the relevance of this result for loop quantum gravity. In particular, coherent spin-network states with nodes of arbitrary valence represent a collection of semiclassical polyhedra. Furthermore, we introduce an operator that measures the volume of a quantum polyhedron and examine its relation with the standard volume operator of loop quantum gravity. We also comment on the semiclassical limit of spinfoams with non-simplicial graphs.Comment: 32 pages, many figures. v2 minor correction

Pruning Algorithms for Pretropisms of Newton Polytopes

Pretropisms are candidates for the leading exponents of Puiseux series that represent solutions of polynomial systems. To find pretropisms, we propose an exact gift wrapping algorithm to prune the tree of edges of a tuple of Newton polytopes. We prefer exact arithmetic not only because of the exact input and the degrees of the output, but because of the often unpredictable growth of the coordinates in the face normals, even for polytopes in generic position. We provide experimental results with our preliminary implementation in Sage that compare favorably with the pruning method that relies only on cone intersections.Comment: exact, gift wrapping, Newton polytope, pretropism, tree pruning, accepted for presentation at Computer Algebra in Scientific Computing, CASC 201

Shadoo (Sprn) and prion disease incubation time in mice

Prion diseases are transmissible neurodegenerative disorders of mammalian species and include scrapie, bovine spongiform encephalopathy (BSE), and variant Creutzfeldt-Jakob disease (vCJD). The prion protein (PrP) plays a key role in the disease, with coding polymorphism in both human and mouse influencing disease susceptibility and incubation time, respectively. Other genes are also thought to be important and a plausible candidate is Sprn, which encodes the PrP-like protein Shadoo (Sho). Sho is expressed in the adult central nervous system and exhibits neuroprotective activity reminiscent of PrP in an in vitro assay. To investigate the role of Sprn in prion disease incubation time we sequenced the open reading frame (ORF) in a diverse panel of mice and saw little variation except in strains derived from wild-trapped mice. Sequencing the untranslated regions revealed polymorphisms that allowed us to carry out an association study of incubation period in the Northport heterogeneous stock of mice inoculated with Chandler/RML prions. We also examined the expression level of Sprn mRNA in the brains of normal and prion-infected mice and saw no correlation with either genotype or incubation time. We therefore conclude that Sprn does not play a major role in prion disease incubation time in these strains of mice

Stratospheric influence on the winter North Atlantic storm track in subseasonal reforecasts

Extreme stratospheric polar vortex events, such as sudden stratospheric warmings (SSWs) or extremely strong polar vortex events, can have a significant impact on surface weather in winter. SSWs are most often associated with negative North Atlantic Oscillation (NAO) conditions, cold air outbreaks in the Arctic and a southward-shifted midlatitude storm track in the North Atlantic, while strong polar vortex events tend to be followed by a positive phase of the NAO, relatively warm conditions in the extratropics and a poleward-shifted storm track. Such changes in the storm track position and associated extratropical cyclone frequency over the North Atlantic and Europe can increase the risk of extreme windstorm, flooding or heavy snowfall over populated regions. Skillful predictions of the downward impact of stratospheric polar vortex extremes can therefore improve the predictability of extratropical winter storms on subseasonal timescales. However, there exists a strong inter-event variability in these downward impacts on the tropospheric storm track. Using ECMWF reanalysis data and reforecasts from the Subseasonal to Seasonal (S2S) Prediction Project database, we investigate the stratospheric influence on extratropical cyclones, identified with a cyclone detection algorithm. Following SSWs, there is an equatorward shift in cyclone frequency over the North Atlantic and Europe in reforecasts, and the opposite response is observed after strong polar vortex events, consistent with the response in reanalysis. However, although the response of cyclone frequency following SSWs with a canonical surface impact is typically captured well during weeks 1–4, less than 25 % of the reforecasts manage to capture the response following SSWs with a “non-canonical” impact. This suggests a possible overconfidence in the reforecasts with respect to reanalysis in predicting the canonical response after SSWs, although it only occurs in about two-thirds of the events. The cyclone forecasts following strong polar vortex events are generally more successful. Understanding the role of the stratosphere in subseasonal variability and predictability of storm tracks during winter can provide a key for reliable forecasts of midlatitude storms and their surface impacts.</p

Incunabular Immunological Events in Prion Trafficking

While prions probably interact with the innate immune system immediately following infection, little is known about this initial confrontation. Here we investigated incunabular events in lymphotropic and intranodal prion trafficking by following highly enriched, fluorescent prions from infection sites to draining lymph nodes. We detected biphasic lymphotropic transport of prions from the initial entry site upon peripheral prion inoculation. Prions arrived in draining lymph nodes cell autonomously within two hours of intraperitoneal administration. Monocytes and dendritic cells (DCs) required Complement for optimal prion delivery to lymph nodes hours later in a second wave of prion trafficking. B cells constituted the majority of prion-bearing cells in the mediastinal lymph node by six hours, indicating intranodal prion reception from resident DCs or subcapsulary sinus macrophages or directly from follicular conduits. These data reveal novel, cell autonomous prion lymphotropism, and a prominent role for B cells in intranodal prion movement

The Comprehensive Native Interactome of a Fully Functional Tagged Prion Protein

The enumeration of the interaction partners of the cellular prion protein, PrPC, may help clarifying its elusive molecular function. Here we added a carboxy proximal myc epitope tag to PrPC. When expressed in transgenic mice, PrPmyc carried a GPI anchor, was targeted to lipid rafts, and was glycosylated similarly to PrPC. PrPmyc antagonized the toxicity of truncated PrP, restored prion infectibility of PrPC-deficient mice, and was physically incorporated into PrPSc aggregates, indicating that it possessed all functional characteristics of genuine PrPC. We then immunopurified myc epitope-containing protein complexes from PrPmyc transgenic mouse brains. Gentle differential elution with epitope-mimetic decapeptides, or a scrambled version thereof, yielded 96 specifically released proteins. Quantitative mass spectrometry with isotope-coded tags identified seven proteins which co-eluted equimolarly with PrPC and may represent component of a multiprotein complex. Selected PrPC interactors were validated using independent methods. Several of these proteins appear to exert functions in axomyelinic maintenance