Control of Particle Size and Porosity in Continuous Fluidized-Bed Layering Granulation Processes

Particle formulation processes such as continuous fluidized‐bed layering granulation (FBLG) are widely applied in chemical, food, and pharmaceutical industries. Particle size and particle porosity are important product properties in FBLG. In this paper, a new concept is presented for the simultaneous control of both properties. The new concept allows stable process operation, automatic adjustment of the desired product properties, and rejection of unforseen disturbances

Investigation of spray agglomeration process in continuously operated horizontal fluidized bed

[EN] Spray fluidized bed agglomeration is an important process in particle formation and is widely used in the chemical, pharmaceutical and food industry. In this study a continuously operated horizontal fluidized bed is employed to obtain a continuous agglomeration process. It is conducted with glass beads (dst=200 µm) and water-based binder hydroxy-propyl-methyl-cellulose (HPMC) sprayed by three top nozzles. The steady state is reached and samples are taken periodically and analyzed. The influence of fluidization air temperature and configurations of internal weirs are studied.The authors gratefully acknowledge the funding of this work by the China Scholarship Council (NO. 201608130097).Du, J.; Bück, A.; Tsotsas, E. (2018). Investigation of spray agglomeration process in continuously operated horizontal fluidized bed. En IDS 2018. 21st International Drying Symposium Proceedings. Editorial Universitat Politècnica de València. 1855-1862. https://doi.org/10.4995/IDS2018.2018.7809OCS1855186