Microinfiltracao de ionomero de vidro de alta viscosidade e carbômero de vidro com e sem revestimento antes e depois de envelhecimento hidrotermal

Objective: The objective of this study was to evaluate the microleakage patterns of GIC and GGC with and without their protective surface coatings on enamel and dentin margins before and after aging. Material and Methods: Two rectangular cavities (height: 2 mm; width: 3 mm; depth: 1.5 mm) were prepared on each tooth at the cemento-enamel junction were prepared on human permanent molars (N=56) and the teeth were randomly assigned to be restored with one of the following: a) high viscosity glass-ionomer cement (GIC) (EQUIA Fil, C Corp., Tokyo, Japan) (n=28), b) glass-carbomer cement (GCC) (Glass Carbomer Products, Leiden, The Netherlands) (n=28). Half of the teeth were further divided into two groups where one group received protective surface coating (SC) (G-Coat Plus, GC Corp) (n=14) and the other group did not (n=14). Half of the teeth were stored for 24 hours (n=7), and the other half was thermocycled (5000 cycles, 5-55°C) (n=7). For microleakage analysis, the teeth were immersed in 5% methylene blue dye for 24 hours, sectioned into two equal halves. Microleakage patterns were evaluated using stereomicroscope and scored on a scale of 0-3 (0: No dye penetration, 1: Dye penetration less than half of the axial wall, 2: Dye penetration more than half the axial wall, 3: Dye penetration spreading along the axial wall). Data were analyzed using Kruskal-Wallis tests at the significance level of 0.05. Results: Compared to 24 h storage, after thermocycling, coating on GIC decreased microleakage significantly compared to GCC (p=0.046) but not for GCC. In the thermocycled groups, coated GIC showed significantly less leakage at the enamel margin but no significant difference was found with both GIC and GCC in the dentin margins. Conclusion: The application of surface coating significantly reduced the microleakage scores of GIC but not GCC, within the enamel margins only.Objetivo: O objetivo deste estudo foi avaliar os padrões de microinfiltração de GIC e GGC com e sem seus revestimentos protetores superficiais nas margens de esmalte e dentina antes e após o envelhecimento. Material e Métodos: duas cavidades retangulares (altura: 2 mm; largura: 3 mm; profundidade: 1,5 mm) foram preparadas em cada dente na junção cemento-esmalte de molares permanentes humanos (N = 56), sendo aleatoriamente designados para serem restaurados com um dos seguintes: a) cimento de ionômero de vidro (GIC) de alta viscosidade (EQUIA Fil, C Corp., Tóquio, Japão) (n = 28), b) cimento de vidrocarbômero (GCC) Carbomer Products, Leiden, Holanda) (n = 28). Metade dos dentes foram divididos em dois grupos, onde um grupo recebeu revestimento protetor de superfície (SC) (G-Coat Plus, GC Corp) (n = 14) e o outro grupo não (n = 14). Metade dos dentes foram armazenados por 24 horas (n = 7), e a outra metade foi termociclada (5000 ciclos, 5-55 ° C) (n = 7). Para análise de microinfiltração, os dentes foram imersos em corante azul de metileno a 5% por 24 horas, seccionados em duas metades iguais. Os padrões de microinfiltração foram avaliados usando estereomicroscópio e pontuados numa escala de 0-3 (0: Sem penetração de corante; 1: penetração de corante inferior à metade da parede axial; 2: penetração de corante mais do que metade da parede axial; 3: penetração de corante ao longo da parede axial). Os dados foram analisados pelo teste de Kruskal-Wallis ao nível de significância de 0,05. Resultados: em comparação com o armazenamento de 24 h, após a termociclagem, o revestimento de superfície no GIC diminuiu significativamente a microinfiltração em comparação com o GCC (p = 0,046), mas não para o GCC. Nos grupos termociclados, o GIC revestido apresentou significativamente menos infiltração na margem do esmalte, mas não houve diferença significativa para o GIC e o GCC nas margens dentinárias. Conclusão: A aplicação do revestimento de superfície reduziu significativamente os escores de microinfiltração do GIC, mas não do GCC, apenas nas margens do esmalte

Marfan Sendromunda Dental Bulgular: Olgu Sunumu

WOS:000408113700010PubMed ID: 28955598Marfan sendromu, öncelikle kas-iskelet sistemi, kalp-damar sistemi ve gözleri etkileyen anomaliler ile karakterize, otozomal dominant bir bağ dokusu hastalığıdır. Enfektif endokardit riski nedeniyle sendromun erken tanısının önemli olduğu ileri sürülmektedir. 7 yaşındaki kadın hasta alt çenenin ön bölgesindeki dişlerin çapraşıklığı şikâyeti ile kliniğimize başvurdu. Ayrıntılı klinik ve radyografik muayene sonucu hastanın çoklu tedavi ihtiyacı olduğu belirlendi. Hastanın derin çürükleri dikkate tedaviler girişimden bir saat önce olacak şekilde tasarlanan antibiyotik proflaksisi altında gerçekleştirildi. Hastaya diş hekimine düzenli olarak gelmesi önerildi ve ortodontik değerlendirilmeye yönlendirildiMarfan syndrome is an autosomal dominant disorder of connective tissue primarily characterized with anomalies affecting the musculoskeletal system, the cardiovascular system and the eyes. It has been suggested that early diagnosis of the syndrome is important, because of the risk of infective endocarditis. A 7-year-old female was referred to our clinic, with a chief complaint of dental crowding in the anterior region of mandible. It was observed that the patient needed multiple treatments based on detailed clinical and radiographic examinations. The treatment was carried out with antibiotic prophylaxis an hour prior to her appointment considering her profound caries. The patient was advised to visit regularly for follow up and she was referred for orthodontic evaluatio

DENTAL FINDINGS IN MARFAN SYNDROME: A CASE REPORT

Marfan syndrome is an autosomal dominant disorder of connective tissue primarily characterized with anomalies affecting the musculoskeletal system, the cardiovascular system and the eyes. It has been suggested that early diagnosis of the syndrome is important, because of the risk of infective endocarditis. A 7-year-old female was referred to our clinic, with a chief complaint of dental crowding in the anterior region of mandible. It was observed that the patient needed multiple treatments based on detailed clinical and radiographic examinations. The treatment was carried out with antibiotic prophylaxis an hour prior to her appointment considering her profound caries. The patient was advised to visit regularly for follow up and she was referred for orthodontic evaluation

Design, Synthesis Molecular Docking Study and Antifungal Activity Evaluation of New Benzimidazole-Triazole Derivatives

Lanosterol 14α-demethylase (CYP51) is an essential enzyme in the fungal life cycle and also an important target for antifungal drug development. Selective inhibition of the enzyme would cause depletion of ergosterol and accumulation of lanosterol and result in the growth inhibition of the fungal cell [1]. [...

Adams-Olıver Syndrome: a Case Report

Background: Adams-Oliver Syndrome has been described by Adams and Oliver in 1945. Original definition, along with aplasia cutis congenital syndrome and limb defects, has neurological and cardiological problems. In the first description, genetic defect passes variable autosomal dominant pattern. Afterwards the autosomal recessive and sporadic cases were published

Design, Synthesis and Biological Evaluation of Novel N-Pyridyl-Hydrazone Derivatives as Potential Monoamine Oxidase (MAO) Inhibitors

A new series of N-pyridyl-hydrazone derivatives was synthesized by using a simple and efficient method. The final compounds obtained were screened for their inhibitory potency against monoamine oxidase (MAO) A and B. The newly synthesized compounds 2a–2n specifically inhibited monoamine oxidases, displaying notably low IC50 values. Compounds 2i and 2j, with a CF3 and OH group on the 4-position of the phenyl ring, respectively, showed considerable MAO-A and MAO-B inhibitory activities. Compounds 2k, 2l and 2n, with N-methylpyrrole, furan and pyridine moieties instead of the phenyl ring, were the most powerful and specific inhibitors of MAO-A, with IC50 values of 6.12 μM, 10.64 μM and 9.52 μM, respectively. Moreover, these active compounds were found to be non-cytotoxic to NIH/3T3 cells. This study supports future studies aimed at designing MAO inhibitors to obtain more viable medications for neurodegenerative disorders, such as Parkinson’s disease

Synthesis and Biological Evaluation of New Cholinesterase Inhibitors for Alzheimer’s Disease

Alzheimer’s disease (AD) is a neurodegenerative disorder mostly influencing the elderly, and causes death due to dementia. The main pathogenic feature connected with the progression of this multifactorial disease is the weakening of the cholinergic system in the brain. Cholinesterase (ChE) inhibitors are recognized as one of the choices in the treatment of AD. The inhibition of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) were approved as a therapeutic strategy to reduce the symptoms of AD and prevent its progression. The capacity of BChE is not completely known yet; rather, it is accepted to assume a part in a few disorders such as AD. Thus, BChE inhibitors may have a greater role for the treatment of AD in the future. In the present study, 2-(9-acridinylamino)-2-oxoethyl piperazine/piperidine/morpholinecarbodithioate derivatives were synthesized in order to investigate anticholinesterase activity. Eight derivatives demonstrated a specific and promising action against BChE. Furthermore, compound 4n showed inhibitory activity against both enzymes. It was found that the active compounds were well tolerated in the cytotoxicity test. Possible interactions between the lead compound, 4n, and the BChE enzyme were determined through a docking study. The findings obtained within this paper will contribute to the development of new and effective synthetic anti-Alzheimer compounds, and will ideally encourage future screening against AD