The Importance of Inflammatory Markers in Predicting Chronic Venous Insufficiency

Objective: Chronic venous insufficiency can be missed unless it comes to mind. We need a simplified diagnosis of chronic venous insufficiency. This study is aimed to analyze the potential role of inflammatory markers like monocyte count/high-density lipoprotein cholesterol on the diagnosis of chronic venous insufficiency. Methods: This is a retrospective study. A total of 419 patients admitted to our clinics between September 1, 2019, and January 20, 2021, were included. Blood tests and venous Duplex ultrasound examinations applied to lower limb veins on the same day were studied. Monocyte count/high-density lipoprotein cholesterol was measured. A reflux time longer than 1 second in Duplex ultrasonography was considered venous insufficiency. The patients were divided into 2 groups according to the presence or absence of venous insufficiency. The relation between these results and the presence of venous insufficiency was examined. Results: When compared with the patients without venous insufficiency, monocyte count was higher (0.61 ± 0.18 vs. 0.55 ± 0.15 109 /L; P = .00) and high-density lipoprotein cholesterol was found to be lower (49 ± 9.1 vs. 53.4 ± 13.6 mg/dL; P = .02) in the patients with chronic venous insufficiency. The monocyte count to high-density lipoprotein cholesterol ratio was higher in the patients with chronic venous insufficiency (12.5 ± 5 vs. 10.9 ± 4; P = .005). According to multivariate regression analysis, monocyte count (95% CI: 1.003-1.035; P = .020) and monocyte count to high-density lipoprotein cholesterol ratio (95% CI: 1.017-1.154; P = .013) were independent risk factors for the occurrence of venous insufficiency. Conclusions: If the monocyte count to high-density lipoprotein cholesterol ratio is high, it may be predicted that this patient may have chronic venous insufficiency. This prediction may focus us on the lower extremity examination in clinical routine practice

Treatment and follow-up results of children with electrical burn who observed in burn intensive care unit

Electrical burns are infrequent relative to other injuries, but they are associated with high morbidity and mortality. The aim of this study was to assess management and follow-up results of pediatric patients’ who observed in intensive care unit and also review the precautions for preventing electrical burns.Materials and methods: Totally 22 patients aged under 17 years who were observed in the burn intensive care unit of Şanlıurfa Education and Research Hospital during the period between July 2009-October 2010. Cases were investigated retrospectively. The patients’ age, gender, total burn surface area, length of stay in hospital, musculo-skeletal system complication, cardiovascular system complication, kidney damage and attempts were recorded.Results: Of the 22 cases, 19 (86.3%) were male and 3 (13.7%) were female. The mean age of the patients was 11.5 years. In 10 (45.4%) children burns were occurred in workplace and working area and 12 (54.6%) were occurred in the home environment. Depth of burns were third degree in 10 (45.4%) children and second degree in 12 (54.6%). The mean percentage of burn surface area was 25.9%. The mean length of stay in hospital was 17 days. Debridement and grafting were performed to 12 (54.6%) cases and 10 (45.4%) children were treated with dressings. No patient had increased creatinine kinase levels, oliguria, myoglobuinuria and arrhythmia. The mean hospitalization time was 17 days.Conclusion: Nearly half of patients underwent debridement plus grafting. None of our patients developed renal failure other severe system dysfunction

The Relationship Between the Frontal QRS-T Angle and High Blood Pressure Response to Exercise

Introduction:In this study, we compared frontal QRS-T angles between normotensive subjects with high blood pressure (BP) respons to exercise test and the control group.Methods:Patients who were scheduled for an exercise test between January 2017 and January 2022 were included in the study. The patient group consisted of people who responded to the exercise test with elevated BP, and the control group included people who responded to the exercise test with normal BP. The data in the electrocardiography device’s report section was used to calculate the QRS and T-axis. The frontal QRS-T angle was identified as the absolute difference between these two axes.Results:Frontal QRS-T angles were found to be significantly higher in the patient group compared with the control group (36.09±14.51 and 20.46±8.12; p<0.001). In multivariate analysis, frontal QRS-T angles were found to be an independent predictor of higher BP response to exercise test [odds ratio: 1,189, 95% confidence interval (CI); 1,083-1,305; p<0.001]. Receiver operating characteristic curve analysis showed that the frontal QRS-T angle value predicting an excessive BP response to exercise test was 27.5º with a sensitivity of 71% and a specificity of 75% (area under the curve: 0.832; 95% CI: 0.75-0.91; p<0.001).Conclusion:The frontal QRS-T angles were found to be significantly higher in the group that gave higher BP response to the exercise test compared to the control group. Patients with a high BP response to exercise test can be detected using the frontal QRS-T angle before the test

The potential role of BMI, plasma leptin, nesfatin-1 and ghrelin levels in the early detection of pancreatic necrosis and severe acute pancreatitis: A prospective cohort study

AbstractBackground: Early prediction of disease severity in acute pancreatitis (AP) is crucial. The aim of this study was to investigate the body-mass index (BMI), plasma leptin, nesfatin-1 and ghrelin levels as potential markers predicting peripancreatic necrosis and severity in acute pancreatitis. Methods: In the study period, 97 consecutive patients with AP were prospectively analysed. Severe AP was defined according to the Atlanta Criteria. BMI was also calculated. To measure plasma Leptin, Nesfatin-1 and Ghrelin concentrations, the blood samples were obtained from patients within 24 hours of admission. Results: Out of 97 patients, 92(70 females, 22 males) were considered eligible for analysis. Of the 92 patients, 30 patients (32.6%) were assessed as severe pancreatitis. BMI and leptin levels were significantly higher in patients with severe pancreatitis. The pooled sensitivity and specificity of BMI as a predictor for the development of pancreatic necrosis were 0.90(95%CI = 0.56–0.99) and 0.70(95%CI = 0.58–0.79), respectively; with an overall area under curve value of 0.78.The pooled sensitivity and specificity of leptin levels as a predictor for development of pancreatic necrosis were 1(95%CI = 0.69–1) and 0.73(95%CI = 0.62–0.82),respectively; with an overall area under curve value of 0.82.Nesfatin-1 and ghrelin levels showed no significant difference in patients with mild pancreatitis (6.97 ± 0.84 ng/ml and 2.3(1.0–9.9);respectively) and severe pancreatitis (6.74 ± 0.65 ng/ml and 2.0(1.9–9.9); respectively) (p = 0.1923 and 0.8531;respectively). Conclusion: BMI and plasma leptin levels both were correlated with the severity of pancreatitis. Leptin levels showed better area under the curve, sensitivity and specificity values compared to BMI in prediction of pancreatic necrosis.Nesfatin-1 and ghrelin levels were not found to be predictors of the severity of disease

Risk Factors for Atrial Fibrillation Recurrence in Patients Undergoing Ablation

Aim:The current study aimed to investigate the predictors of recurrence in patients with paroxysmal atrial fibrillation (AF) undergoing cryoballoon ablation.Materials and Methods:This study was conducted with the participation of the patients who underwent cryoballoon ablation between October 2013 and March 2016. Patients’ medical records were retrospectively evaluated. Patients were divided into two groups as those with AF recurrence and those without AF recurrence.Results:A total of 68 patients undergoing cryoballoon ablation were included in the study. The mean age of the patients was 57.3±12 years, and 32% were male. Concomitant conditions included coronary artery disease in 25 patients (36.8%), diabetes mellitus in 9 (13.2%), hypertension in 46 (67.6%), and history of cerebrovascular event in 3 (4.4%). During the early period involving the initial three months, AF recurrence was found in 16 patients (23.5%), while 52 (76.5%) remained in the sinus rhythm during the follow-up. There were significant differences between two groups in left atrium size (38±5.3 and 44±6.6, p=0.003), left atrial appendage (LAA) flow rate [38 (24-62) cm/sec and 28 (22-55) cm/sec, p=0.001], presence of pulmonary venous anomaly [5 (9.6%) and 6 (37.5%), p=0.016], the number of antiarrhythmic drugs before the ablation (1.78±0.7 and 2.43±0.5, p=0.002), interventricular septal thickness (11±1.7 mm and 12±1.47 mm, p=0.008), left ventricular posterior wall thickness (11±0.9 mm and 12±1.3 mm, p=0.007), and left ventricular mass (195±51 g and 181±37.9 g, p=0.028).Conclusion:According to the results, AF recurrence after ablation was found to be associated with the use of multiple antiarrhythmic drugs before the ablation, increased left atrial diameter, the reduced flow rate in the LAA, presence of a pulmonary venous anomaly, increased interventricular septal thickness, left ventricular posterior wall thickness, and left ventricular mass

Investigation of antioxidant effects of rosmarinic acid on liver, lung and kidney in rats: a biochemical and histopathological study

Background: The aim of the study was to investigate the protective effects of rosmarinic acid in rats exposed to hepatic ischaemia/reperfusion (I/R) injury. Materials and methods: Thirty-two rats were randomly classified into four groups of 8 rats each: laparotomy without medication, rosmarinic acid (dose of 50 mg/kg via oral gavage) followed by laparotomy, laparotomy followed by hepatic I/R, and hepatic I/R with rosmarinic acid. Serum aspartate aminotransferase, alaninę aminotransferase, and malondialdehyde levels and total oxidant activity and total antioxidant capacity levels of the liver, lung, and kidney were assessed. The histopathologic assessment was also performed. Results: Rosmarinic acid significantly reduced liver function test parameters and decreased oxidative stress and abnormal histopathologic findings in the liver. The oxidative stress in the lung significantly increased in the I/R group but significantly decreased in the I/R + rosmarinic acid group due to the addition of rosmarinic acid. Rosmarinic acid led to no reduction in oxidative stress in kidney following hepatic I/R injury. There were no statistically significant differences among the groups regarding histopathologic changes in kidney and lung sections. Conclusions: Rosmarinic acid has antioxidant properties and is an effective hepatoprotective agent. However, although rosmarinic acid provides useful effects in the lung by increasing antioxidant capacity and reducing oxidative stress after I/R injury, it does not ameliorate histopathologic changes. These findings suggest that rosmarinic acid is likely to provide favourable outcomes in the treatment of hepatic I/R injury

Tip 2 diyabetes mellituslu hastalarda C peptid ile mikroalbuminüri ilişkisi

Purpose: Latest studies suggest that C-peptide may have a beneficial biological role on diabetic nephropathy. The aim of this study is to analyze whether there is an association between serum C-peptide level and microalbuminuria in type 2 diabetes mellitus (T2DM). Materials and Methods: We enrolled 184 T2DM patents and 46 healthy subjects in this study. Clinical variables and routine biochemical tests along with serum C peptide levels measured after an overnight fasting. Serum C peptide levels between 1.1 and 4.4 accepted as normal. 24hour-urine samples were investigated and values between 30-300mgwere recorded as microalbuminuria. Pearson correlation analysis were used to determine associations between continuous variables. Results: C peptide levels were not significantly difference in T2DM patients compared to healthy controls. Serum C peptide levels showed positive correlation with ins&uuml;lin and microalbminuria with the Pearson correlation analysis. However, there was no significant association between other variables and C peptide levels. Conclusion: A correlation was found between microalbuminuria and serum C-peptide in this present study. Findings suggest C-peptide is related with renal complications of T2DM patients.Amaç: Son dönem çalışmaları C peptitin diyabetik nefropatide yararlı etkileri olduğunu öne sürmektedir. Bu çalışmada tip 2 diyabetes mellitus (T2DM) hastalarında gözlenen mikroalbuminüri ile serum C peptit düzeylerinin ilişkili olup olmadığını analiz etmeyi amaçladık. Gereç ve Yöntem: Bu amaçla 184 tip 2 diyabet hastası ve 46 sağlıklı kontrol çalışmaya alındı. Hastaların klinik özellikleri ve rutin biyokimyasal tetkiklerine ek olarak serum C peptit seviyeleri kaydedildi. Serum C peptit normal aralığı 1.1-4.4 olarak kabul edildi. Hastalardan 24 saatlik idrar toplanarak araştırıldı ve 30-300 mg aralığı mikroalbuminuri olarak kaydedildi. Değişkenler arasındaki ilişkiyi ortaya koymak amacıyla Pearson korelasyon analizi kullanıldı. Bulgular: Tip 2 diyabet hastaları sağlıklı control grubu ile karşılaştırıldığında C peptit düzeyleri arasında anlamlı farklılık saptanmadı. Pearson korelasyon analizinde C peptit düzeyleri, insulin ve mikroalbuminuri arasında pozitif korelasyon olduğu görüldü. Bununla birlikte C -peptit ve diğer değişkenler arasında anlamlı bir ilişki bulunmadı. Sonuç: Bu çalışmada serum C peptit düzeyleri ile mikroalbuminüri varlığının ilişkili olduğunu gösterdik. Bulgular C peptitin T2DM hastalarında renal komplikasyonları ile ilişkili olduğunu ortaya koymaktadır

Ratlarda adacık hücreleri ile kokültüre edilen luteal hücrelerin, hücre canlılığı, revaskülarizasyon ve immun yanıta etkileri

Tez (Doktora) -- Kırıkkale Üniversitesi11673415.02.2020 tarihine kadar yayınlanmayacak.