59 research outputs found
Capacity analysis of an IEEE 802.11n system in a residential house based on estimated specular and dense multipath components
Frame Theory for Signal Processing in Psychoacoustics
This review chapter aims to strengthen the link between frame theory and
signal processing tasks in psychoacoustics. On the one side, the basic concepts
of frame theory are presented and some proofs are provided to explain those
concepts in some detail. The goal is to reveal to hearing scientists how this
mathematical theory could be relevant for their research. In particular, we
focus on frame theory in a filter bank approach, which is probably the most
relevant view-point for audio signal processing. On the other side, basic
psychoacoustic concepts are presented to stimulate mathematicians to apply
their knowledge in this field
Novel peptide calcitonin gene-related peptide antagonists for migraine therapy.
Objectives It has previously been shown that the peptide (34Pro,35Phe)CGRP27-37 is a potent calcitonin gene-related peptide, CGRP receptor antagonist, and in this project we aimed to improve the antagonist potency through the structural modification of truncated C-terminal CGRP peptides. Methods Six peptide analogues were synthesized and the anti-CGRP activity confirmed using both in vitro and in vivo studies. Key findings A 10 amino acid-containing peptide VPTDVGPFAF-NH2 (P006) was identified as a key candidate to take forward for in vivo evaluation, where it was shown to be an effective antagonist after intraperitoneal injection into mice. P006 was formulated as a preparation suitable for nasal administration by spray drying with chitosan to form mucoadhesive microcarriers (9.55 ± 0.91 mm diameter) and a loading of 0.2 mg peptide per 20 mg dose.Conclusions The project has demonstrated the potential of these novel small peptide CGRP antagonists, to undergo future preclinical evaluation as anti-migraine therapeutics
Cyclostationarity-Based and Super-Imposed Pilot-Aided Maximum Doppler Spread Estimation for LOFDM Systems in Doubly-Dispersive Channels
Noxious Heat Threshold Measured with Slowly Increasing Temperatures: Novel Rat Thermal Hyperalgesia Models
- âŠ