Dynamical Formation of Millisecond Pulsars in Globular Clusters

The cumulative luminosity distribution functions (CLFs) of radio millisecond pulsars (MSPs) in globular clusters (GCs) and in the Galactic field at a frequency of 1.4 GHz have been examined. Assuming a functional form, $N \propto L^q$ where $N$ is the number of MSPs and $L$ is the luminosity at 1.4 GHz, it is found that the CLFs significantly differ with a steeper slope, $q=-0.83 \pm 0.05$, in GCs than in the Galactic field ($q=-0.48 \pm 0.04$), suggesting a different formation or evolutionary history of MSPs in these two regions of the Galaxy. To probe the production mechanism of MSPs in clusters, a search of the possible relationships between the MSP population and cluster properties was carried out. The results of an investigation of 9 GCs indicate positive correlations between the MSP population and the stellar encounter rate and metallicity. This provides additional evidence suggesting that stellar dynamical interactions are important in the formation of the MSP population in GCs.Comment: 18 pages, 3 figures, 4 tables, accepted for publication in Ap

Diffuse X-ray emission in globular cluster cores

The unresolved X-ray emission in the cores of 10 globular clusters hosting millisecond pulsars is investigated. Subtraction of the known resolved point sources leads to detectable levels of unresolved emission in the core region of M28, NGC 6440, M62, and NGC 6752. The X-ray luminosities in the 0.3-8 keV energy band of this emission component were found to lie in the range $\sim 1.5 \times 10^{31}$ ergs s$^{-1}$ (NGC 6752) to $\sim 2.2 \times 10^{32}$ ergs s$^{-1}$ (M28). The lowest limiting luminosity for X-ray source detections amongst these four clusters was $1.1 \times 10^{30}$ ergs s$^{-1}$ for NGC 6752. The spectrum of the unresolved emission can be fit equally well by a power-law, a thermal bremsstrahlung model, a black body plus power-law, or a thermal bremsstrahlung model plus black body component. The unresolved emission is considered to arise from the cumulative contribution of active binaries, cataclysmic variables, and faint millisecond pulsars with their associated pulsar wind nebulae. In examining the available X-ray data, no evidence for any pulsar wind nebular emission in globular clusters is found. It is shown that the X-ray luminosity contribution of a faint source population based on an extrapolation of the luminosity function of detected point sources is compatible with the unresolved X-ray emission in the cores of NGC 6440 and NGC 6752. Adopting the same slope for the luminosity function for M62 as for NGC 6440 and NGC 6752 leads to a similar result for M62. For M28, the contribution from faint sources in the core can attain a level comparable with the observed value if a steeper slope is adopted. The characteristics on the faint source population as constrained by the properties of the unresolved X-ray emission are briefly discussed.Comment: 25 pages, 4 figures, 3 tables, accepted for publication in Ap

A combined analysis of outcome following breast cancer: differences in survival based on BRCA1/BRCA2 mutation status and administration of adjuvant treatment

BACKGROUND: The prognostic significance of germline mutations in BRCA1 and BRCA2 in women with breast cancer remains unclear. A combined analysis was performed to address this uncertainty. METHODS: Two retrospective cohorts of Ashkenazi Jewish women undergoing breast-conserving treatment for invasive cancer between 1980 and 1995 (n = 584) were established. Archived tissue blocks were used as the source of DNA for Ashkenazi Jewish BRCA1/BRCA2 founder mutation analysis. Paraffin-embedded tissue and follow-up information was available for 505 women. RESULTS: Genotyping was successful in 496 women, of whom 56 (11.3%) were found to carry a BRCA1/BRCA2 founder mutation. After a median follow-up period of 116 months, breast cancer specific survival was worse in women with BRCA1 mutations than in those without (62% at 10 years versus 86%; P < 0.0001), but not in women with the BRCA2 mutation (84% versus 86% at 10 years; P = 0.76). Germline BRCA1 mutations were an independent predictor of breast cancer mortality in multivariate analysis (hazard ratio 2.4, 95% confidence interval 1.2–4.8; P = 0.01). BRCA1 status predicted breast cancer mortality only among women who did not receive chemotherapy (hazard ratio 4.8, 95% confidence interval 2.0–11.7; P = 0.001). The risk for metachronous ipsilateral cancer was not greater in women with germline BRCA1/BRCA2 founder mutations than in those without mutations (P = 0.68). CONCLUSION: BRCA1 mutations, but not BRCA2 mutations, are associated with reduced survival in Ashkenazi women undergoing breast-conserving treatment for invasive breast cancer, but the poor prognosis associated with germline BRCA1 mutations is mitigated by adjuvant chemotherapy. The risk for metachronous ipsilateral disease does not appear to be increased for either BRCA1 or BRCA2 mutation carriers, at least up to 10 years of follow up

Cashew nut allergy: clinical relevance and allergen characterisation

Cashew plant (Anacardium occidentale L.) is the most relevant species of the Anacardium genus. It presents high economic value since it is widely used in human nutrition and in several industrial applications. Cashew nut is a well-appreciated food (belongs to the tree nut group), being widely consumed as snacks and in processed foods by the majority of world's population. However, cashew nut is also classified as a potent allergenic food known to be responsible for triggering severe and systemic immune reactions (e.g. anaphylaxis) in sensitised/allergic individuals that often demand epinephrine treatment and hospitalisation. So far, three groups of allergenic proteins have been identified and characterised in cashew nut: Ana o 1 and Ana o 2 (cupin superfamily) and Ana o 3 (prolamin superfamily), which are all classified as major allergens. The prevalence of cashew nut allergy seems to be rising in industrialised countries with the increasing consumption of this nut. There is still no cure for cashew nut allergy, as well as for other food allergies; thus, the allergic patients are advised to eliminate it from their diets. Accordingly, when carefully choosing processed foods that are commercially available, the allergic consumers have to rely on proper food labelling. In this sense, the control of labelling compliance is much needed, which has prompted the development of proficient analytical methods for allergen analysis. In the recent years, significant research advances in cashew nut allergy have been accomplished, which are highlighted and discussed in this review.This work was supported by FCT/MEC through national funds and co-financed by FEDER, under the Partnership Agreement PT2020 with grant no. UID/QUI/50006/2013–POCI/01/ 0145/FEDER/007265. Joana Costa is grateful to FCT post-doctoral grant (SFRH/BPD/102404/2014) financed by POPH-QREN (subsidised by FSE and MCTES).info:eu-repo/semantics/publishedVersio

Factors associated with stunting among children according to the level of food insecurity in the household: a cross-sectional study in a rural community of Southeastern Kenya

Background: Chronic malnutrition or stunting among children under 5 years old is affected by several household environmental factors, such as food insecurity, disease burden, and poverty. However, not all children experience stunting even in food insecure conditions. To seek a solution at the local level for preventing stunting, a cross-sectional study was conducted in southeastern Kenya, an area with a high level of food insecurity. Methods: The study was based on a cohort organized to monitor the anthropometric status of children. A structured questionnaire collected information on the following: demographic characteristics, household food security based on the Household Food Insecurity Access Scale (HFIAS), household socioeconomic status (SES), and child health status. The associations between stunting and potential predictors were examined by bivariate and multivariate stepwise logistic regression analyses. Furthermore, analyses stratified by level of food security were conducted to specify factors associated with child stunting in different food insecure groups. Results: Among 404 children, the prevalence of stunting was 23.3%. The percentage of households with severe food insecurity was 62.5%. In multivariative analysis, there was no statistically significant association with child stunting. However, further analyses conducted separately according to level of food security showed the following significant associations: in the severely food insecure households, feeding tea/porridge with milk (adjusted Odds Ratio [aOR]: 3.22; 95% Confidence Interval [95% CI]: 1.43-7.25); age 2 to 3 years compared with 0 to 5 months old (aOR: 4.04; 95% CI: 1.01-16.14); in households without severe food insecurity, animal rearing (aOR: 3.24; 95% CI: 1.04-10.07); SES with lowest status as reference (aOR range: from 0.13 to 0.22). The number of siblings younger than school age was not significantly associated, but was marginally associated in the latter household group (aOR: 2.81; 95% CI: 0.92-8.58). Conclusions: Our results suggest that measures against childhood stunting should be optimized according to food security level observed in each community