Assessment of knowledge and attitude on breast self-examination among female college students at Adichuchanagiri University

Background: Breast self-examination (BSE) is a preventive and easy way for people to keep an eye on the health of their breasts. People who routinely examine their breasts may be able to identify changes or abnormalities at an early stage, which may help in the early diagnosis of breast cancer. This self-care routine encourages an active approach to breast health and actively participate in their own well-being. Objectives of the study were assessment of the knowledge and attitude on breast self-examination among female college students, to assess the major barrier to perform breast self-examination, and to assess the impact of pharmacist mediated education program on breast cancer. Methods: This study is an interventional cross-sectional community based-survey. 1007 students’ female college students at Adichuchanagiri University in B. G. Nagar belonging to 18-33 years were chosen at random using stratified sampling. Knowledge, attitude on breast cancer. Data was analyzed using statistical package for the social science (SPSS) version 25. Results: In pre-test out of 1007 students 251 students had good knowledge about breast self-examination. In post-test 1006 members had good knowledge about breast self-examination. In our study statistical relation found between pre and post questionnaires (p=0.001). Conclusions: The study emphasizes how important it is to launch educational programs to increase awareness of breast self-examination. Additionally, awareness needs to be raised by removing known barriers. It is important to encourage women in the community to self-examine their breasts and to report any changes to a doctor as soon as possible

Utilisation of High Energy Propellant Waste in Manufacturing of Fired Clay Bricks to Enhance the Acoustic Properties

The disposal and waste management of solid high energy propellant (HEP) is a considerate conservational problem. HEP waste is currently disposed in open or confined burning which may cause environmental hazards. In this paper, we examined and discussed results on recycling of HEP waste into fired clay bricks baked in different orientation. HEP modified bricks with 1.5%, 3% and 5 wt. % HEP waste content were manufactured and tested, and then compared against virgin clay bricks without HEP content. The effect of directional orientation of bricks baked with varying HEP content on acoustic properties were experimented and discussed. The sound transmission loss decreases with increase in HEP waste due to formation of independently closed directional pores. The transmission loss of horizontally baked during firing of bricks is nearly 5dB lower than vertically baked bricks. Results of the experimental studies indicate that HEP waste can be utilised in fired clay bricks and different orientation baking further enhances the acoustic properties

SYNTHESIS, CHARACTERIZATION AND IN VITRO ANTIMICROBIAL EVALUATION OF SOME NEW AMIDES OF THIOMORPHOLINE CARBOXYLATE

Objective: Synthesis and antimicrobial evaluation of some new amides of Thiomorpholine caboxylate.Methods: A series of new amides of Thiomorpholine caboxylate were synthesized by reacting 4-tert-butyl 2-methyl thiomorpholine-2,4-dicarboxylate 1,1-dioxide with primary amines in presence of Trimethyl aluminum in toluene at ambient temperature in good yields. 4-tert-butyl 2-methyl thiomorpholine-2,4-dicarboxylate 1,1-dioxide was synthesized by reacting tert-butyl thiomorpholine-4-carboxylate 1,1-dioxide with methyl chloroformate in presence of LiHMDS (1M in THF) at -78oC for the first time. The newly synthesized compounds were characterized by IR, 1HNMR, 13C NMR, Mass spectral studies and elemental analysis.Results: A series of new amides of Thiomorpholine carboxylate were synthesized in good yields and all the compounds were screened for their In-vitro antimicrobial activities. Conclusion: Preliminary results revealed that the synthesized compounds were showed moderate to good antibacterial and antifungal activity

Study on High Energy Propellant Waste in the Processing of Fired Clay Bricks

Utilisation of propellant waste in fabrication of bricks is not only used as efficient waste disposal method but also to get better functional properties. In the present study, high energy propellant (HEP) waste additive mixed with soil and fly ash in different proportions during manufacturing of bricks has been investigated experimentally. X-ray diffraction (XRD) studies were carried out to confirm the brick formation and the effect of HEP waste. Ceramic bricks were fabricated with HEP waste additive in proper proportions i.e. 0.5 wt %, 1.0 wt %, 1.5 wt %, 2.0 wt %, 2.5 wt %, 3 wt %, 3.5 wt %, and 4 wt % and then evaluated for water absorption capability and compressive strength. Compressive strength of 6.7 N/mm2, and Water absorption of 22 % have been observed from modified fired bricks impregnated with HEM waste additive. Scanning electron microscopy (SEM) studies were carried out to analyze the effect of HEP waste additive on pore formation and distribution in the bricks. Further, the heat resulting from decomposition of propellants can cause a decrease in the energy required of baking process. The process of manufacturing of bricks with HEP waste additive is first of its kind till date

Comparison of knowledge and perception about adverse drug reaction reporting and pharmacovigilance between pharmacy and medical students

Background: Adverse drug responses are serious public health issues worldwide. Pharmacovigilance (PV) is an important part of the healthcare system since it assesses, monitors, and discovers medication interactions and their consequences in humans. Objective were to assess knowledge and perception about adverse drug reactions (ADR) and PV among pharmacy and medical students. Methods: A cross-sectional study was conducted for pre-final year and final-year of pharmacy and medical students. Study conducted through semi structured questionnaires and a total 607 participants were recruited in this study. Results: A total 607 participants of pharmacy (52.5%) and medical (47.4%) from pre final (50.2%), final year (49.9%) students participated in this study. Pharmacy students had a significantly better overall knowledge of ADRs than medical students (p<0.05). The perception of pharmacy students regarding ADRs reporting and PV were significantly more than those medical student’s (p<0.05). In comparison to pharmacy students, a lack of knowledge of where and how to report ADRs was the main barrier that medical students perceived to ADR reporting (0.02). Conclusions: This study shows that compared to medical students, pharmacy students had better awareness of ADR reporting and shown good perceptions of PV. To enhance the knowledge of PV among healthcare students, an instructional intervention ought to be implemented

Filarial/Human Immunodeficiency Virus Coinfection in Urban Southern India

The disease course of human immunodeficiency virus (HIV) is often altered by existing or newly acquired coinfections. Treatment or prevention of these concomitant infections often improves the quality and duration of life of HIV-infected persons. The impact of helminth infections on infections with HIV is less clear. However, HIV is frequently most problematic in areas where helminth infections are common. In advance of the widespread distribution of drugs for elimination of lymphatic filariasis, we assessed the prevalence of active Wuchereria bancrofti infection among HIV-positive patients in Chennai, India at two time points separated by four years. We found that the overall prevalence of W. bancrofti infections among HIV-positive persons was 5–9.5%, and there were no quantitative differences in circulating filarial antigen levels between HIV-positive and HIV-negative filarial-infected patients

Adsorption Studies of Congo Red from Aqueous Solution on to Rice Husk

ABSTRACT Adsorption is of significant importance for the effluent treatment, especially for the treatment of colored effluent generated from the dyeing and bleaching industries. Low cost adsorbents have gained attention over the decades as a means of achieving very high removal efficiencies to meet discharge standards. The present paper reports on batch investigations for color removal from aqueous solutions of Congo red (CR) using Rice Husk (RH) as an alternative low cost adsorbent. The performance analysis was carried out as function of various operating parameters, such as initial concentration of dye, adsorbent dose, contact time, particle size of adsorbent and P H . Performance studies revealed that a very high percentage removal of color was achievable. Detailed data analysis indicated that the adsorption of CR followed Freundlich isotherm and Langmuir isotherm

A VALIDATED RP-HPLC METHOD FOR SIMULTANEOUS ESTIMATION OF FEBUXOSTAT AND KETOROLAC TROMETHAMINE IN PHARMACEUTICAL FORMULATIONS

A simple, fast, precise, selective and accurate RP-HPLC method was developed and validated for the simultaneous determination of Febuxostat and Ketorolac from bulk and formulations. Chromatographic separation was achieved isocratically on a Waters C18 column (250×4.6 mm, 5 µ particle size) using a mobile phase, Methanol and Ammonium acetate buffer (adjusted to pH 6.0 with 1% orthophosphoric acid) in the ratio of 60:40. The flow rate was 1 ml/min and effluent was detected at 321nm. The retention time of Febuxostat and Ketorolac were 2.62 min and 3.96 min. respectively. Linearity was observed in the concentration range of 5-30µg/ml and 10-60 µg/ml for Febuxostat and Ketorolac respectively with correlation coefficient 0.999 for both the drugs. Percent recoveries obtained for both the drugs were 99.75-100.06% and 98.63-99.93%, respectively. The method was validated according to the ICH guidelines with respect to specificity, linearity, accuracy, precision and robustness. The method developed can be used for the routine analysis of Febuxostat and Ketorolac from their combined dosage for