The global burden of cancer attributable to risk factors, 2010–19: a systematic analysis for the Global Burden of Disease Study 2019

BACKGROUND: Understanding the magnitude of cancer burden attributable to potentially modifiable risk factors is crucial for development of effective prevention and mitigation strategies. We analysed results from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019 to inform cancer control planning efforts globally. METHODS: The GBD 2019 comparative risk assessment framework was used to estimate cancer burden attributable to behavioural, environmental and occupational, and metabolic risk factors. A total of 82 risk–outcome pairs were included on the basis of the World Cancer Research Fund criteria. Estimated cancer deaths and disability-adjusted life-years (DALYs) in 2019 and change in these measures between 2010 and 2019 are presented. FINDINGS: Globally, in 2019, the risk factors included in this analysis accounted for 4·45 million (95% uncertainty interval 4·01–4·94) deaths and 105 million (95·0–116) DALYs for both sexes combined, representing 44·4% (41·3–48·4) of all cancer deaths and 42·0% (39·1–45·6) of all DALYs. There were 2·88 million (2·60–3·18) risk-attributable cancer deaths in males (50·6% [47·8–54·1] of all male cancer deaths) and 1·58 million (1·36–1·84) risk-attributable cancer deaths in females (36·3% [32·5–41·3] of all female cancer deaths). The leading risk factors at the most detailed level globally for risk-attributable cancer deaths and DALYs in 2019 for both sexes combined were smoking, followed by alcohol use and high BMI. Risk-attributable cancer burden varied by world region and Socio-demographic Index (SDI), with smoking, unsafe sex, and alcohol use being the three leading risk factors for risk-attributable cancer DALYs in low SDI locations in 2019, whereas DALYs in high SDI locations mirrored the top three global risk factor rankings. From 2010 to 2019, global risk-attributable cancer deaths increased by 20·4% (12·6–28·4) and DALYs by 16·8% (8·8–25·0), with the greatest percentage increase in metabolic risks (34·7% [27·9–42·8] and 33·3% [25·8–42·0]). INTERPRETATION: The leading risk factors contributing to global cancer burden in 2019 were behavioural, whereas metabolic risk factors saw the largest increases between 2010 and 2019. Reducing exposure to these modifiable risk factors would decrease cancer mortality and DALY rates worldwide, and policies should be tailored appropriately to local cancer risk factor burden

Reducing the environmental impact of surgery on a global scale: systematic review and co-prioritization with healthcare workers in 132 countries

Background Healthcare cannot achieve net-zero carbon without addressing operating theatres. The aim of this study was to prioritize feasible interventions to reduce the environmental impact of operating theatres. Methods This study adopted a four-phase Delphi consensus co-prioritization methodology. In phase 1, a systematic review of published interventions and global consultation of perioperative healthcare professionals were used to longlist interventions. In phase 2, iterative thematic analysis consolidated comparable interventions into a shortlist. In phase 3, the shortlist was co-prioritized based on patient and clinician views on acceptability, feasibility, and safety. In phase 4, ranked lists of interventions were presented by their relevance to high-income countries and low–middle-income countries. Results In phase 1, 43 interventions were identified, which had low uptake in practice according to 3042 professionals globally. In phase 2, a shortlist of 15 intervention domains was generated. In phase 3, interventions were deemed acceptable for more than 90 per cent of patients except for reducing general anaesthesia (84 per cent) and re-sterilization of ‘single-use’ consumables (86 per cent). In phase 4, the top three shortlisted interventions for high-income countries were: introducing recycling; reducing use of anaesthetic gases; and appropriate clinical waste processing. In phase 4, the top three shortlisted interventions for low–middle-income countries were: introducing reusable surgical devices; reducing use of consumables; and reducing the use of general anaesthesia. Conclusion This is a step toward environmentally sustainable operating environments with actionable interventions applicable to both high– and low–middle–income countries

مكونات الفاصوليا الخضراء ( الدهنيات والفلافرتيد ات )

Chemical study of the lipid fraction resulted in the isolation and identification of a hydrocarbon fraction (n-Czg -0-033); an aliphatic alcohol fraction (C^, Czp, €30) and a sterol fraction (stigmasterol and sitosterol). Analysis of the fatty acids revealed the presence of myristic, palmitic, hexadodecanoic, stearic, oleic and linoleic acids. The flavonoid constituents were identified as kaempferol-3-rutinoside and quercetin-3-rutinoside.أسفرت دراسة الدهنيات عن فصل والتعرف على هيدروكربونات مشبعة ، كحولات اليافتية مشبعة وستيرويدات ( بيتا سيتو ستيرول ستيجما ستيرول ) وأسفر تحليل الاحماض الدهنية عن وجود احماض الميرستيك ، الى الهكساديكانويك ، الستياريك ، الأوليك ، اللينوليك . وقد اسفرت دراسة المواد الفلافونيدية عن التعرف على مركبين. كامبفيرول ، -3-روتينوسيد،كيرستين -3-روتينوسليد

The improvements of three-dimensional seismic interpretation in comparison with the two-dimensional seismic interpretation in Al-Amal oil field, Gulf of Suez, Egypt

Thirteen 2D seismic lines were interpreted with the help of well velocity and time-depth trace conversion to construct the structure-tectonic maps. This is to characterize the different stratigraphic tops of Al-Amal area, as well as to confirm the validity of the proposed structural model. Most of the available seismic data in Al-Amal area were investigated and reviewed to select the best quality set. In order to study the detailed structural elements based on the 3D seismic lines; six depth structure contour maps were constructed on the tops of Zeit, South Gharib, Belayim, Kareem, Nukhul and Matulla formations from top downward. Interpretation was aided by the missing sections detected from the available well tops and dip-meter data as well. These maps indicate that, both of Miocene and Pre-Miocene formations in Al-Amal field were affected by elongated tilted graben blocks trending in the NW–SE directions and bounded by two sets of faults, which are down throwing toward the west and eastern directions