A study on students' idears about the school syllabus

1995年4月に初めての本学のシラバス（講義要覧）が発行され、学生に配布された。本報は約1年後の1996年2月の試験期間中にシラバスに対する学生の意見を問うために行われたアンケート調査の結果をまとめたものである。回答を寄せた学生は435人で、在籍学生の89.0％であった。よく利用したとする学生は18.2％、数回利用したとする学生は67.6％であった。学生の使用目的はテストの準備や履修科目の決定のためであった。以上のことから、現在のシラバスは学生が日常的により活用するためにはさらに教師が改善、工夫する必要があると思われた。The first syllabus of the School was published and distributed to all of the students in April,1995. Ten months later during the term examination, an opportunity arouse to question the sudents about their idears for the syllubus. A survery of all of the students was carried out and 435 students (89.0%) responded to it. They generally utilized it well, especially to decide which subjects they will take, to find out about the textbooks that will be used, and how to prepare for the examination. However it was found not to be sufficient for their daily use. Teachers therefore must make a greater effort in giving information about their lecture

Development of image analysis for detection of defects of BGA by using X-ray images

In the surface mount technology, Ball Grid Array (BGA) has been used in a production of PC boards, because of their excellent characters such as high density of the lead pin pitch, better lead rigidity and self-alignment during re-flow processing. This paper deals with the development of image analysis for the detection of defects at BGA solder joints in PC boards by using X-ray images. In the conventional IC boards, it is possible to detect defects of solder joints by visual inspection, because the lead of IC package is set on its outside. However, we can't detect visually defects at BGA solder joints, because they are hidden under the IC package. In a production line, the inspection of BGA in PC boards depends on the function test of electric circuits in the final process. To improve a cost performance and the reliability of PC boards, an inspection of BGA is required in the surface mount process. Types of defects at BGA solder joints are solder bridge, missing connection, solder voids, open connection and miss-registration of parts. As we can find mostly solder bridge in these defects, we pick up this to detect solder bridge in a production line. The problems of image analysis for the detection of defects at BGA solder joints are the detection accuracy and image processing time according to a line speed of production. To get design data for the development of the inspection system, which can be used easily in the surface mount process, it is important to develop image analysis techniques based on X-ray image data. At the first step of our study, we attempt to detect the characteristic of the solder bridges based on an image analysis. </p

スクリーン／フィルム乳房撮影法における乳房線量測定システム

The average glandular dose to glandular tissue m mammography is generally assumed to be a function of beam quality (HVL), x-ray tube target material, tube voltage, breast thickness, breast composition and, to a lesser extent, x-ray tube voltage waveform. The average glandular dose is generally determined from published tables with knowledge of the above function. Tables for a high frequency x-ray generator are not yet published. In our study, the lookup tables for the average glandular dose were made at 28 kV (high frequency x-ray generator), employing a breast simulating tissue (0-100% adipose tissue, 0-100% glandular tissue) phantom for an Mo target - Mo filter source assembly. We tried to estimate breast composition from x-ray mammograms by digital image processing techniques, also using the simulating tissue phantom. Then the system that automatically calculates the average glandular dose from digitized clinical x-ray mammograms was built. It is considered that this system can contribute to objective evaluation of the average glandular dose.乳房X線撮影法において乳腺組織に対する平均放射線吸収線量，すなわち平均乳腺線量は放射線のリスクの最も有用な測定法であり，現在，乳房に対する線量の評価に用いられている指標である。一般に，平均乳腺線量は線質（HVL），X線管球ターゲット材料，管電圧，圧迫乳房厚さ，乳房構成および（ある程度）X線管電圧波形の関数であるとされている。平均乳腺線量は，上記の関数についての情報を備えた表が公表されており，一般にその表を使って決定されている。近年，インバータ式といわれる高周波X線発生装置が普及してきた。しかし，その装置用の表は，まだ公表されていない。我々の研究では，乳房組織をシュミレートするファントム（0～100％乳腺組織，0～100％脂肪組織）を使用して，28kVでMoターゲット―Moフィルタソースアセンブリーを備えた高周波X線発生装置のために，平均乳腺線量用のルックアップテーブルを作成した。同様に，乳房組織をシュミレートするファントムを使用して，乳房X線写真から，ディジタル・イメージプロセシング技術によって，乳房構成の評価を試みた。そして，ディジタイズされた臨床乳房X線写真から，平均乳腺線量を自動的に計算するシステムを構築した。サンプル数が少ないため断定はできないが，日本女性は，基準構成（50％の脂肪および50％の乳腺組織）と比較すると，脂肪が少ない傾向を分析結果は示唆していた。また，平均乳腺吸収線量の限度は，明確に規定されていないが，American College of Radiology（ACR）は4 mGyなどを推奨している。また日本では，3 mGyが推奨されているが，我々の撮影システムはこれらを十分満足していた。このように本システムは，平均乳腺線量の客観的な評価に寄与するとともに，DR（digital radiography）などに応用すると，すなわちルックアップテーブルをDRのコンピュータに保存しておけば，撮影後すぐに乳房構成および平均乳腺線量を算出できる可能性をもつ

Detection of defects at BGA solder joints by using X-ray imaging

In the surface mount technology, a ball grid array (BGA) has been used in the production of PC boards. This paper deals with the detection of defects at BGA solder joints in PC boards by using X-ray imaging. Types of defects at BGA solder joints are solder bridge, missing connection, solder voids, open connection and misregistration of parts. The problems of image analysis for the detection of defects at BGA solder joints are the detection accuracy and image processing time according to the speed of the production line. To get the design data for the development of the inspection system used in the surface mount process, it is important to develop image analysis techniques based on X-ray image data. At the first step of our study, we attempt to detect the characteristics of the solder bridges based on the image analysis technique. </p

Extended-cycle processによる乳房撮影用増感紙／フィルムシステムの画質改善

Extended-cycle process is the term used for a processor in which the processing time has been prolonged usually to approximate 210 seconds. It has been known that the extended-cycle process of some single-emulsion films as used for mammography may enhance film contrast and increase film speed. So the speed was increased in lower speed and higher resolution system than conventional systems by means of using the extended-cycle process in this paper. We investigated how much the resolution of the system was kept. A single screen-single emulsion combination, Konica M-100/CM-H was employed as a low speed and high resolution system. This film after exposure was processed in the different combinations of developing temperatures, 30, 32 and 34℃, and processing time of 210 seconds. On the other hand, Konica M-200/CM-H was employed as a high speed system. This film was processed in the standard-cycle processing (34℃, 90 seconds). Those systems were compared on contrast, speed, screen-film blur and noise by a characteristic curve, MTF (modulation transfer function) and WS (wiener spectrum). Furthermore, the RMI 165 phantom was used to evaluate visibility of mammographic details of these systems. As a result, in the extended-cycle process at the developing temperatures of 32 or 34°C and processing time of 210 seconds for M-100/CM-H, it was possible to increase the speed as much as the higher speed system, M-200/CM-H. Then the contrast, the MTF and the visibility were also improved as compared to the higher speed system. Furthermore patient dose could be reduced at the developing temperature of 34℃ and processing time of 210 seconds in M-100/CM-H.通常,extended-cycle processは処理時間が約210秒に延ばされた現像機のために使われる用語である｡乳房撮影に使われるような片面乳剤フィルムにおけるextended-cycle processは,フィルムコントラストを増し,感度をあげることが良く知られている｡そこで,本論文ではextended-cycle processにより低感度,高解像度システムの感度を上げ,どの程度解像度が維持されるかを調べた｡片面増感紙／片面フィルムの組合わせであるKonica M-100/CM-Hを低感度,高解像度システムとして用いた｡露光後のフィルムは現像温度30,32, 34度,処理時間210秒の異なる組合わせで現像処理した。一方,高感度システムとしてKonica M-200/CM-Hを用い,このフィルムは標準現像(34℃,90秒)された｡感度,増感紙／フイルムのぼけ,雑音に関して,特性曲線,MTF(modulation transfer function), WS(wiener spectrum)によってこれらのシステムを比較した｡さらにこれらのシステムにおける乳房写真の細部視覚評価のためにRM165ファントムを使用した｡その結果,M-100/CM-Hに対するextended-cycle process現像温度32, 34℃,処理時間210秒のextended-cycle processにおいて,高感度システムM-200/CM-Hと同等の感度を上げることが可能であった｡そのとき,コントラスト,MTF,視覚的検出能も高感度システムより向上した｡さらに,現像温度34℃,処理時間210秒では,被曝線量の低減が可能であった

New Stepwedge for Bootstrap Sensitometry in Medical Radiography

A new stepwedge has been developed for bootstrap sensitometry, which is used for determining the characteristic curve of radiographic screen/film systems. Since each step of the stepwedge is separated by the lead septum, flare generated under one step will not penetrate the region of another step. The metal of the stepwedge can be changed with various materials. Characteristic curves obtained with new stepwedge bootstrap (NSB) and conventional stepwedge bootstrap (CSB) techniques were compared with those obtained for screen/film systems with inverse sqare sensitometry. The inverse square method was used as the reference standard for accuracy. The NSB method provided characteristic curves that agreed well with those obtained using the inverse square method. The slope of the curve in the CSB method was lower than that in the inverse square or NBS method, because of scatter radiation. The shape of the characteristic curve from the NSB method did not vary with the materials of step metals (aluminum and copper). The cumulative error involved when using the bootstrap method is also discussed

現像温度および時間のマンモフイルム特性に与える影響

The influence for developing temperature and processing time within film processing conditions was investigated using four mammographic films, Konica New CM, Fuji UM-MA HC, Kodak Min-R M and Kodak EB/RA (for rapid system). And Fuji UR-2, a double-emulsion film, was used as a control. Those sensitometric strips exposed by a sensitometer were processed in the different combinations of developing temperatures ranging from 28 to 36℃, processing times from 45 to 210 sec. Average gradient, relative speed and base plus fog obtained from the measured film characteristic curves were evaluated for the different developing temperatures and times. Fuji UR-2 was scarcely affected and mammographic films were greatly affected in the different combinations without an increase in base plus fog except EB/RA. In New CM, UM-MA HC and Min-R M, the average gradients and the relative speeds increased as the developing temperature was higher and the developing time was longer, but the increases were limit on the combination of 36℃ and 210 sec in New CM and UM-MA HC. In EB/RA, the average gradients were almost constant and the relative speeds increased slightly like the double-emulsion film. These results suggested that it would be possible to contribute to dose reduction and advancement of contrast in New CM, UM-MA HC and Min-R M by changing these processing parameters.フィルム処理条件において,現像温度と処理時間に対する影響を4種類のマンモグラフィ用フィルムKonica New CM, Fuji UM-MA HC,Kodak Min-R M,迅速処理用Kodak EB/RAについて調べた｡そして,比較基準用として両面乳剤フィルムFuji UR-2を用いた｡感光計で露光したフィルムを現像温度28～36℃,処理時間45～210秒で処理した｡特性曲線から得られたフィルム特性（平均階調度,相対感度,カブリ濃度）を異なる現像温度,現像時間に対して評価した｡UR-2はほとんど影響を受けず,マンモグラフィ用フィルムは,カブリ濃度が上昇することなく,現像条件の影響を大きく受けた。New CM, UM-MA HC,Min-R Mは現像温度の上昇,処理時間の延長に伴い,平均階調度と相対感度は増加した｡しかし,New CM, UM-MA HCの36℃,210秒で増加は限度に達した｡EB/RAの平均階調度は一定で,相対感度は両面乳剤フイルムと同 様にわずかな増加であった｡これらの結果は,New CM, UM-MA HC, Min-R Mにおいて,処理条件を変化させることにより,被曝低減,コントラスト向上に貢献できる可能性を示唆していた

Faculties' ideas to the school syllabus

シラバスは、その内容も含めて、まだ教官にも、学生にもなじみのない言葉である。著者らは、1994年、初めてのシラバス（講義要覧）を刊行した。このシラバスの中では、1人もしくは数人の教官によって、１教科・１学期分の講義の概要が各1ページの中に記載され、その枠組みは、基本的事項以外に、抗議の目標、授業計画、授業計画、教科書、参考書、授業の進め方、評価の方法、教官のメッセージから成るものであった。このシラバス作成に参加した専任教官45人及び非常勤教官107人、計153人に対し、調査表によってシラバス作成に関する意見を求めた結果、117人（77.0％）の教官が解答を寄せた。その結果は次のようなものであった。1.今回の作成計画以前にシラバスについて認識があった者は44.5％であった。しかし、シラバスの今後の発行に関しては94.9％の者が賛成であった。今回の枠組みについてはほとんどの者が肯定的であった。2.学生による授業評価については、約半数（52.7％）が賛成であるが、時期尚早とする者が41.8％いた。The term 'syllabus' and its concept are not familiar to university faculty members and students in Japan. Authors who belonged to School of Health Sciences Okayama University, published the first syllabus in 1994. In this syllabus, an outline of each course for a semester was shown by one or a few faculty members. The framework consisted of the mark of the subject, schedule, textbook, reference book, how to teach, how to grade and message to students, besides basic information. Forty-five full-time faculty members and 107 part-time faculty members were asked about their ideas for the syllabus through a questionnaire survey by mail and 119 faculty members (78.3%) responded to it. Only fifty-three faculty members (44.5%) had known the term 'syllabus' before the time when they started to talk about it or were asked to write it. But after their presenting syllabi, 104 faculty members (87.4%) agreeded to continue publishing and they were affirmative to framework as it was proposed this time. As for evaluation of subject by students, about half of faculties (52.7%) agreeded and 51.8% of them replied that were not mature enough for it yet

TONS504-PHOTODYNAMIC THERAPY INDUCES CYTOTOXIC EFFECTS IN EMT6 CELLS

In the present study, TONS504 (C51H58N8O5I2; molecular weight, 1,116.9), a novel cationic hydrophilic photosensitizer, was synthesized from protoporphyrin IX dimethyl ester through a five‑step process according to a patented method for use in photodynamic therapy (PDT). The subcellular localization of TONS504 and the cytotoxic effects of TONS504‑mediated PDT in the mouse mammary tumor EMT6 cell line were investigated. TONS504 was localized primarily in the lysosomes and partially in the mitochondria. The cytotoxic effects of TONS504‑mediated PDT in the mouse mammary tumor EMT6 cell line were investigated using a WST8 assay and an Oxidative Stress kit. The cell viability values following treatment with 10 µg/ml TONS504 at light energies of 0, 1, 5 and 10 J/cm2 were 92.5, 101.8, 27.7 and 1.8%, respectively. The percentages of reactive oxygen species (ROS)(+) cells following the same treatment were 8.6, 8.5, 29.2 and 70.1%, respectively, whereas the percentages of apoptotic cells were 7.1, 5.6, 24.8 and 48.7%, respectively. The percentages of ROS(+) and apoptotic cells in the group subjected to TONS504‑mediated PDT increased in a manner dependent on the TONS504 concentration and light energy. Further studies are required to evaluate the in vivo pharmacokinetics, tissue distribution and photodynamic effects of TONS504