Nilai-Nilai Tasawuf Ajaran Sunan Drajat

Penelitian ini bertujuan untuk mengungkap kembali nilai-nilai subtansi tasawuf Sunan Drajat. Penelitian ini adalah penelitian empiris yang merujuk pada data dari lapangan dan dianalisa dengan beberapa kitabnya Sunan Drajat seperti Bayan Alim, Puspa Renonce serta beberapa buku pendukung seperti karya dari Raden Danukusomo, Sejatine Manungsa dan buku Sejarah Sunan Drajat dalam Jaringan Masuknya Islam di Nusantara. Data diperoleh dari hasil wawancara, dokumentasi dan analisa yang ada dilapangan. Hasil penelitian ini, berdasarkan temuan yang diperoleh penulis terhadap nilai-nilai tasawuf Sunan Drajat yang ada di Desa Drajat Paciran Lamongan dengan teori interpretasi Kejawen Jawa dan filsafat perennial, yaitu: Pertama, tasawuf ala Sunan Drajat bukan hanya sebatas amaliah-amaliah seperti yang ada tapi mampu menyampaikannya di berbagai kesenian seperti, singo mengkok, pahatan bunga teratai, tembang pangkur, kungcup masjid Sunan Drajat dan banyak yang lainnya. Kedua, Sunan Drajat berhasil mengakulturasikan nilai-nilai tasawuf dalam berbagai tradisi atau khazanah yang ada tanpa adanya gesekan antara satu dengan yang lain. Ketiga, Sunan Drajat mampu menyesuaikan karakter, alam pikiran masyarakat Nusantara dan tradisi yang ada dengan titik pijak Islam yang bercorak sufistik. Keempat, Tasawuf Sunan Drajat adalah bagian dari Kejawen Jawa yang pada dasarnya berasal dari buah pemikiran para Walisanga untuk mengislamkan dipulau Jawa. Kelima, Nilai-Nilai Tasawuf Sunan Drajat selaras dengan filsafat perennial yang bertendensi bahwa kebenaran bersifat abadi dan berdasarkan petunjuk Tuhan. Keenam, Filsafat perennial berpendapat bahwa apa yang dihadapi oleh manusia modern saat ini adalah melupakan Tuhan sehingga tidak punya tujuan yang pasti begitu juga dalam nilai-nilai tasawuf Sunan Drajat yang juga menekankan tujuan hidup ini semata-mata karena Allah SWT

Automated and high accuracy out-of-hospital heart diseases early detection system

Background: ECG measurement and analysis being performed in-hospital normally check patients with obvious symptoms. Asymptomatic patients, for example, those with silent ischemia, paroxysmal atrial fibrillation and Brugada syndrome are very difficult to detect using in-hospital ECG system. To make matter worst, conventional ECG analysis techniques only focuses in time domain that limits the sensitivity, specificity and accuracy of the interpretation due to ECG signals non-stationary nature. Most recent researches have proposed linear joint time-frequency analysis to overcome these limitations, however, their linear methods limit their accuracy. Objective: The main objective is to enable automated and high accuracy out-of-hospital ECG analysis for early detection of heart disease. Materials & Methods: MIT-BIH ECG databases are used to test the performance of the proposed system. The data is pre-processed for amplitude normalization and frequency resampling. The pre-processed output is then fed to the non-linear joint time-frequency algorithm for analysis. The outcome of the analysis is further classified by the machine learning algorithm. Before the classification can be performed, the intelligent classifier is trained using control data that contains 52 normal and 148 patients data. After that, it is used for classifying 40 normal and 88 patients with ischaemia. The entire processes is automated inside a computer. The main disadvantage of the proposed non-linear joint time-frequency technique together with the intelligent classification is that it requires huge amount of computing system resources (big data problem). To solve this issue the system can be connected to the cloud to further enhance the performance and the accuracy of the system. Results: The analysis is performed on 421632 normal and 863282 patients ECG beats. The results obtained show that the system gives high performance of accuracy, sensitivity and specificity with values of 99.03%, 99.59% and 99.57%, respectively. Conclusions: The proposed method operates in joint time-frequency in non-linear fashion. Hence it produces more accurate interpretation compared to the conventional time domain and the more recent linear time-frequency techniques. The high accuracy together with the automated capability of the system can help detect heart problems at the early stages even before the patients pay visit to the hospital

Nilai-Nilai Tasawuf Ajaran Sunan Drajat

Penelitian ini bertujuan untuk mengungkap kembali nilai-nilai subtansi tasawuf Sunan Drajat. Penelitian ini adalah penelitian empiris yang merujuk pada data dari lapangan dan dianalisa dengan beberapa kitabnya Sunan Drajat seperti Bayan Alim, Puspa Renonce serta beberapa buku pendukung seperti karya dari Raden Danukusomo, Sejatine Manungsa dan buku Sejarah Sunan Drajat dalam Jaringan Masuknya Islam di Nusantara. Data diperoleh dari hasil wawancara, dokumentasi dan analisa yang ada dilapangan. Hasil penelitian ini, berdasarkan temuan yang diperoleh penulis terhadap nilai-nilai tasawuf Sunan Drajat yang ada di Desa Drajat Paciran Lamongan dengan teori interpretasi Kejawen Jawa dan filsafat perennial, yaitu: Pertama, tasawuf ala Sunan Drajat bukan hanya sebatas amaliah-amaliah seperti yang ada tapi mampu menyampaikannya di berbagai kesenian seperti, singo mengkok, pahatan bunga teratai, tembang pangkur, kungcup masjid Sunan Drajat dan banyak yang lainnya. Kedua, Sunan Drajat berhasil mengakulturasikan nilai-nilai tasawuf dalam berbagai tradisi atau khazanah yang ada tanpa adanya gesekan antara satu dengan yang lain. Ketiga, Sunan Drajat mampu menyesuaikan karakter, alam pikiran masyarakat Nusantara dan tradisi yang ada dengan titik pijak Islam yang bercorak sufistik. Keempat, Tasawuf Sunan Drajat adalah bagian dari Kejawen Jawa yang pada dasarnya berasal dari buah pemikiran para Walisanga untuk mengislamkan dipulau Jawa. Kelima, Nilai-Nilai Tasawuf Sunan Drajat selaras dengan filsafat perennial yang bertendensi bahwa kebenaran bersifat abadi dan berdasarkan petunjuk Tuhan. Keenam, Filsafat perennial berpendapat bahwa apa yang dihadapi oleh manusia modern saat ini adalah melupakan Tuhan sehingga tidak punya tujuan yang pasti begitu juga dalam nilai-nilai tasawuf Sunan Drajat yang juga menekankan tujuan hidup ini semata-mata karena Allah SWT

Natural convection and entropy generation of MgO/water nanofluids in the enclosure under a magnetic field and radiation effects

The authors of the present paper sought to conduct a numerical study on the convection heat transfer, along with the radiation and entropy generation (EGE) of a nanofluids (NFs) in a two and three-dimensional square enclosure, by using the FVM. The enclosure contained a hightemperature blade in the form of a vertical elliptical quadrant in the lower corner of the enclosure. The right edge of the enclosure was kept at low temperature, while the other edges were insulated. The enclosure was subjected to a magnetic field (MGF) and could be adjusted to different angles. In this research, two laboratory relationships dependent on temperature and volume fraction were used to simulate thermal conductivity and viscosity. The variables of this problem were Ra, Ha, RAP, nanoparticle (NP) volume fraction, blade aspect ratio, enclosure angles, and MGF. Evaluating the effects of these variables on heat transfer rate (HTR), EGE, and Be revealed that increasing the Ra and reducing the Ha could increase the HTR and EGE. On the other hand, adding radiation HTR to the enclosure increased the overall HTR. Moreover, an augmentation of the volume fraction of magnesium oxide NPs led to an increased amount of HTR and EGE. Furthermore, any changes to the MGF and the enclosure angle imposed various effects on the HTR. The results indicated that an augmentation of the size of the blade increased and then decreased the HTR and the generated entropy. Finally, increasing the blade always increased the Be.http://www.mdpi.com/journal/processespm2022Mechanical and Aeronautical Engineerin

Abstract 5575: Obesity and genomic changes in patients with myelodysplastic syndromes

Abstract Obesity is rapidly overtaking smoking as the leading preventable cause of cancer, particularly in cancers of the breast and colon. In a large cohort of individuals participating in the National Institutes of Health-AARP Diet and Health Study, a higher incidence of MDS and an increased mortality was observed in individuals with body mass index (BMI) >30 compared to those with BMI <25 (HR 2.18 (95% CI: 1.51, 3.17; P < 0.001). The biology underlying these findings in MDS patients (pts) is not established. We hypothesized that genomic patterns may distinguish obese from non-obese pts with MDS and that these genomic changes may be associated with disease characteristics. We performed genomic analyses by using next-generation targeted deep sequencing (NGS) and whole exome sequencing (WES) of 62 significantly affected genes that play an important role in MDS pathogenesis. Mutations were considered individually and grouped into several functional pathways. Overweight (BMI 25-29) and obese (BMI >30) were combined in one group (BMI-H). Of 205 pts with MDS treated at our institution between 1/2000 - 1/2013, 146 (71%) were BMI-H. Interestingly, only 2 patients had BMI <18.5 (underweight) and were combined with normal BMI group (BMI-N). BMI-H pts presented with lower white blood count (median 3.6 vs. 4.4, p = .03), but other clinical characteristics were similar. With median follow up of 33.6 months (mo) (range 0.4-128.5), a trend toward inferior survival was observed in BMI-H group compared to BMI-N (32.9 mo vs. 34.8 mo, p = .07). Furthermore, higher rates of progression to acute myeloid leukemia (AML) were seen in the BMI-H as compared to BMI-N pts (23% vs. 19%, p = .02). Overall, 74% of pts had at least one of the 62 screened mutations, the most common being: SF3B1 (17%), TET2 (17%), ASXL1 (14%), STAG2 (12%), DNMT3A (9%), U2AF1/2 (8%), GPR98 (8%), and RUNX1(7%). Mutations in IDH1/2 (5% vs. 0%), DNMT3A (11% vs. 5%), TET2 (18% vs. 14%) occurred more frequently in BMI-H, where SF3B1 (25% vs. 13%), and NRAS (7% vs. 2%) mutations were more common in BMI-N. Within functional groups, mutations in splicing machinery genes were less common in BMI-H compared to BMI-N (32% vs. 41%, p = .05) and mutations in DNA methylation genes were more common in BMI-H (20% vs. 34%, p = .02). Clonal architecture analysis points to the presence of different dominant clones between the two groups. In the dominant MDS clones, mutations in TET2 and DNMT3A were observed more frequently in pts with BMI-H, whereas mutations in SF3B1 were more frequently observed in BMI-N pts. In conclusion, overweight and obese pts with MDS have a trend for inferior survival and higher rate of progression to AML as compared to MDS pts with normal weight. Genomic differences in clonal architecture and distribution of somatic mutations were observed in the BMI-H group. Further exploration including germline mutations and previously described familial obesity genes is needed to expound on the interaction between the biology of obesity and leukemogenesis of MDS. Citation Format: Aziz Nazha, David Seastone, Hideki Makishima, Matt Kalaycio, Hetty E. Carraway, Anjali S. Advani, Ahamd Zarzour, Jennifer Carew, Aaron T. Gerds, Sudipto Mukherjee, Jaroslaw P. Maciejewski, Mikkael A. Sekeres. Obesity and genomic changes in patients with myelodysplastic syndromes. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr 5575. doi:10.1158/1538-7445.AM2015-557