44 research outputs found
catena-Poly[[bis(pyrazine-2-carboxamide)mercury(II)]-di-μ-chlorido]
In the polymeric title compound, [HgCl2(C5H5N3O)2]n, the HgII atom (site symmetry ) adopts a distorted trans-HgN2Cl4 octahedral coordination geometry. In the crystal, adjacent mercury ions are bridged by pairs of chloride ions, generating infinite [100] chains, and N—H⋯O and N—H⋯(N,N) hydrogen bonds help to consolidate the packing
Dichloridobis(pyrazine-2-carboxamide-κN 4)zinc(II)
In the crystal of the title compound, [ZnCl2(C5H5N3O)2], the molecule has m symmetry, with the ZnII cation and Cl− anions located on the mirror plane. The ZnII cation is coordinated by two Cl− anions and two pyrazine-2-carboxamide ligands in a distorted ZnCl2N2 tetrahedral geometry. The two pyrazine rings are nearly perpendicular to each other [dihedral angle = 86.61 (10)°]. Intermolecular N—H⋯O and N—H⋯N hydrogen bonds and weak C—H⋯O interactions stabilize the crystal packing
Dibromidobis(pyrazine-2-carboxamide-κN 4)zinc
The title complex, [ZnBr2(C5H5N3O)2], shows crystallographic mirror symmetry with the Zn atom and the two bromine ligands located on the mirror plane. The Zn atom is four-coordinated in a distorted tetrahedral fashion by two N atoms from two pyrazine-2-carboxamide ligands and two Br atoms. Only one of the amino H atoms is involved in an N—H⋯O hydrogen bond. The crystal packing is further stabilized by weak N—H⋯N and C—H⋯O interactions
ERCPMP: An Endoscopic Image and Video Dataset for Colorectal Polyps Morphology and Pathology
In the recent years, artificial intelligence (AI) and its leading subtypes,
machine learning (ML) and deep learning (DL) and their applications are
spreading very fast in various aspects such as medicine. Today the most
important challenge of developing accurate algorithms for medical prediction,
detection, diagnosis, treatment and prognosis is data. ERCPMP is an Endoscopic
Image and Video Dataset for Recognition of Colorectal Polyps Morphology and
Pathology. This dataset contains demographic, morphological and pathological
data, endoscopic images and videos of 191 patients with colorectal polyps.
Morphological data is included based on the latest international
gastroenterology classification references such as Paris, Pit and JNET
classification. Pathological data includes the diagnosis of the polyps
including Tubular, Villous, Tubulovillous, Hyperplastic, Serrated, Inflammatory
and Adenocarcinoma with Dysplasia Grade & Differentiation. The current version
of this dataset is published and available on Elsevier Mendeley Dataverse and
since it is under development, the latest version is accessible via:
https://databiox.com
catena-Poly[[[aqua(pyrazine-2-carboxamide-κ2 N 1,O)zinc]-μ-pyrazine-2-carboxamide-κ3 N 1,O:N 4] dinitrate]
In the crystal of the title compound, {[Zn(C5H5N3O)2(H2O)](NO3)2}n, the ZnII cation is N,O-chelated by two pyrazine-2-carboxamide (PCA) ligands and is further coordinated by one water molecule and by one pyrazine-N atom from an adjacent PCA ligand in a distorted ZnN3O3 octahedral geometry. One of the two independent PCA ligands bridges two ZnII cations, forming a zigzag polymeric chain running along the c axis. In the crystal, the NO3
− anions link to the chain via O—H⋯O and N—H⋯O hydrogen bonding. Weak intermolecular C—H⋯O interactions also occur
catena-Poly[[bis(pyrazine-2-carboxamide-κN 4)mercury(II)]-di-μ-bromido]
In the crystal structure of the title compound, [HgBr2(C5H5N3O)2]n, the HgII cation is located on an inversion center and is coordinated by two N atoms from the pyrazine rings and four bridging Br− anions in a distorted octahedral geometry. The Br− anions bridge the HgII cations with significantly different Hg—Br bond distances of 2.4775 (8) and 3.1122 (8) Å, forming polymeric chains running along the a axis. Intermolecular N—H⋯O and N—H⋯N hydrogen bonds are effective in the stabilization of the crystal structure
Diaquabis(pyrazine-2-carboxamide-κ2 N 1,O)cobalt(II) dinitrate
The asymmetric unit of the title complex, [Co(C5H5N3O)2(H2O)2](NO3)2, contains one half of a CoII cationic unit and a nitrate anion. The entire [Co(C5H5N3O)2(H2O)2]2+ cationic unit is completed by the application of inversion symmetry at the CoII site, generating a six-coordinate distorted octahedral environment for the metal ion. The chelating pyrazine-2-carboxamide molecules are bound to cobalt via N and O atoms, forming a square plane, while the remaining two trans positions in the octahedron are occupied by two coordinated water molecules
MicroRNAs as Biomarkers for Early Diagnosis, Prognosis, and Therapeutic Targeting of Ovarian Cancer
Ovarian cancer is the major cause of gynecologic cancer-related mortality. Regardless of outstanding advances, which have been made for improving the prognosis, diagnosis, and treatment of ovarian cancer, the majority of the patients will die of the disease. Late-stage diagnosis and the occurrence of recurrent cancer after treatment are the most important causes of the high mortality rate observed in ovarian cancer patients. Unraveling the molecular mechanisms involved in the pathogenesis of ovarian cancer may help find new biomarkers and therapeutic targets for ovarian cancer. MicroRNAs (miRNAs) are small noncoding RNAs that regulate gene expression, mostly at the posttranscriptional stage, through binding to mRNA targets and inducing translational repression or degradation of target via the RNA-induced silencing complex. Over the last two decades, the role of miRNAs in the pathogenesis of various human cancers, including ovarian cancer, has been documented in multiple studies. Consequently, these small RNAs could be considered as reliable markers for prognosis and early diagnosis. Furthermore, given the function of miRNAs in various cellular pathways, including cell survival and differentiation, targeting miRNAs could be an interesting approach for the treatment of human cancers. Here, we review our current understanding of the most updated role of the important dysregulation of miRNAs and their roles in the progression and metastasis of ovarian cancer. Furthermore, we meticulously discuss the significance of miRNAs as prognostic and diagnostic markers. Lastly, we mention the opportunities and the efforts made for targeting ovarian cancer through inhibition and/or stimulation of the miRNAs