ANALISIS KELAYAKAN USAHA PENGOLAHAN IKAN SALAI DI KELURAHAN AIR DINGIN KECAMATAN BUKIT RAYA KOTA PEKANBARU PROVINSI RIAU (Studi Kasus Pada Usaha Ikan Salai Sedap Bakat)

This study aims to analyze the characteristics of entrepreneurs and smoked fish business profile; availability, acquisition, and use of raw materials and supporting materials for smoked fish processing business; non-financial business feasibility and financial feasibility of smoked fish processing business; and the sensitivity of the smoked fish processing business. The method used in this research was a case study in the processing business of "Spiced Fish Bakat" in Air Dingin Village, Bukit Raya District, Pekanbaru City, Riau Province. This research was carried out for six months starting from January to June 2022. The respondents in this study were entrepreneurs and four workers. Data analysis was performed using quantitative and qualitative descriptive analysis (market and marketing aspects, technical aspects, environmental aspects, legal aspects, and management aspects, and financial aspects using four investment criteria (NPV, Net B/C, IRR, and Payback Period) and sensitivity analysis with the Switching Value approach. The results showed that the characteristics of entrepreneurs belong to the productive age with 46 years of age, 16 years of education (graduate) with 12 years of business experience, and 4 family members. Salai Sedap Bakat fish processing business is classified as a small-scale and household business and still uses traditional technology in the production process. Non-financial feasibility from market and marketing aspects, technical aspects, legal aspects, and management aspects of the salai fish business was feasible. The environmental aspect was not yet feasible because there is no provision for waste treatment from the by-products of smoked fish processing. Meanwhile, financially the Salai Sedap Bakat fish processing business is feasible to be continued and developed because it is profitable based on 4 investment criteria with an NPV of IDR 50,086,397 > 0, Net B/C with a value of 1.43 > 1, an IRR value of 21% > i ( 6.69%) and Payback Period for 4 years 1 month 5 days < business life (10 years). Based on sensitivity analysis using the switching value approach, the profit of the Salai Sedap Bakat Fish Business was more sensitive to the decline in the price of catfish production with a decrease in the NPV value of 90.65% and a decrease in the production of smoked catfish with a percentage of 90.28% compared with an increase in operational costs with a percentage of 82.36% of the base value

ANALISIS KELAYAKAN USAHA AGROWISATA KAMPOENG RABBIT’S DI KELURAHAN MENTANGOR KECAMATAN TENAYAN RAYA KOTA PEKANBARU PROVINSI RIAU

Agrotourism is a tourist activity that involves the use of agricultural land or related facilities that become an attraction for tourists. Agriculture in the broadest sense includes people's agriculture, plantations, livestock, fisheries, and forestry. This study aims to analyze: The financial viability of the agrotourism business kampoeng rabbit's. The research method is a survey method, on the agrotourism business kampoeng rabbit's in the Village of Mentangor District Tenayan Raya Kota Pekanbaru. The study was conducted for 6 months starting from August 2020 to January 2021. The respondents in this study were entrepreneurs and 8 workers. Furthermore, this study was analyzed descriptively quantitatively, business analysis, investment criteria (Net Present Value, Internal Rate Of Return, Net B /C and Payback Period). The types of data used are secondary data and primary data. The results of this study showed that the financial feasibility analysis of the ecotourism business kampoeng rabbit's worthy because it has met 4 investment criteria with an NPV value of 637,900,658 > 0, Net B / C 1.17 > 1, IRR 29% > 12% payback rate for 2 years 11 months 2 days < business life (10 years)

Collagen-based scaffolds with infused anti-VEGF release system as potential cornea substitute for high-risk keratoplasty: A preliminary in vitro evaluation

Currently the only widely accepted corneal blindness treatment is human donor cornea transplantation. However, increasing shortage of donor corneas as well as high risk of rejection in some corneal diseases remain two major problems, which limit the success of corneal transplantation. Corneal neovascularization is considered as one of the main risk factors of graft failure. Different cell-free biosynthetic scaffolds fabricated from collagens or collagen-like peptides are being tested as donor cornea substitutes (DCS). Here, we report for the first-time composite biosynthetic DCS with integrated sustained release system of anti-VEGF drug, bevacizumab and their preliminary in vitro validation. We have tethered gold nanoparticles with bevacizumab and integrated into a collagen-based cell-free hydrogel scaffold. Developed grafts preserved good optical properties and were confirmed not toxic to human corneal epithelial cells. Bevacizumab has been shown to constantly releasing from the DCS up to 3 weeks and preserved its anti-angiogenic properties. These results provide background for further use of infused composite biosynthetic DCS with integrated nanosystem of bevacizumab sustained release in corneal disease accompanied by neovascularisation where conventional corneal transplantation might fail

Deep Learning

Deep Learning was developed as a Machine learning approach to influence advanced input-output mappings. It had been for learning concerning multiple levels of illustration and abstraction to create sense of the information such as images, text and sound. Deep learning excels at distinguish patterns in unstructured information, that most of the people grasp as media like images, sound, video and text

Statistical Model Derivation and Extension of Hardy – Weinberg Equilibrium

The Hardy-Weinberg equilibrium law states that when a population is in equilibrium, the genotypic frequencies will be in the proportion p2 : 2pq: q2 . In a large random mating hypothetical population where the frequencies of alleles A1 and A2 are respectively is p and q, each genotype passes on both alleles with equal frequency over generations in the absence of evolutionary forces (Mutation, migration, and selection). In this paper, the Hardy-Weinberg equilibrium law is derived and extended to the third generation, and the corresponding proportion of frequencies is derived with all mating patterns. The mating frequency matrix is also given. Further, the law is generalized for multiple alleles and generations using binomial expansio

Statistical Model Derivation and Extension of Hardy-Weinberg Equilibrium

The Hardy-Weinberg equilibrium law states that when a population is in equilibrium, the genotypic frequencies will be in the proportion p2 : 2pq: q2 . In a large random mating hypothetical population where the frequencies of alleles A1 and A2 are respectively is p and q, each genotype passes on both alleles with equal frequency over generations in the absence of evolutionary forces (Mutation, migration, and selection). In this paper, the Hardy-Weinberg equilibrium law is derived and extended to the third generation, and the corresponding proportion of frequencies is derived with all mating patterns. The mating frequency matrix is also given. Further, the law is generalized for multiple alleles and generations using binomial expansion

Sclerotium rolfsii Lectin Induces Stronger Inhibition of Proliferation in Human Breast Cancer Cells than Normal Human Mammary Epithelial Cells by Induction of Cell Apoptosis

Sclerotium rolfsii lectin (SRL) isolated from the phytopathogenic fungus Sclerotium rolfsii has exquisite binding specificity towards O-linked, Thomsen-Freidenreich (Galβ1-3GalNAcα1-Ser/Thr, TF) associated glycans. This study investigated the influence of SRL on proliferation of human breast cancer cells (MCF-7 and ZR-75), non-tumorigenic breast epithelial cells (MCF-10A) and normal mammary epithelial cells (HMECs). SRL caused marked, dose-dependent, inhibition of proliferation of MCF-7 and ZR-75 cells but only weak inhibition of proliferation of non-tumorigenic MCF-10A and HMEC cells. The inhibitory effect of SRL on cancer cell proliferation was shown to be a consequence of SRL cell surface binding and subsequent induction of cellular apoptosis, an effect that was largely prevented by the presence of inhibitors against caspases -3, -8, or -9. Lectin histochemistry using biotin-labelled SRL showed little binding of SRL to normal human breast tissue but intense binding to cancerous tissues. In conclusion, SRL inhibits the growth of human breast cancer cells via induction of cell apoptosis but has substantially less effect on normal epithelial cells. As a lectin that binds specifically to a cancer-associated glycan, has potential to be developed as an anti-cancer agent

EDUKASI PENCEGAHAN PENULARAN DAN PENGOBATAN SKABIES PADA SANTRI DAN SANTRIWATI DI PONDOK PESANTREN X KABUPATEN LOMBOK TIMUR

Skabies merupakan infeksi kulit yang disebabkan oleh tungau Sarcoptes scabiei varietas hominis. Prevalensi skabies biasanya meningkat 3,6 kali lebih tinggi pada tempat dengan jumlah penghuni padat seperti asrama, panti asuhan, pondok pesantren, dan penjara. Belum pernah ada penyuluhan dan penelitian mengenai skabies di Pondok Pesantren Nurul Ikhlas NW Desa Sajang, Kecamatan Sembalun. Berdasarkan informasi dari Kepala Sekolah dan Pemilik Pondok angka kejadian skabies cukup tinggi dan hampir menjangkit seluruh santri. Program kerja Kuliah Kerja Nyata (KKN) dilakukan dalam bentuk penyuluhan edukasi kesehatan yang bertujuan untuk mengetahui tingkat pengetahuan dan memberikan edukasi kepada santri dan santriwati mengenai pencegahan penularan dan pengobatan skabies. Kegiatan penyuluhan dilaksanakan pada tanggal 19 Januari 2023. Penyuluhan dilakukan dengan metode ceramah dan diskusi yang diikuti oleh 61 peserta dengan rangkaian kegiatan meliputi pre-test, pemutaran video edukasi, gambaran kasus skabies, dan penyampaian materi mengenai skabies. Evaluasi dilakukan dengan menggunakan pre-test dengan instrumen penelitian bertujuan untuk mengetahui tingkat pengetahuan peserta penyuluhan. Hasil penelitian diperoleh tingkat pengetahuan santri termasuk kategori cukup baik sebanyak 21 orang (34,43%), kurang baik sebanyak 30 orang (49,18%), dan baik sebanyak 10 orang (16,39%). Sehingga dapat disimpulkan bahwa tingkat pengetahuan mayoritas santri termasuk dalam katagori kurang baik 49,18%.  Kata kunci: Skabies, Sajang, Pencegahan, Pengobatan, Pondok Pesantre

Convalescent plasma in patients admitted to hospital with COVID-19 (RECOVERY): a randomised controlled, open-label, platform trial

Background: Many patients with COVID-19 have been treated with plasma containing anti-SARS-CoV-2 antibodies. We aimed to evaluate the safety and efficacy of convalescent plasma therapy in patients admitted to hospital with COVID-19. Methods: This randomised, controlled, open-label, platform trial (Randomised Evaluation of COVID-19 Therapy [RECOVERY]) is assessing several possible treatments in patients hospitalised with COVID-19 in the UK. The trial is underway at 177 NHS hospitals from across the UK. Eligible and consenting patients were randomly assigned (1:1) to receive either usual care alone (usual care group) or usual care plus high-titre convalescent plasma (convalescent plasma group). The primary outcome was 28-day mortality, analysed on an intention-to-treat basis. The trial is registered with ISRCTN, 50189673, and ClinicalTrials.gov, NCT04381936. Findings: Between May 28, 2020, and Jan 15, 2021, 11558 (71%) of 16287 patients enrolled in RECOVERY were eligible to receive convalescent plasma and were assigned to either the convalescent plasma group or the usual care group. There was no significant difference in 28-day mortality between the two groups: 1399 (24%) of 5795 patients in the convalescent plasma group and 1408 (24%) of 5763 patients in the usual care group died within 28 days (rate ratio 1·00, 95% CI 0·93–1·07; p=0·95). The 28-day mortality rate ratio was similar in all prespecified subgroups of patients, including in those patients without detectable SARS-CoV-2 antibodies at randomisation. Allocation to convalescent plasma had no significant effect on the proportion of patients discharged from hospital within 28 days (3832 [66%] patients in the convalescent plasma group vs 3822 [66%] patients in the usual care group; rate ratio 0·99, 95% CI 0·94–1·03; p=0·57). Among those not on invasive mechanical ventilation at randomisation, there was no significant difference in the proportion of patients meeting the composite endpoint of progression to invasive mechanical ventilation or death (1568 [29%] of 5493 patients in the convalescent plasma group vs 1568 [29%] of 5448 patients in the usual care group; rate ratio 0·99, 95% CI 0·93–1·05; p=0·79). Interpretation: In patients hospitalised with COVID-19, high-titre convalescent plasma did not improve survival or other prespecified clinical outcomes. Funding: UK Research and Innovation (Medical Research Council) and National Institute of Health Research