46 research outputs found
Backbending in Dy isotopes within the Projected Shell Model
A systematic study of the yrast band in 154-164 Dy isotopes using the
Projected Shell Model is presented. It is shown that, in the context of the
present model, enlarging the mean field deformation by about 20 % allows a very
good description of the spectrum of yrast band in these isotopes. The
dependence of the B(E2) values on angular momentum is also better described
when larger deformations are used. The observed oscillation of g-factors at low
spin states remains an open question for this model.Comment: 17 pages, 7 figures, submitted to Phys. Rev.
DNA Damage Response/Signaling and Genome (In)Stability as the New Reliable Biological Parameters Defining Clinical Feature of CLL
Competition between molecular and anionic diffusion of oxygen in a catalytic membrane reactor for oxidation reaction
Monte Carlo simulation of complex germanium detector systems and Compton suppression spectrometers
Realisation d'un multicompteur gamma et mesures de multiplicite gamma
SIGLEAvailable from CEN Saclay, Service de Documentation, 91191 Gif-sur-Yvette Cedex (France) / INIST-CNRS - Institut de l'Information Scientifique et TechniqueFRFranc
A Novel Parameter for the Diagnosis of Iron Deficiency: The Transferrin/Albumin Ratio.
Abstract
Iron deficiency (ID) is generally easily diagnosed by a serum ferritin concentration less than 12 μg/L. However, in patients with concomitant pathologies, sensitivity of ferritin for diagnosing ID is low, since inflammation or liver disease can lead to normal or increased ferritin values, even when iron deficiency. In this study, we propose a new marker for diagnosing ID in patients with chronic disease: the Transferrin/Albumin ratio (Tf/A ratio). Indeed, the synthesis and the elimination of albumin and transferrin are regulated by similar processes, excepted in ID. In the latter, the synthesis of transferrin is stimulated, whereas that of albumin is not. Therefore, the Tranferrin/Albumin ratio increases in case of ID, even when transferrin values are within the normal range. To determine the accuracy of this novel parameter, we studied 75 patients with chronic disease who were submitted to bone marrow aspirates and iron staining. Iron stores depletion was defined by less than 10% sideroblasts, without extra-cellular iron nor siderocytes. Blood samples were routinely undertaken at the time of the medullar sampling for determination of hematological and biochemical parameters. Iron status including ferritin, Tranferrin Saturation (TfSat), soluble Transferrin Receptor (sTfR), sTfR/log ferritin and Tf/A ratio, was determined. The diagnostic accuracy of the Tf/A ratio was compared to previously described parameters of iron status that we cited above. Receiver Operating Characteristics (ROC) curves were built to determine the best cut-off values for the prediction of iron deficiency. According to the Perls’ reaction, 25 of the 75 patients (33%) had depleted iron stores and 50 had normal or increased iron stores. Sixteen iron-depleted patients (67%) had anemia. Mann and Whitney U test showed that parameters significantly associated with ID were: Tf, Tf/A ratio, ferritin, TfSat, sTfR, sTfR/log ferritin, mean corpuscular volume, mean corpuscular hemoglobin, red blood cell and reticulocyte counts. In a multivariate analysis, the only significant, independent predictor of iron depletion was the Tf/A ratio (r = 0.637, p < 0.005). The sensitivity/specificity of Tf/A ratio at a cut-off point of 6.4% as given by ROC curve were 80%/88%. In conclusion, the Tf/A ratio is useful in the detection of iron depletion in patients with chronic disease and could dispense with bone marrow aspirate and Perls’ reaction in more than 80% of cases.</jats:p
