7 research outputs found

    Investigation of the properties changes observed for plastic samples made by fused deposition modelling under radiation exposure

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    This work shows investigation of the transmission dynamics of polymer samples made of PLA plastic (polylactide) by fused deposition modelling for electron beam. Besides, results of tests for mechanical destruction (compression) of plastic samples with radiation exposure and without are shown. Article demonstrates that properties of plastic samples are stable up to 1.5 kGy, that proves the suitability of this material for sample production intended for depth dose distributions of electron beams

    Feasibility Study of a Maglev Planar Motor with Large Range Rotation

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    Feasibility Study of a Maglev Planar Motor with Large Range Rotation

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    Lactobacillus and Bifidobacterium Ameliorate Memory and Learning Deficits and oxidative stress in Aβ (1-42) Injected Rats

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    Gastrointestinal microbiota and its organisms are related to the brain and affect brain functioning including memory and learning. In this study we hence investigated the effects of probiotics on memory and oxidative stress biomarkers in an experimental model of Alzheimer’s disease. Sixty rats were randomly divided into 5 groups: Controls (C), control-probiotics (CP) that received probiotics for 8 weeks, sham operation (S) that had intra hippocampal PBS injection, Alzheimer (Aβ) that had the Aβ 1-42 intra-hippocampal injection and the Alzheimer-probiotics (AP) group, which in addition to being injected Aβ 1-42, received 2g (1010CFU) probiotics (L.acidophilus, L.fermentum, B.lactis, B.longum) for 8 weeks. Memory and learning were measured using the Morris water maze and oxidative stress biomarkers in the hippocampus, using ELISA kits. Morris water maze results indicated that using probiotics, in the Alzheimer-probiotics group, significantly improved spatial memory including scape latency, traveled distance and time spent in target quadrant. There was also improvement in oxidative stress biomarkers such as increased malondialdehyde levels and superoxide dismutase activity following the β-amyloid injection. Overall, it seems that probiotics play an effective role in improving memory deficit and the pathological mechanisms of Alzheimer’s disease by modifying microbiota.The accepted manuscript in pdf format is listed with the files at the bottom of this page. The presentation of the authors' names and (or) special characters in the title of the manuscript may differ slightly between what is listed on this page and what is listed in the pdf file of the accepted manuscript; that in the pdf file of the accepted manuscript is what was submitted by the author

    Low Dose Morphine Enhances Morphine Antinociception Effectsin the Animals Pretreated with Selective and Non-Selective Phosphodiestrase Inhibitors: Effects of phosphodiesterase inhibitors on morphine antinociception

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    In this study, we investigated the interactive effects of intraperitoneal (i.p.)injections of three different phosphodiesterase inhibitors (PDEIs) on morphine-induced analgesia in mice using tail-flick method. Subcutaneous administration of morphine (1, 3 and 6 mg/kg) caused significant antinociceptive effects in a dose dependent manner. Administration of pentoxifylline (12.5, 25, 50 and 100 mg/kg,i.p.), milrinone (3 and 4.5 mg/kg, i.p.) and theophylline (25, 50 and 100 mg/kg, i.p.)as selective and non-seletive phosphodiesterase in hibitors in duced analgesia inmice. We also examined the antinociceptive effects of these three PDEIs incombination with non-effective dose of morphine (1 mg/kg). These combinations increased analgesia effects compared to the either morphine or respective phospho-diestrase inhibitor groups significantly. Our findings strongly suggest that PDEIs can induce analgesia and potentiate morphine antinociception effect via possible interactions on the same molecular or biochemical pathways
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