Biological welfare and nutritional inequality in rural mediterranean Spain: the irrigated area of Valencia, 1859-1939

This article analyses the biological welfare and inequality of the male population of the irrigated area of Valencia between 1859 and 1939. It studies the effects that the agrarian development process had on physical welfare and the relationship between height and access to land ownership. Height data for conscripts in five municipalities constitute the source for the study. The results reveal that there was a growing trend in the evolution of heights in the irrigated area of Valencia at the beginning of agrarian capitalism. Nutritional inequalities can be observed between farmers and farm workers: land owners were taller than landless labourers. However, this biological inequality diminished over the period under study

Differentiation status of primary chronic myeloid leukemia cells affects sensitivity to BCR-ABL1 inhibitors

Tyrosine kinase inhibitors (TKI) are the mainstay treatment of BCR-ABL1-positive leukemia and virtually all patients with chronic myeloid leukemia in chronic phase (CP CML) respond to TKI therapy. However, there is limited information on the cellular mechanisms of response and particularly on the effect of cell differentiation state to TKI sensitivity in vivo and ex vivo/in vitro. We used multiple, independent high-throughput drug sensitivity and resistance testing platforms that collectively evaluated 295 oncology compounds to characterize ex vivo drug response profiles of primary cells freshly collected from newly-diagnosed patients with BCR-ABL1positive leukemia (n = 40) and healthy controls (n = 12). In contrast to the highly TKI-sensitive cells from blast phase CML and Philadelphia chromosome-positive acute lymphoblastic leukemia, primary CP CML cells were insensitive to TKI therapy ex vivo. Despite maintaining potent BCR-ABL1 inhibitory activity, ex vivo viability of cells was unaffected by TKIs. These findings were validated in two independent patient cohorts and analysis platforms. All CP CML patients under study responded to TKI therapy in vivo. When CP CML cells were sorted based on CD34 expression, the CD34-positive progenitor cells showed good sensitivity to TKIs, whereas the more mature CD34-negative cells were markedly less sensitive. Thus in CP CML, TKIs predominantly target the progenitor cell population while the differentiated leukemic cells (mostly cells from granulocytic series) are insensitive to BCR-ABL1 inhibition. These findings have implications for drug discovery in CP CML and indicate a fundamental biological difference between CP CML and advanced forms of BCR-ABL1-positive leukemia.Peer reviewe

On the causes of economic growth in Europe: why did agricultural labour productivity not converge between 1950 and 2005?

The objective of this study is to make a further contribution to the debate on the causes of economic growth in the European Continent. It explains why agricultural labour productivity differences did not converge between 1950 and 2005 in Europe. We propose an econometric model, one combining both proximate and fundamental causes of economic growth. The results show that the continuous exit of labour power from the sector, coupled with the increased use of productive factors originating in other sectors of the economy, caused the efficiency of agricultural workers to rise. However, we offer a complete explanation of the role played by institutions and geographical factors. Thus, we detect a direct and inverse relation between membership of the EU and the Communist bloc and the productivity of agricultural labour. In addition, strong support for agriculture affected productivity negatively

A leader in an emerging new international market: the determinants of French wine exports, 1848–1938

The objective of this article is to provide an in-depth study of France''s performance in the new international wine market that began to take shape from the middle of the nineteenth century. We analyse the main determinants of its success in exporting ordinary and high-quality wine using a gravity model for both types of wine. The article shows how France lost foreign markets in the ordinary wine sector, due to difficulties in maintaining its exports, which resulted from the decrease in production caused by the phylloxera plague and increasing competition from growing numbers of producers who were more efficient at producing these types of wines. However, in the high-quality wine market, French exporters enjoyed considerable success, increasing their exports thanks to their efforts to offer a product that was highly valued abroad and the use of modern marketing and sales techniques. The exports benefited from the fall in transport costs and French colonial expansion. However, exports of both products were severely affected by a series of major events, including the First World War, the Russian Revolution, Prohibition in the US, and the Great Depression. This case study of the wine market shows that the collapse of the first globalization was not the same for all products