Amyloid and tau pathology associations with personality traits, neuropsychiatric symptoms, and cognitive lifestyle in the preclinical phases of sporadic and autosomal dominant Alzheimer’s disease

Background Major prevention trials for Alzheimer’s disease (AD) are now focusing on multidomain lifestyle interventions. However, the exact combination of behavioral factors related to AD pathology remains unclear. In 2 cohorts of cognitively unimpaired individuals at risk of AD, we examined which combinations of personality traits, neuropsychiatric symptoms, and cognitive lifestyle (years of education or lifetime cognitive activity) related to the pathological hallmarks of AD, amyloid-β, and tau deposits. Methods A total of 115 older adults with a parental or multiple-sibling family history of sporadic AD (PREVENT-AD [PRe-symptomatic EValuation of Experimental or Novel Treatments for AD] cohort) underwent amyloid and tau positron emission tomography and answered several questionnaires related to behavioral attributes. Separately, we studied 117 mutation carriers from the DIAN (Dominant Inherited Alzheimer Network) study group cohort with amyloid positron emission tomography and behavioral data. Using partial least squares analysis, we identified latent variables relating amyloid or tau pathology with combinations of personality traits, neuropsychiatric symptoms, and cognitive lifestyle. Results In PREVENT-AD, lower neuroticism, neuropsychiatric burden, and higher education were associated with less amyloid deposition (p = .014). Lower neuroticism and neuropsychiatric features, along with higher measures of openness and extraversion, were related to less tau deposition (p = .006). In DIAN, lower neuropsychiatric burden and higher education were also associated with less amyloid (p = .005). The combination of these factors accounted for up to 14% of AD pathology. Conclusions In the preclinical phase of both sporadic and autosomal dominant AD, multiple behavioral features were associated with AD pathology. These results may suggest potential pathways by which multidomain interventions might help delay AD onset or progression

Strategy for the management of diabetic macular edema: the European Vitreo-Retinal Society macular edema study

Objective. To compare the efficacy of different therapies in the treatment of diabetic macular edema (DME). Design. Nonrandomized, multicenter clinical study. Participants. 86 retina specialists from 29 countries provided clinical information on 2,603 patients with macular edema including 870 patients with DME. Methods. Reported data included the type and number of treatment(s) performed, the pre-and posttreatment visual acuities, and other clinical findings.The results were analyzed by the French INSEE (National Institute of Statistics and Economic Studies). Main Outcome Measures. Mean change of visual acuity and mean number of treatments performed. Results.The change in visual acuity over time in response to each treatment was plotted in second order polynomial regression trend lines. Intravitreal triamcinolone monotherapy resulted in some improvement in vision. Treatmentwith threshold or subthreshold grid laser also resulted in minimal vision gain. Anti-VEGF therapy resulted in more significant visual improvement. Treatment with pars plana vitrectomy and internal limiting membrane (ILM) peeling alone resulted in an improvement in vision greater than that observed with anti-VEGF injection alone. In our DME study, treatment with vitrectomy and ILM peeling alone resulted in the better visual improvement compared to other therapies

of Dansyl Fluorophore Functionalized PEDOT

Fluorescent conducting polymers are gaining increasing popularity in actual applications such as electrochromic device, cell detection and fluorescence sensor. This paper describes the synthesis of new both fluorescent and electrochromic polymer. A new bifunctional material 2,3-dihydrothieno[3,4-b][1,4]dioxin-2-yl)methyl 5-(dimethylamino)naphthalene-1-sulfonate (ED) has been synthesized, characterized and electropolimerized. The polymer film which obtained as a highly stable conducting polymer on ITO glass was characterized by cyclic voltammetry (CV), colorimetry, UV-Vis spectroscopy, fluorescence spectroscopy, fluorescence microscopy and scanning electron microscopy (SEM). The PED film demonstrated light blue, gray and purplish blue colors as well as turquoise blue fluorescence color. Both CV and spectroelectrochemical studies proved that the PED film has exhibited high stable electro activity (98%). Further kinetic studies presented that the PED revealed high optic contrast (36%) and relatively low electrochromic response time (2.0 s). The results prevailed that the PED film is promising candidates for fluorescent detection and device applications. (c) 2017 The Electrochemical Society. All rights reserved

Unique and efficient modulation of polycarbazole thin film surface morphology by electrochemical, photochemical and self-assembly techniques

Surface morphology significantly impacts the performance of conducting polymers by influencing charge transport, electromechanical properties, and diffusion dynamics. Understanding and controlling surface morphology is crucial for optimizing the performance of conducting polymers in various applications. In this work, we synthesized for the first time the Azo-SH molecule containing azobenzene, thiol and carbazole groups, thus enabling it photoactivity, electroactivity and self-assembly properties. By integrating the photosensitive azobenzene and the thiol-terminated functional molecule into the electroactive carbazole group, it has been obtained unique surface morphologies that modulating effectively and efficiently via electrochemical, photochemical and self-assembly. The electroactive and photoactive polymer films obtained by electropolymerization were characterized by AFM, e-QCM, electrochemical impedance and XPS techniques. This study has demonstrated as a proof of concept that the surface properties of thin films formed with all-in-one type molecules can be modified by electrochemical, photochemical and self-assembly techniques. Surface morphology modulation of thin films by including wettability, polarity, dipole moment and other properties would provide a powerful approach to prepare functional organic devices. © 2024 Elsevier LtdPamukkale University Scientific Research Projects Unit; ITO; SA-Azo-SH, (50–52); Türkiye Bilimsel ve Teknolojik Araştırma Kurumu, TÜBİTAK, (119Z618); Türkiye Bilimsel ve Teknolojik Araştırma Kurumu, TÜBİTAK; PAU-BAP, (2023ÖNAP001

Conjugated and fluorescent polymer based on dansyl-substituted carbazole: Investigation of electrochromic and ion sensitivity performance

Fluorescent conjugated polymers have been used as excellent optical sensing materials to develop high sensitive and selective sensors by using their large extinction coefficient and high fluorescence quantum yield. Thanks to these features, conjugated polymers are used in a wide range of applications, including metal ion sensing and detection. In this study, a dansyl-substituted fluorescent polycarbazole was synthesized by electrochemical polymerization of 9H-carbazol-2-yl 5-(dimethylamino)naphthalene-1-sulfonate (CZD). CZD was characterized by 1H-NMR, FT-IR, UV-vis and fluorescence spectroscopy. Optical and electrochemical properties of polymer (PCZD) were investigated by voltammetric, spectroelectrochemical, kinetic studies and colorimetry measurements. Polymer showed a reversible electrochromic behavior from green to light yellow color. Moreover, the sensitivities of CZD toward metal cations were examined by observing the change in the fluorescence intensity. CZD was found to be selective toward Zn2+ with significant quenching emission intensity while the other metal ions did not show any interaction with CZD. This novel monomer CZD can be used as metal ion sensor, besides PCZD used in good electronic and optical applications. © 2017 The Electrochemical Society. All rights reserved