Amyloid and tau pathology associations with personality traits, neuropsychiatric symptoms, and cognitive lifestyle in the preclinical phases of sporadic and autosomal dominant Alzheimer’s disease

Background Major prevention trials for Alzheimer’s disease (AD) are now focusing on multidomain lifestyle interventions. However, the exact combination of behavioral factors related to AD pathology remains unclear. In 2 cohorts of cognitively unimpaired individuals at risk of AD, we examined which combinations of personality traits, neuropsychiatric symptoms, and cognitive lifestyle (years of education or lifetime cognitive activity) related to the pathological hallmarks of AD, amyloid-β, and tau deposits. Methods A total of 115 older adults with a parental or multiple-sibling family history of sporadic AD (PREVENT-AD [PRe-symptomatic EValuation of Experimental or Novel Treatments for AD] cohort) underwent amyloid and tau positron emission tomography and answered several questionnaires related to behavioral attributes. Separately, we studied 117 mutation carriers from the DIAN (Dominant Inherited Alzheimer Network) study group cohort with amyloid positron emission tomography and behavioral data. Using partial least squares analysis, we identified latent variables relating amyloid or tau pathology with combinations of personality traits, neuropsychiatric symptoms, and cognitive lifestyle. Results In PREVENT-AD, lower neuroticism, neuropsychiatric burden, and higher education were associated with less amyloid deposition (p = .014). Lower neuroticism and neuropsychiatric features, along with higher measures of openness and extraversion, were related to less tau deposition (p = .006). In DIAN, lower neuropsychiatric burden and higher education were also associated with less amyloid (p = .005). The combination of these factors accounted for up to 14% of AD pathology. Conclusions In the preclinical phase of both sporadic and autosomal dominant AD, multiple behavioral features were associated with AD pathology. These results may suggest potential pathways by which multidomain interventions might help delay AD onset or progression

Strategy for the management of diabetic macular edema: the European Vitreo-Retinal Society macular edema study

Objective. To compare the efficacy of different therapies in the treatment of diabetic macular edema (DME). Design. Nonrandomized, multicenter clinical study. Participants. 86 retina specialists from 29 countries provided clinical information on 2,603 patients with macular edema including 870 patients with DME. Methods. Reported data included the type and number of treatment(s) performed, the pre-and posttreatment visual acuities, and other clinical findings.The results were analyzed by the French INSEE (National Institute of Statistics and Economic Studies). Main Outcome Measures. Mean change of visual acuity and mean number of treatments performed. Results.The change in visual acuity over time in response to each treatment was plotted in second order polynomial regression trend lines. Intravitreal triamcinolone monotherapy resulted in some improvement in vision. Treatmentwith threshold or subthreshold grid laser also resulted in minimal vision gain. Anti-VEGF therapy resulted in more significant visual improvement. Treatment with pars plana vitrectomy and internal limiting membrane (ILM) peeling alone resulted in an improvement in vision greater than that observed with anti-VEGF injection alone. In our DME study, treatment with vitrectomy and ILM peeling alone resulted in the better visual improvement compared to other therapies

of Dansyl Fluorophore Functionalized PEDOT

Fluorescent conducting polymers are gaining increasing popularity in actual applications such as electrochromic device, cell detection and fluorescence sensor. This paper describes the synthesis of new both fluorescent and electrochromic polymer. A new bifunctional material 2,3-dihydrothieno[3,4-b][1,4]dioxin-2-yl)methyl 5-(dimethylamino)naphthalene-1-sulfonate (ED) has been synthesized, characterized and electropolimerized. The polymer film which obtained as a highly stable conducting polymer on ITO glass was characterized by cyclic voltammetry (CV), colorimetry, UV-Vis spectroscopy, fluorescence spectroscopy, fluorescence microscopy and scanning electron microscopy (SEM). The PED film demonstrated light blue, gray and purplish blue colors as well as turquoise blue fluorescence color. Both CV and spectroelectrochemical studies proved that the PED film has exhibited high stable electro activity (98%). Further kinetic studies presented that the PED revealed high optic contrast (36%) and relatively low electrochromic response time (2.0 s). The results prevailed that the PED film is promising candidates for fluorescent detection and device applications. (c) 2017 The Electrochemical Society. All rights reserved

An Electrochemical Sensor Platform for Sensitive Detection of Iron (III) Ions Based on Pyrene-Substituted Poly(2,5-dithienylpyrrole)

Conducting polymers, which have a great potential for use in many technological application areas, can be used to design new selective, sensitive, highly efficient and practical sensor platforms. Herein, a pyrene-substituted 2,5-dithienylpyrrole (TPP) has been synthesized and its conductive polymer has been coated electrochemically on the ITO electrode surface to form a new sensor platform. After electrochemical and surface characterization of conducting polymer based sensor platform, its electrochemical responses to different metal ions have been investigated in aqueous media. It has been determined that P(TPP) displays excellent potentiometric response to Fe(III) ions while there is no significant electrochemical signal observed in other metal ion solutions including Fe(II), Zn(II), Cu(II), Hg(II), Cd(II). P(TPP) sensor platform has exhibited high stability, sensitivity, reproducibility toward the determination of Fe(III) with a good detection limit of 1.73 × 10−7 M. The sensor platform has great potential for disposable low-cost metal ion sensing platform which is convenient in-field testing application could be used in aqueous and biological samples. © 2019 The Electrochemical Society

Conjugated and fluorescent polymer based on dansyl-substituted carbazole: Investigation of electrochromic and ion sensitivity performance

Fluorescent conjugated polymers have been used as excellent optical sensing materials to develop high sensitive and selective sensors by using their large extinction coefficient and high fluorescence quantum yield. Thanks to these features, conjugated polymers are used in a wide range of applications, including metal ion sensing and detection. In this study, a dansyl-substituted fluorescent polycarbazole was synthesized by electrochemical polymerization of 9H-carbazol-2-yl 5-(dimethylamino)naphthalene-1-sulfonate (CZD). CZD was characterized by 1H-NMR, FT-IR, UV-vis and fluorescence spectroscopy. Optical and electrochemical properties of polymer (PCZD) were investigated by voltammetric, spectroelectrochemical, kinetic studies and colorimetry measurements. Polymer showed a reversible electrochromic behavior from green to light yellow color. Moreover, the sensitivities of CZD toward metal cations were examined by observing the change in the fluorescence intensity. CZD was found to be selective toward Zn2+ with significant quenching emission intensity while the other metal ions did not show any interaction with CZD. This novel monomer CZD can be used as metal ion sensor, besides PCZD used in good electronic and optical applications. © 2017 The Electrochemical Society. All rights reserved

amino carbazole

Triazine cored 3-amino-9ethly-carbazole (TAC) was designed, synthesized and characterized to constitute a new chemosensor for detecting Cu2+ with high selectivity over different metal ions. Besides, the optimized geometry of TAC was determined. Through TAC-Cu2+ interaction, TAC depicted a detectable absorbance and fluorescence signal shifting. This interaction was related to binding between -NH group of TAC and Cu2+ ion. Furthermore, stoichiometric ratio of TAC-Cu2+ determined using Job's plot as 3:2 (Cu2+ : TAC). Consequently, TAC fluorescent chemosensor for Cu2+ ions is important study for environmental and biological studies.C1 [Ayranci, Rukiye; Ak, Metin] Pamukkale Univ, Fac Art & Sci, Chem Dept, Denizli, Turkey.[Karatas, Erhan] Pamukkale Univ, Technol Fac, Met & Mat Engn Dept, Denizli, Turkey