Plio-Pleistocene Depositional Sequences of the Southwestern Louisiana Continental Shelf and Slope: Geologic Framework, Sedimentary Facies and Hydrocarbon Distribution

The Plio-Pleistocene hydrocarbon fairway of offshore Louisiana is restricted to the outer continental shelf and upper continental slope where a thick wedge of nearshore and deep marine sediments was deposited. Electric logs, paleontological reports, and seismic profiles form the basis for (1) dividing the wedge of Plio-Pleistocene strata into eight genetic sequences, (2) establishing the structural framework, (3) determining the timing of deformation, and (4) mapping the principal depositional systems of the West Cameron and western Garden Banks areas during the past five million years. Sedimentary facies and structural styles in this part of the basin are highly variable owing to contemporaneous sea-level fluctuations, salt migration, and shifting sites of deltaic, shelf, and slope sedimentation. The resulting complex geologic history of this part of the basin directly controlled the generation, migration, and entrapment of hydrocarbons. The early Pliocene was a period of continental platform inundation and deposition of a thick succession of marine mudstones. About 3 Ma, this monotonous accumulation of deep-water mudstone was interrupted by deposition of sand-rich submarine channels and fans associated with a lowering of sea level. These lowstand deposits extended at least 55 mi (90 km) basinward of the paleomargin. Overlying Pleistocene sediments were deposited mainly by prograding mud-rich fluvial-deltaic systems of moderate size. These rivers and shelf-edge deltas constructed a broad continental platform that buried the submarine fans and prograded the shelf margin approximately 70 mi (110 km) basinward. During this rapid outbuilding, slumping and other gravity-driven mass transport processes removed sand-rich delta-front sediments from unstable shelf margins and redeposited them on the continental slope.Bureau of Economic Geolog

Plio-Pleistocene Depositional Sequences of the Southwestern Louisiana Continental Shelf and Slope: Geologic Framework, Sedimentary Facies and Hydrocarbon Distribution

The Plio-Pleistocene hydrocarbon fairway of offshore Louisiana is restricted to the outer continental shelf and upper continental slope where a thick wedge of nearshore and deep marine sediments was deposited. Electric logs, paleontological reports, and seismic profiles form the basis for (1) dividing the wedge of Plio-Pleistocene strata into eight genetic sequences, (2) establishing the structural framework, (3) determining the timing of deformation, and (4) mapping the principal depositional systems of the West Cameron and western Garden Banks areas during the past five million years. Sedimentary facies and structural styles in this part of the Gulf Coast basin are highly variable owing to contemporaneous sea-level fluctuations, salt migration, and shifting sites of deltaic, shelf, and slope sedimentation. The resulting complex geologic history of this part of the basin was interpreted to determine what controlled the generation, migration, and entrapment of hydrocarbons. The early Pliocene was a period of continental platform inundation and deposition of a thick succession of marine mudstones. About 3 million years ago, this monotonous accumulation of deep-water mudstone was interrupted by deposition of sand-rich submarine channels and fans associated with a lowering of sea level. These lowstand deposits extended at least 55 miles (90 km) basinward of the paleomargin. Overlying Pleistocene sediments were deposited mainly by prograding mud-rich fluvial-deltaic systems of moderate size. These rivers and shelf-edge deltas constructed a broad continental platform that buried the submarine fans and prograded the shelf margin approximately 70 miles (110 km) basinward. During this rapid outbuilding, slumping and other gravity-driven mass transport processes removed sand-rich delta-front sediments from unstable shelf margins and redeposited them on the continental slope.Bureau of Economic Geolog

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Efficacy and safety of pharmacotherapies for smoking cessation in anxiety disorders: Subgroup analysis of the randomized, active- and placebo-controlled EAGLES trial.

BackgroundSmoking rates are high in adults with anxiety disorders (ADs), yet little is known about the safety and efficacy of smoking-cessation pharmacotherapies in this group.MethodsPost hoc analyses in 712 smokers with AD (posttraumatic stress disorder [PTSD], n = 192; generalized anxiety disorder [GAD], n = 243; panic disorder [PD], n = 277) and in a nonpsychiatric cohort (NPC; n = 4,028). Participants were randomly assigned to varenicline, bupropion, nicotine-replacement therapy (NRT), or placebo plus weekly smoking-cessation counseling for 12 weeks, with 12 weeks follow-up. General linear models were used to test the effects of treatment group, cohort, and their interaction on neuropsychiatric adverse events (NPSAEs), and continuous abstinence weeks 9-12 (treatment) and 9-24 (follow-up).ResultsNPSAE incidence for PTSD (6.9%), GAD (5.4%), and PD (6.2%) was higher versus NPC (2.1%), regardless of treatment. Across all treatments, smokers with PTSD (odds ratio [OR] = 0.58), GAD (OR = 0.72), and PD (OR = 0.53) had lower continuous abstinence rates weeks 9-12 (CAR9-12) versus NPC. Varenicline demonstrated superior efficacy to placebo in smokers with GAD and PD, respectively (OR = 4.53; 95% confidence interval [CI] = 1.20-17.10; and OR = 8.49; 95% CI = 1.57-45.78); NRT was superior to placebo in smokers with PD (OR = 7.42; 95% CI = 1.37-40.35). While there was no statistically significant effect of any treatment on CAR9-12 for smokers with PTSD, varenicline improved 7-day point prevalence abstinence at end of treatment in this subcohort.ConclusionIndividuals with ADs were more likely than those without psychiatric illness to experience moderate to severe NPSAEs during smoking-cessation attempts, regardless of treatment. While the study was not powered to evaluate abstinence outcomes with these subgroups of smokers with ADs, varenicline provided significant benefit for cessation in those with GAD and PD, while NRT provided significant benefit for those with PD