Biomimetic Nanocoating of Bone Plates

20th National Biomedical Engineering Meeting (BIYOMUT) -- NOV 03-05, 2016 -- Izmir, TURKEYWOS: 000404996800039Infection and nonunion following fracture fixation remain as unsolved problems of orthopaedic surgery. This condition may lead to implant failures and necessitate further surgical interventions, ending up with increased morbidity and treatment costs. In this study, 316L stainless steel bone plates were coated with stronsiyum containing bone like hydroxyapaptite (HA) (1. Layer) and silver enriched polylactic acid coating (2. Layer). Thus, firstly, 2.0 mm. routinely used fracture fixation plates were first coated by immersing strontium containing simulated body fluid (x10) in order to nanocoat with HA layer. Then, plates will be coated with Ag enriched PLA and their surface properties will were characterized

Biodegradable Poly(epsilon-Caprolactone)-Based Graft Copolymers Via Poly(Linoleic Acid): In Vitro Enzymatic Evaluation

WOS: 000350563400016Well-defined graft copolymers based on poly(epsilon-caprolactone) (PCL) via poly(linoleic acid) (PLina), are derived from soybean oil. Poly(linoleic acid)-g-poly(epsilon-caprolactone) (PLina-g-PCL) and poly(linoleic acid)-g-poly(styrene)-g-poly(epsilon-caprolactone) (PLina-g-PSt-g-PCL) were synthesized by ring-opening polymerization of epsilon-caprolactone initiated by PLina and one-pot synthesis of graft copolymers, and by ring-opening polymerization and free radical polymerization by using PLina, respectively. PLina-g-PCL, PLina-g-PSt-g-PCL3, and PLina-g-PSt-g-PCL4 copolymers containing 96.97, 75.04 and 80.34 mol% CL, respectively, have been investigated regarding their enzymatic degradation properties in the presence of Pseudomonas lipase. In terms of weight loss, after 1 month, 51.5 % of PLina-g-PCL, 18.8 % of PLina-g-PSt-g-PCL3, and 38.4 % of PLina-g-PSt-g-PCL4 were degraded, leaving remaining copolymers with molecular weights of 16,140, 83,220 and 70,600 Da, respectively. Introducing the PLina unit into the copolymers greatly decreased the degradation rate. The molar ratio of [CL]/[Lina] dramatically decreased, from 21.3 to 8.4, after 30 days of incubation. Moreover, reduced PCL content in PLina-g-PSt-g-PCL copolymers decreased the degradation rate, probably due to the PSt enrichment within the structure, which blocks lipase contact with PCL units. Thus, copolymerization of PCL with PLina and PSt units leads to a controllable degradation profile, which encourages the use of these polymers as promising biomaterials for tissue engineering applications.Turkish Scientific Research CouncilTurkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [110T884, 211T016]; Bulent Ecevit University Research FundBulent Ecevit University [2012-17-21-03]This work was supported financially by the Turkish Scientific Research Council (Grants Numbers: 110T884, 211T016) and Bulent Ecevit University Research Fund (Grant Number: 2012-17-21-03)