Retrospective comparison of flot and modified dcf as first-line chemotherapy in metastatic gastric adenocarcinoma

Background: The aim of our study was to compare the efficacy and the safety of the FLOT and the modified DCF (mDCF) regimens in patients with metastatic gastric (GC) and gastroesophageal junction (GEJ) adenocarcinoma as first-line treatment. Methods: The medical records of 72 patients were retrospectively reviewed. Survivals and hematological adverse events of the patients were examined. Factors affecting survivals were analyzed in univariate analysis. A multivariate analysis was performed with the factors contributing to survivals in univariate analysis. Results: The median PFS (mPFS) was 10.1 months (95% CI, 6.8-13.4) in the FLOT arm (n = 33) and 7.4 months (95% CI, 9.1-21.6) in the mDCF arm (n = 39) (p = 0.041). The median OS (mOS) was 12.9 months (95% CI, 9.7-16.1) in the FLOT arm and 15.4 months (95% CI, 9.1-21.6) in the mDCF arm (p = 0.622). It was found that all grade neutropenia was 51.3% vs. 72.7% (p = 0.063), febrile neutropenia was 8.3% vs. 6.3% (p = 0.743), and thrombocytopenia was 48.7% vs. 51.5% (p = 0.813) in the FLOT and mDCF arms, respectively. Anemia was 59% in the FLOT arm and 100% in the mDCF arm (p < 0.001). Grade 3-4 anemia was 7.7% in the FLOT arm and 24.2% in the mDCF arm (p = 0.052). Discussion: It was shown that the mPFS was significantly increased in the FLOT arm compared to the mDCF arm as the first-line treatment in patients with metastatic GC and GEJC. Hematological adverse events were more favorable in the FLOT arm than in the mDCF arm

Everolimus Treatment and Selective Artery Embolization Application in a Case of Tuberous Sclerosis-Related Bilateral Renal Angiomyolipoma

Angiomyolipomas are the most common benign mesenchymal tumors of the kidney. Although they are often seen sporadically, they can also be observed as a part of the tuberous sclerosis complex (TSC). They occur at an earlier age in cases associated with tuberous sclerosis (TS), bilateral mass and epithelioid formation. There are various treatment approaches such as active surveillance, nephron-sparing surgery, nephrectomy, angioembolization, and use of mammalian target of rapamycin (mTor) inhibitors. Our case was a patient with bilateral multiple renal angiomyolipomas associated with TS. We applied mTOR inhibitor and angioembolization therapy to this patient. In our article, we tried to evaluate our success rate in our treatment and the treatment regimens to be applied in these patients

Diagnostic Role of Intravesical Prostatic Protrusion and Visual Prostate Symptom Score in Lower Urinary Tract Symptoms in Male

INTRODUCTION: In this study, it was aimed to evaluate non-invasive, effective and low-cost diagnostic methods of bladder filling and voiding abnormalities in male patients. METHODS: Visual Prostate Symptom Score (VPSS) and the International Prostate Symptom Score (IPSS) were completed by the patients. Patients' intravesical prostatic protrusion (IPP), prostate volume, and post voiding residual urine (PVR) were measured by suprapubic ultrasound. Bladder Outlet Obstruction Number (BOON) was used to calculate urethral resistance. Patients with a BOON value above -20 were considered obstructive. RESULTS: This study included 219 male patients aged 50 years and over.The number of patients with a BOON value over -20 were 34 (obstructed) and below -20 were 61 (non-obstructed). There was a significant difference between these two groups in terms of PSA, prostate volume, IPP, Qmax, PVR, IPSS, and VPSS. It was observed that IPSS and VPSS were correlated (r=0.786, p=0.001). Obstructive (r=0.779, p=0.000) and irritative symptoms (r=0.813, p=0.000) of IPSS and VPSS were also observed to be correlated. DISCUSSION AND CONCLUSION: VPSS was found to be equivalent to IPSS in the diagnosis of lower urinary tract symptoms (p=0.001). IPP is an important, practical, and non-invasive method that correlates with IPSS, VPSS, and BOON

Traditional methods in ınfant care by parents to 0-24 months old babies

0-24 aylık bebeği olan ebeveynlerin, bebek bakımında uyguladıkları geleneksel yöntemlerin dağılımını belirlemek ve sosyodemografik faktörlerle ilişkisini incelemektir. Tanımlayıcı tip araştırmaya, Eylül-Ekim 2018 tarihlerinde, Denizli Pamukkale Üniversitesi Tıp Fakültesi Hastanesinin pediatri polikliniklerine başvuran, 0-24 ay çocuğu olan ebeveynler dahil edilmiştir. Örneklem büyüklüğü 384 hesaplanmıştır. Çalışmaya gönüllü katılımcılara yüz yüze görüşme tekniği ile 56 sorudan oluşan bir soru formu uygulanarak veriler toplanmıştır. SPSS 15 programı ile veriler analiz edilmiştir. Araştırmaya 351 kişi katılmıştır (%91,4). Anne yaş ortalaması 29,4±5,6; baba yaş ortalaması 32,7±5,9 ‘dur. 0-24 ay arasında çocuğu olan ebeveynlerin %97,2’si bebek bakımında en az bir geleneksel yöntem uyguladığını belirtmiştir. En fazla uygulanan üç geleneksel yöntem sırasıyla tuzlama (%65,0), nazardan korunma (%49,9) ve perine bakımı (%46,2) ile ilgili yöntemlerdir. Anne yaşının genç olması (p=0,002), aile büyükleri ile birlikte yaşamak (p=0,008), bebek bakımı konusunda bilgileri kitap dışı kaynaklardan öğrenmek (p=0,016) bebek bakımında geleneksel yöntemleri uygulamada bağımsız risk faktörleridir (p<0,05). Geleneksel yöntemler ebeveynlerin büyük çoğunluğu tarafından bebek bakımında uygulanmaktadır.To determine the distribution of the traditional methods used in infant care by parents with 0-24 months old infants and to investigate their relationship with sociodemographic factors. A descriptive study was conducted between September and October 2018 in a pediatric outpatient clinic of Denizli Pamukkale University Medical Faculty Hospital. The sample size was calculated as 384. Data were collected by applying a questionnaire consisting of 56 questions to the volunteer participants using a face-to-face interview technique Data were analyzed with SPSS 15 program. The study had 351 participants (91.4%). The mean age of the mothers was 29.4 ± 5.6; the mean age of the fathers was 32.7 ± 5.9 years. Of the parents, 97.2% who have children between 0-24 months stated that they used at least one traditional method in baby care. The three most commonly used methods were salting (65.0%), protection from evil eye (49.9%) and perineal care (46.2%), respectively. Lower maternal age (P=0,002), living with grandparents (p=0,008), learning about infant care from nonbook sources (p=0,016) are independent risk factors in applying traditional methods of infant care (p<0,05). Conventional methods are used by the majority of parents in infant care

Carbapenem-resistant Klebsiella pneumoniae meningitis: A case report

WOS: 000384332700020PubMed ID: 2581740

Validity and reliability of the Turkish version of the DSM-5 Generalized Anxiety Disorder Severity Scale for children aged 11-17 years

Background/aim: This study aimed to assess the validity and reliability of the Turkish version of the DSM-5 Generalized Anxiety Disorder Severity Scale - Child Form

DATÇA VE HİSARÖNÜ KÖRFEZLERİNİN GÜNCEL SEDİMANLARINDA TANE BOYU, TOPLAM AĞIR MİNERAL VE ELEMENT DAĞILIMLARI İLE BUNLARI KONTROL EDEN FAKTÖRLER

Türkiye’nin güney batısında ve Datça Yarımadası’nın güneyinde yer alan Datça ve Hisarönü Körfezlerinde Holosen sedimantasyon süreçlerini ve kontrol eden faktörleri araştırmak amacı ile 2013 yılında MTA-SELEN Araştırma Gemisi ile Datça ve Hisarönü Körfezlerinin tabanından 71 nokta istasyonda kepçe ile yüzeysel (üst 30 cm) sediman örnekleri alınmıştır. Sedimanlarda tane boyu, toplam ağır mineral ve ana element analizleri yapılmıştır. Kıyıya dik alınan sismik kesitte sismik fasiyes analizleri yapılmıştır. Analizlerde bilinen ve yaygın uygulanan yöntem ve teknikler kullanılmıştır. Sismik kesite göre, kıtasal şelf kenarı ya da eşiği günümüzde -90/-120 m su derinliklerinde bulunmakta ve Kuvaterner dönemine ait deniz seviyesi değişimlerini gösterir sismik fasiyes özelliklerini sergilemektedir. Radyokarbon yaşlandırma hesaplamaları, sediman örneklerinin günümüzden 2694-14700 yıl önce çökelmeye başladıklarını işaret etmektedir.Deniz tabanı sedimanları %1-18 arasında çakıl, %7-85 kum, %2-30 silt ve %6-69 kil boyu kırıntılı malzemeden oluşmaktadır. Silt ve kil karışımı çamur en bol bulunan sediman türü olmasına rağmen yer yer kum ve çakıl oranları da önem teşkil etmektedir. Alansal tane boyu dağılımlarında bölgesel farklılıklar olduğu gibi, kalıntı (relik) sedimanların varlığı da tartışılmaktadır. Siyah kumca zengin toplam ağır mineral miktarları çoğunlukla %2’nin altında olup, ofiyolit ve kromitçe zengin orta ve doğu bölgelerde %13’e kadar yükselmektedir. Sedimanların inorganik jeokimyası göreceli olarak yüksek ve ofiyolitik kökenli Mg, Cr, Ni ve Fe miktarları ile belirgindir.  Bölgedeki akarsu drenaj sistemleri, körfez morfolojisi, kaynak alan kayaçlarının litolojisi ve denizel dalga ve akıntılar sedimanlardaki tane boyu dağılımını, toplam ağır mineral oranlarını ve ana element bileşimini etkileyen faktörlerdir

Validity and reliability of the Turkish version of the DSM-5 Generalized Anxiety Disorder Severity Scale for children aged 11–17 years

Background/aim: This study aimed to assess the validity and reliability of the Turkish version of the DSM-5 Generalized Anxiety Disorder Severity Scale - Child Form

Validity and reliability of the Turkish version of the DSM-5 Separation Anxiety Disorder Severity Scale–child form

OBJECTIVE: This study aimed to assess the validity and reliability of the Turkish version of the DSM-5 Separation Anxiety Disorder Severity Scale–Child Form. METHODS: The scale was prepared by carrying out translation and back-translation of the DSM-5 Separation Anxiety Disorder Severity Scale–Child Form. The study group consisted of 41 patients who had been treated in a child psychiatry unit and diagnosed with separation anxiety disorder and 100 healthy volunteers who were attending middle or high school during the study period. For the assessment, Screen for Childhood Anxiety and Related Emotional Disorders (SCARED) was also used, along with the DSM-5 Separation Anxiety Disorder Severity Scale–Child Form. RESULTS: The Cronbach alpha internal consistency coefficient was calculated as 0.932, while the item–total score correlation coefficients were between 0.400 and 0.874. One factor that could explain 63% of the variance was obtained. The scale showed a medium correlation with SCARED. The area under the receiver operating characteristic curve was calculated as 0.898. CONCLUSION: It was concluded that the Turkish version of DSM-5 Separation Anxiety Disorder Severity Scale–Child Form could be used as a valid and reliable tool both in clinical practice and for research purposes

Validity and Reliability of the Turkish Version of the DSM- 5 "Severity Measure for Agoraphobia-Child Age 11-17"

Objective: This study aimed to assess the validity and reliability of the Turkish version of the DSM-5 "Severity Measure for Agoraphobia-Child Age 11-17"