Design and Analysis of Dual Pressure Probes for Predicting Turbulence-Induced Vibration in Low Velocity Flow

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/97074/1/AIAA2012-1881.pd

Cloud Ice Properties: In Situ Measurement Challenges

Baumgardner D., S.J. Abel, D. Axisa, R. Cotton, J. Crosier, P. Field, C. Gurganus, A. Heymsfield, A. Korolev, M. Krämer, P. Lawson, G. McFarquhar, Z. Ulanowski, and J. Um, 'Cloud ice properties: in situ measurement challenges', Meteorological Monographs, Vol. 58, pp. 9.1–9.23, April 2017. The version of record is available online at doi: 10.1175/AMSMONOGRAPHS-D-16-0011.1.1 © 2017 American Meteorological Society. For information regarding reuse of this content and general copyright information, consult the AMS Copyright Policy (www.ametsoc.org/PUBSReuseLicenses).Understanding the formation and evolution of ice in clouds requires detailed information on the size, shape, mass and optical properties of individual cloud hydrometeors and their bulk properties over a broad range of atmospheric conditions. Since the 1960s, instrumentation and research aircraft have evolved providing increasingly more accurate and larger quantities of data about cloud particle properties. In this chapter we review the current status of electrical powered, in situ measurement systems with respect to their strengths and weaknesses and document their limitations and uncertainties. There remain many outstanding challenges. These are summarized and accompanied by recommendations for moving forward. through new developments that fill the remaining information gaps. Closing these gaps will remove the obstacles that continue to hinder our understanding of cloud processes in general and the evolution of ice in particular.Peer reviewe

Activator protein-1 (AP-1) signalling in human atherosclerosis: results of a systematic evaluation and intervention study

Animal studies implicate the AP-1 (activator protein-1) pro-inflammatory pathway as a promising target in the treatment of atherosclerotic disease. It is, however, unclear whether these observations apply to human atherosclerosis. Therefore we evaluated the profile of AP-1 activation through histological analysis and tested the potential benefit of AP-1 inhibition in a clinical trial. AP-1 activation was quantified by phospho-c-Jun nuclear translocation (immunohistochemistry) on a biobank of aortic wall samples from organ donors. The effect of AP-1 inhibition on vascular parameters was tested through a double blind placebo-controlled cross-over study of 28 days doxycycline or placebo in patients with symptomatic peripheral artery disease. Vascular function was assessed by brachial dilation as well as by plasma samples analysed for hs-CRP (high-sensitivity C-reactive protein), IL-6 (interleukin-6), IL-8, ICAM-1 (intercellular adhesion molecule-1), vWF (von Willebrand factor), MCP-1 (monocyte chemoattractant protein-1), PAI-1 (plasminogen activator inhibitor-1) and fibrinogen. Histological evaluation of human atherosclerosis showed minimal AP-1 activation in non-diseased arterial wall (i.e. vessel wall without any signs of atherosclerotic disease). A gradual increase of AP-1 activation was found in non-progressive and progressive phases of atherosclerosis respectively (P<0.044). No significant difference was found between progressive and vulnerable lesions. The expression of phospho-c-Jun diminished as the lesion stabilized (P<0.016) and does not significantly differ from the normal aortic wall (P<0.33). Evaluation of the doxycycline intervention only revealed a borderline-significant reduction of circulating hs-CRP levels (−0.51 μg/ml, P=0.05) and did not affect any of the other markers of systemic inflammation and vascular function. Our studies do not characterize AP-1 as a therapeutic target for progressive human atherosclerotic disease

On the Other Side of Simulation: Evaluating Faculty Debriefing Styles

Background: Debriefing after simulation facilitates reflection and the ability to transfer learning into clinical practice. Aim: To evaluate faculty debriefing to inform and guide the development of ongoing resources to support adjunct faculty members and to maximise learning potential for students. Method: Faculty debriefing styles were evaluated following a high-fidelity simulation involving 720 first year undergraduate nursing students. One audio recording of a debrief was randomly selected from each of 12 faculty members. If a pre-brief was completed prior to the simulation, this was also selected as it is a component of the debrief and sets the tone prior to the simulation. Initial analysis was undertaken using the validated observational structured assessment of debriefing tool (OSAD) to briefly highlight different debriefing styles. This facilitated the thematic analysis of the data using Braun and Clarkes (2006) six step process. Results: Nursing faculty used open-ended questions, silence and clinical feedback with varying levels of expertise and success. Conclusions: Further research into the effect on the variation in debriefing styles, and it's related impact on student learning outcomes is needed

Burnout and distress in Australian physician trainees: Evaluation of a wellbeing workshop

© The Royal Australian and New Zealand College of Psychiatrists 2019. Objective: To evaluate the effectiveness of a workshop intervention to promote wellbeing for Australian physician trainees using a randomized-controlled design. Methods: Participants were randomly assigned into intervention and control groups. The intervention group attended a half-day workshop. Outcome measures included depression anxiety stress scale, professional quality of life scale and alcohol use disorders identification test. Demographic and work/life factors were measured. Measurements were recorded at baseline, 3 and 6 months, and the workshop was evaluated by participants. Results: High rates of burnout (76%) and secondary traumatic stress (91%) were detected among study participants and around half met screening criteria for depression (52%), anxiety (46%) and stress (50%) at baseline. Workshop evaluations showed that participants agreed that the training was relevant to their needs (96%) and met their expectations (92%). There was a small reduction in alcohol use, depression and burnout in the intervention group compared with the control group at 6 months, but these changes did not reach statistical significance. Conclusion: High rates of psychological morbidity detected in the study suggest that physician trainees are a vulnerable group who may benefit from initiatives that promote wellbeing and changes in the workplace to reduce distress