The influence of burnout on cardiovascular disease: a systematic review and meta-analysis

BackgroundBurnout is a public health problem with various health consequences, among which cardiovascular disease is the most investigated but still under debate. Our objective was to conduct a systematic review and meta-analysis on the influence of burnout on cardiovascular disease.MethodsStudies reporting risk (odds ratio, relative risk, and hazard ratio) of cardiovascular disease following burnout were searched in PubMed, PsycINFO, Cochrane, Embase, and ScienceDirect. We performed a random-effect meta-analysis stratified by type of cardiovascular disease and searched for putative influencing variables. We performed sensitivity analyses using the most adjusted models and crude risks.ResultsWe included 25 studies in the systematic review and 9 studies in the meta-analysis (4 cross-sectional, 4 cohort, and 1 case–control study) for a total of 26,916 participants. Burnout increased the risk of cardiovascular disease by 21% (OR = 1.21, 95% CI 1.03 to 1.39) using the most adjusted risks and by 27% (OR = 1.27, 95% CI 1.10 to 1.43) using crude risks. Using stratification by type of cardiovascular disease and the most adjusted risks, having experienced burnout significantly increased the risk of prehypertension by 85% (OR = 1.85, 95% CI 1.00 to 2.70) and cardiovascular disease-related hospitalization by 10% (OR = 1.10, 95% CI 1.02 to 1.18), whereas the risk increase for coronary heart disease (OR = 1.79, 95% CI 0.79 to 2.79) and myocardial infarction (OR = 1.78, 95% CI 0.85 to 2.71) was not significant. Results were also similar using crude odds ratio. The risk of cardiovascular disease after a burnout was not influenced by gender. Insufficient data precluded other meta-regressions.ConclusionsBurnout seems to increase the risk of cardiovascular disease, despite the few retrieved studies and a causality weakened by cross-sectional studies. However, numerous studies focused on the pathophysiology of cardiovascular risk linked to burnout, which may help to build a preventive strategy in the workplace

Influence du burnout sur les maladies cardiovasculaires : revue systématique et méta-analyse

Background: burnout is a public health problem with various health consequences, among which cardiovascular disease is the most investigated but still under debate. Our objective was to conduct a systematic review and meta-analysis on the influence of burnout on cardiovascular disease.Method: studies reporting risk (odds ratio, relative risk, hazard ratio) of cardiovascular disease following burnout were searched in PubMed, PsycInfo, Cochrane, Embase, and ScienceDirect. We performed a random-effect meta-analysis stratified by type of cardiovascular disease and search for putative influencing variables. We performed sensitivity analyses using the most adjusted models and crude risks.Results: we included 25 studies in the systematic review, and nine studies in the meta-analysis for a total of 26 916 participants. Burnout increased the risk of cardiovascular disease by 21% (OR=1.21, 95CI 1.03 to 1.39) using the most adjusted risks and by 27% (OR=1.27, 95CI 1.10 to 1.43) using crude risks. Using stratification by type of cardiovascular disease and the most adjusted risks, having experienced burnout significantly increased the risk of prehypertension by 85% (OR=1.85, 95CI 1.00 to 2.70), and cardiovascular disease-related hospitalization by 10% (OR=1.10, 95CI 1.02 to 1.18); whereas the risk increase for coronary heart disease (OR=1.79, 95CI 0.79 to 2.79) and myocardial infarction (OR=1.78, 95CI 0.85 to 2.71) were not significant. Results were also similar using crude odds ratio. The risk of cardiovascular disease after a burnout was not influenced by gender. Insufficient data precluded other metaregressions.Conclusion: burnout seems to increase the risk of cardiovascular disease, despite the few retrieved studies. However, numerous studies focused on the pathophysiology of the cardiovascular risk linked with burnout that may help to build preventive strategy in the workplace.Contexte : le burnout est un problème de santé publique avec de multiples conséquences, notamment sur le risque de maladies cardiovasculaires, bien que cela ne soit pas consensuel. Notre objectif était deréaliser une revue systématique et une méta-analyse sur l'influence du burnout sur les maladies cardiovasculaires.Méthode : les études rapportant un risque (odds ratio, risque relatif, hazard ratio) de maladies cardiovasculaires suite à un burnout ont été recherchées dans les bases de données PubMed, PsycInfo, Cochrane, Embase, et ScienceDirect. Nous avons effectué une méta-analyse à effet aléatoire stratifiée par type de maladies cardiovasculaires et nous avons recherché l’influence de certaines variables. Nousavons effectué des analyses de sensibilité en utilisant les risques les plus ajustés et les risques bruts.Résultats : nous avons inclus 25 études dans la revue systématique et 9 études dans la méta-analyse pour un total de 26 916 participants. Le burnout augmente le risque de maladies cardiovasculaires de21 % (OR = 1,21, 95CI 1,03 à 1,39) en utilisant les risques les plus ajustés et de 27 % (OR = 1,27, 95CI 1,10 à 1,43) en utilisant les risques bruts. En utilisant la stratification par type de maladies cardiovasculaires et les risques les plus ajustés, le burnout augmente significativement le risque de préhypertension de 85 % (OR = 1,85, 95CI 1,00 à 2,70), et d'hospitalisation pour maladie cardiovasculaire de 10 % (OR = 1,10, 95CI 1,02 à 1,18) ; alors que l'augmentation du risque de maladie coronarienne (OR = 1,79, 95CI 0,79 à 2,79) et d'infarctus du myocarde (OR = 1,78, 95CI 0,85 à 2,71) ne sont pas significative. Les résultats sont également similaires en utilisant les risques bruts. Le risque de maladies cardiovasculaires après un burnout n’est pas influencé par le sexe. L’insuffisance des données a empêché d'autres méta-régressions.Conclusion : malgré le peu d'études retrouvées, le burnout semble augmenter le risque de maladies cardiovasculaires, Toutefois, de nombreuses études ont étudié la physiopathologie du risque cardiovasculaire lié au burnout, ce qui pourrait aider à élaborer des stratégies de prévention

The influence of burnout on cardiovascular disease:a systematic review and meta-analysis

Background: Burnout is a public health problem with various health consequences, among which cardiovascular disease is the most investigated but still under debate. Our objective was to conduct a systematic review and meta-analysis on the influence of burnout on cardiovascular disease. Methods: Studies reporting risk (odds ratio, relative risk, and hazard ratio) of cardiovascular disease following burnout were searched in PubMed, PsycINFO, Cochrane, Embase, and ScienceDirect. We performed a random-effect meta-analysis stratified by type of cardiovascular disease and searched for putative influencing variables. We performed sensitivity analyses using the most adjusted models and crude risks. Results: We included 25 studies in the systematic review and 9 studies in the meta-analysis (4 cross-sectional, 4 cohort, and 1 case–control study) for a total of 26,916 participants. Burnout increased the risk of cardiovascular disease by 21% (OR = 1.21, 95% CI 1.03 to 1.39) using the most adjusted risks and by 27% (OR = 1.27, 95% CI 1.10 to 1.43) using crude risks. Using stratification by type of cardiovascular disease and the most adjusted risks, having experienced burnout significantly increased the risk of prehypertension by 85% (OR = 1.85, 95% CI 1.00 to 2.70) and cardiovascular disease-related hospitalization by 10% (OR = 1.10, 95% CI 1.02 to 1.18), whereas the risk increase for coronary heart disease (OR = 1.79, 95% CI 0.79 to 2.79) and myocardial infarction (OR = 1.78, 95% CI 0.85 to 2.71) was not significant. Results were also similar using crude odds ratio. The risk of cardiovascular disease after a burnout was not influenced by gender. Insufficient data precluded other meta-regressions. Conclusions: Burnout seems to increase the risk of cardiovascular disease, despite the few retrieved studies and a causality weakened by cross-sectional studies. However, numerous studies focused on the pathophysiology of cardiovascular risk linked to burnout, which may help to build a preventive strategy in the workplace.</p

Presentation_1_The influence of burnout on cardiovascular disease: a systematic review and meta-analysis.pdf

BackgroundBurnout is a public health problem with various health consequences, among which cardiovascular disease is the most investigated but still under debate. Our objective was to conduct a systematic review and meta-analysis on the influence of burnout on cardiovascular disease.MethodsStudies reporting risk (odds ratio, relative risk, and hazard ratio) of cardiovascular disease following burnout were searched in PubMed, PsycINFO, Cochrane, Embase, and ScienceDirect. We performed a random-effect meta-analysis stratified by type of cardiovascular disease and searched for putative influencing variables. We performed sensitivity analyses using the most adjusted models and crude risks.ResultsWe included 25 studies in the systematic review and 9 studies in the meta-analysis (4 cross-sectional, 4 cohort, and 1 case–control study) for a total of 26,916 participants. Burnout increased the risk of cardiovascular disease by 21% (OR = 1.21, 95% CI 1.03 to 1.39) using the most adjusted risks and by 27% (OR = 1.27, 95% CI 1.10 to 1.43) using crude risks. Using stratification by type of cardiovascular disease and the most adjusted risks, having experienced burnout significantly increased the risk of prehypertension by 85% (OR = 1.85, 95% CI 1.00 to 2.70) and cardiovascular disease-related hospitalization by 10% (OR = 1.10, 95% CI 1.02 to 1.18), whereas the risk increase for coronary heart disease (OR = 1.79, 95% CI 0.79 to 2.79) and myocardial infarction (OR = 1.78, 95% CI 0.85 to 2.71) was not significant. Results were also similar using crude odds ratio. The risk of cardiovascular disease after a burnout was not influenced by gender. Insufficient data precluded other meta-regressions.ConclusionsBurnout seems to increase the risk of cardiovascular disease, despite the few retrieved studies and a causality weakened by cross-sectional studies. However, numerous studies focused on the pathophysiology of cardiovascular risk linked to burnout, which may help to build a preventive strategy in the workplace.</p