11 research outputs found
PENGARUH LINGKUNGAN KERJA DAN REWARD TERHADAP MOTIVASI KERJA KARYAWAN DIVISI SENJATA PADA PT. PINDAD (PERSERO) KOTA BANDUNG
ABSTRAK
Penelitian ini dilakukan berdasarkan adanya permasalahan motivasi kerja
karyawan kurang efektif yang disebabkan oleh lingkungan kerja yang kurang
memadai dan reward yang belum sesuai dengan standar. Penelitian ini bertujuan
untuk mengetahui pengaruh lingkungan kerja dan reward terhadap motivasi
karyawan pada PT. Pindad Persero Divisi Senjata Kota Bandung. Metode penelitian
yang digunakan adalah metode deskriptif dan verifikatif. Teknik sampling yang
digunakan adalah probability sampling dengan jumlah sample 81 responden.
Teknik pegumpulan data yang digunakan adalah penelitian lapangan dan penelitian
kepustakaan. Metode analisi data yang digunakan adalah method of successive
interval, analisis regresi berganda, korelasi berganda dan koefisien determinasi.
Hasil penelitian menunjukan bahwa terdapat pegaruh positif dan signifikan
antara lingkungan kerja dan reward terhadap motivasi kerja karyawan pada PT.
Pindad Persero Divisi Senjata Kota Bandung baik secara simultan maupun parsial.
Besarnya pengaruh lingkungan kerja dan reward terhadap motivasi kerja karyawan
pada PT. Pindad Persero Divisi Senjata Kota Bandung secara simultan sebesar
63,8% dan sisanya 36,2% dipengaruhi variabel lain yang tidak diteliti. Secara
parsial besarnya pengaruh lingkungan kerja terhadap motivasi kerja karyawan
sebesar 40,4% dan pengaruh reward terhadap motivasi kerja karyawan sebesar
23,4%, sehingga dapat disimpulkan bahwa lingkungan kerja yang memberikan
pengaruh paling besar terhadap motivasi kerja karyawan.
Kata Kunci : Lingkungan Kerja, Reward dan Motivasi Kerj
Antiretroviral resistance in individuals presenting therapeutic failure and subtypes of the human immunodeficiency virus type 1 in the Northeast Region of Brazil
This study aimed to analyze human immunodeficiency virus (HIV) mutation
profiles related to antiretroviral resistance following therapeutic
failure, and the distribution of hiv subtypes in the Northeast Region
of Brazil. A total of 576 blood samples from AIDS patients presenting
therapeutic failure between 2002 and 2004 were analyzed. The genotyping
kit viroSeq® was used to perform viral amplification in order to
identify mutations related to hiv pol gene resistance. An index of
91.1% of the patients presented mutations for nucleoside reverse
transcriptase inhibitors (nrti), 58.7% for non-nucleoside reverse
transcriptase inhibitors (nnrti), and 94.8% for protease inhibitors
(pi). The most prevalent mutations were 184V and 215E for nrti, 103N
and 190A for nnrti. Most mutations associated with PIs were secondary,
but significant frequencies were observed in codons 90 (25.2%), 82
(21.1%), and 30 (16.2%). The resistance index to one class of
antiretrovirals was 14%, to two classes of antiretrovirals 61%, and to
three classes 18.9%. Subtype B was the most prevalent (82.4%) followed
by subtype F (11.8%). The prevalence of mutations related to nrti and
nnrti was the same in the two subtypes, but codon analysis related to
PI showed a higher frequency of mutations in codon 63 in subtype B and
in codon 36 in subtype F. The present study showed that there was a
high frequency of primary mutations, which offered resistance to nrti
and nnrti. Monitoring patients with treatment failure is an important
tool for aiding physicians in rescue therapy
Linfangioleiomiomatose pulmonar Pulmonary Lymphangioleiomyomatosis
Linfangioleiomiomatose pulmonar (LAM) é uma doença rara, de etiologia desconhecida, que basicamente afeta mulheres jovens no perÃodo fértil de sua vida. Clinicamente, manifesta-se através de dispnéia progressiva, pneumotórax de repetição, tosse seca e, menos freqüentemente, por quilotórax e escarros hemoptóicos. Essas alterações surgem devido à proliferação anormal de células de músculo liso no parênquima pulmonar, linfonodos e em outros tecidos. Mais recentemente, estudos citogenéticos verificaram a presença de mutações do gene TSC-2 em células de angiomiolipoma renal e linfonodos abdominais de pacientes com LAM, indicando uma possÃvel origem para as lesões hamartomatosas da doença. Radiologicamente, caracteriza-se pela presença de infiltrado intersticial reticulonodular e sinais de hiperinsuflação ao radiografia de tórax. Na tomografia computadorizada de alta resolução, cistos de paredes finas, localizados centralmente, são visibilizados por todo o parênquima do pulmão. O ultrassom e a tomografia de abdome podem revelar angiomiolipomas renais e linfonodomegalias retroperitoneais. Meningeomas também podem estar associados, porém a sua presença deve sempre levar à pesquisa de esclerose tuberosa. Funcionalmente, a doença caracteriza-se por um distúrbio ventilatório obstrutivo, de caráter progressivo, com hiperinsuflação pulmonar e diminuição da difusão de monóxido de carbono. Apesar da ausência de comprovação quanto à eficácia, o principal tratamento utilizado ainda é o anti-estrogênico e constitui-se de oofarectomia, progesterona contÃnua, tamoxifeno e análogos de GnRH. Além desse, a realização de transplantes pulmonares tem elevado para além de dez anos a sobrevida média das pacientes.<br>Lymphangioleiomyomatosis (LAM) is a rare lung disease of unkwnon etiology that frequently affects women in childbearing age. Clinically it manifests itself by and pneumothorax. Chylous pleural effusions and hemoptisis occur less frenquently. All these fenomena results from the abnormal smooth muscle proliferation in the lung parenchima. Lymph-nodes, small airways and blood vessels. More recently cytogenetic studies disclosed mutations of the TSC-2 gene in cells of renal angiomyolipoma and/or abdominal lymph nodes, pointing towards a possible origin of the hamartomatous lesions. Chest radiography may appear normal or yield reticulonodular infiltrates and signs of hyperinsuflation. At HRCT scans, multiple thin-walled cysts can be seen over the lung parenchyma. Abdominal imaging by either ultrasound or CT may show renal angiomyolipomas and retroperitoneal lymph node enlargement. Meningeomas may also be associated but their presence requires testing for tuberous sclerosis complex. Physiologically LAM is characterized by progressive airflow obstruction, air trapping and gastransfer impairment. Estrogenic suppression with either oophorectomy, deposit progestogens, tamoxifen and GnRh analogs, is still the main treatment. In addition to this therapy lung transplantations have increased patients median survival rates by more than ten years