Gestión de una comunidad profesional de aprendizaje para mejorar el desarrollo de las competencias del área de matemática en los estudiantes de la institución educativa N° 32061 - Francisco Bolognesi Cervantes - Chinchinga - San Pablo de Pillao – Huánuco

La investigación asumida por el colectivo de docentes del Nivel Primaria, en un esbozo de estudios, tiene la singular pero fundamental razón de fortalecer la práctica de la docencia, especialmente en el manejo del enfoque de las competencias de resolución de situaciones problemáticas de la Matemática y su incumbencia en los resultados de aprendizaje de los sujetos conformantes de nuestra institución educativa. Para tal efecto, las evidencias recolectadas como medio de información, cobraron su vigencia a través del monitoreo aunque escasa, pero trascendente para el caso, la interpretación de resultados internos, concursos y ECE en dicha materia. Se afirmó el manejo de todos estos elementos con la utilización de la encuesta y su respectivo cuestionario infiltrada para cada uno de los docentes, obteniendo valiosa información para el replanteo pedagógico en aula. Lo obtenido, en consideración a no ser un resultado, sino un proceso de implementación de una escuela que actúa como una Comunidad Profesional de Aprendizaje, institucionalizando una cultura con y por MAE, incorporando espacios de integración y presencia activa de los padres de familia en y para los aprendizajes de sus hijos.The research undertaken by the group of teachers of the Primary Level, in an outline of studies, has the unique but fundamental reason of strengthening the practice of teaching, especially in the handling of the approach of the competences of resolution of problematic situations of Mathematics and its incumbency in the learning results of the subjects that make up our educational institution. For this purpose, the evidence collected as a means of information, gained its validity through monitoring, although scarce, but transcendent for the case, the interpretation of internal results, contests and ECE in said matter. The management of all these elements was affirmed with the use of the survey and its respective infiltrated questionnaire for each of the teachers, obtaining valuable information for the pedagogical rethinking in the classroom. The obtained, in consideration of not being a result, but a process of implementation of a school that acts as a Professional Learning Community, institutionalizing a culture with and by MAE, incorporating spaces of integration and active presence of parents in and for their children's learning.Tesis de segunda especialida

Clonal chromosomal mosaicism and loss of chromosome Y in elderly men increase vulnerability for SARS-CoV-2

The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, COVID-19) had an estimated overall case fatality ratio of 1.38% (pre-vaccination), being 53% higher in males and increasing exponentially with age. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, we found 133 cases (1.42%) with detectable clonal mosaicism for chromosome alterations (mCA) and 226 males (5.08%) with acquired loss of chromosome Y (LOY). Individuals with clonal mosaic events (mCA and/or LOY) showed a 54% increase in the risk of COVID-19 lethality. LOY is associated with transcriptomic biomarkers of immune dysfunction, pro-coagulation activity and cardiovascular risk. Interferon-induced genes involved in the initial immune response to SARS-CoV-2 are also down-regulated in LOY. Thus, mCA and LOY underlie at least part of the sex-biased severity and mortality of COVID-19 in aging patients. Given its potential therapeutic and prognostic relevance, evaluation of clonal mosaicism should be implemented as biomarker of COVID-19 severity in elderly people. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, individuals with clonal mosaic events (clonal mosaicism for chromosome alterations and/or loss of chromosome Y) showed an increased risk of COVID-19 lethality

Gestión de una comunidad profesional de aprendizaje para mejorar el desarrollo de las competencias del área de matemática en los estudiantes de la institución educativa N° 32061 - Francisco Bolognesi Cervantes - Chinchinga - San Pablo de Pillao – Huánuco

Tesis de segunda especialidadLa investigación asumida por el colectivo de docentes del Nivel Primaria, en un esbozo de estudios, tiene la singular pero fundamental razón de fortalecer la práctica de la docencia, especialmente en el manejo del enfoque de las competencias de resolución de situaciones problemáticas de la Matemática y su incumbencia en los resultados de aprendizaje de los sujetos conformantes de nuestra institución educativa. Para tal efecto, las evidencias recolectadas como medio de información, cobraron su vigencia a través del monitoreo aunque escasa, pero trascendente para el caso, la interpretación de resultados internos, concursos y ECE en dicha materia. Se afirmó el manejo de todos estos elementos con la utilización de la encuesta y su respectivo cuestionario infiltrada para cada uno de los docentes, obteniendo valiosa información para el replanteo pedagógico en aula. Lo obtenido, en consideración a no ser un resultado, sino un proceso de implementación de una escuela que actúa como una Comunidad Profesional de Aprendizaje, institucionalizando una cultura con y por MAE, incorporando espacios de integración y presencia activa de los padres de familia en y para los aprendizajes de sus hijos

Subcutaneous anti-COVID-19 hyperimmune immunoglobulin for prevention of disease in asymptomatic individuals with SARS-CoV-2 infection: a double-blind, placebo-controlled, randomised clinical trialResearch in context

Summary: Background: Anti-COVID-19 hyperimmune immunoglobulin (hIG) can provide standardized and controlled antibody content. Data from controlled clinical trials using hIG for the prevention or treatment of COVID-19 outpatients have not been reported. We assessed the safety and efficacy of subcutaneous anti-COVID-19 hyperimmune immunoglobulin 20% (C19-IG20%) compared to placebo in preventing development of symptomatic COVID-19 in asymptomatic individuals with SARS-CoV-2 infection. Methods: We did a multicentre, randomized, double-blind, placebo-controlled trial, in asymptomatic unvaccinated adults (≥18 years of age) with confirmed SARS-CoV-2 infection within 5 days between April 28 and December 27, 2021. Participants were randomly assigned (1:1:1) to receive a blinded subcutaneous infusion of 10 mL with 1 g or 2 g of C19-IG20%, or an equivalent volume of saline as placebo. The primary endpoint was the proportion of participants who remained asymptomatic through day 14 after infusion. Secondary endpoints included the proportion of individuals who required oxygen supplementation, any medically attended visit, hospitalisation, or ICU, and viral load reduction and viral clearance in nasopharyngeal swabs. Safety was assessed as the proportion of patients with adverse events. The trial was terminated early due to a lack of potential benefit in the target population in a planned interim analysis conducted in December 2021. ClinicalTrials.gov registry: NCT04847141. Findings: 461 individuals (mean age 39.6 years [SD 12.8]) were randomized and received the intervention within a mean of 3.1 (SD 1.27) days from a positive SARS-CoV-2 test. In the prespecified modified intention-to-treat analysis that included only participants who received a subcutaneous infusion, the primary outcome occurred in 59.9% (91/152) of participants receiving 1 g C19-IG20%, 64.7% (99/153) receiving 2 g, and 63.5% (99/156) receiving placebo (difference in proportions 1 g C19-IG20% vs. placebo, −3.6%; 95% CI -14.6% to 7.3%, p = 0.53; 2 g C19-IG20% vs placebo, 1.1%; −9.6% to 11.9%, p = 0.85). None of the secondary clinical efficacy endpoints or virological endpoints were significantly different between study groups. Adverse event rate was similar between groups, and no severe or life-threatening adverse events related to investigational product infusion were reported. Interpretation: Our findings suggested that administration of subcutaneous human hyperimmune immunoglobulin C19-IG20% to asymptomatic individuals with SARS-CoV-2 infection was safe but did not prevent development of symptomatic COVID-19. Funding: Grifols