1,867 research outputs found

    Connecting places: writing about and with Portal

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    Thesis (M.A.) University of Alaska Fairbanks, 2014Shannon Carter's pedagogy of rhetorical dexterity involves students using a familiar literacy at a meta-level to make sense out of an unfamiliar one. I used her pedagogy, as well as insights from James Paul Gee and John Dewey, in designing a 213x course on writing technologies. The writing prompt for the second unit asked students to write about their inquiry into the game space and reflect on how their experiences met up with research about video games in American society in general. The unit was sequenced with the intention that students would look at their own familiar literacies, understand them on a meta-level, before inquiry into "Portal." To understand one thing in terms of another is a metaphorical, conceptual understanding. Therefore, I use George Lakoff and Mark Johnson's theories on metaphorical language to analyze student writing. The second unit project involved students navigating multiple digital contexts: Google Drive, WordPress, class discussions, and the video game "Portal." My research investigates: How did students understand "Portal"? What role did "Portal" play in identity construction in my class?Introduction -- "Bad at Video Games" -- Three Theorists and Flexibility in Learning -- My Own Digital Literacy Narrative -- Chapter 1: Making Connections -- 1.1 Rhetorical Dexterity -- 1.2 Video Games, Learning, and Literacy -- 1.3 The Course of Reflective Thought -- 1.4 Why Metaphor Theory? -- 1.5 Why Portal? -- 1.6 Course Design -- 1.7 Research Context -- 1.8 The Evolution of the Course -- Chapter 2: Thinking with Portals -- 2.1 Video games are forces (The Game Changes the Player) -- 2.2 Video games are mirrors (The Game Reflects the Player) -- 2.3 Video games are opponents (The Game is Against the Player) -- 2.4 Video games are a malleable material (The Player Changes the Game) -- 2.5 Initial Reflections -- Chapter 3: Reflections -- 3.1 Findings -- Works cited -- Selected bibliography

    Assessing Addictions in a Spiritual World: Using Confirmatory Factor Analysis and Structural Equations Modeling to Develop the Life Interests Questionnaire

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    This study uses the thoughts and writings of Evagrius of Ponticus to provide a measure useful in assessing addictions in relation to spirituality. Evagrius (1972) theorizes that there are eight tempting thoughts that can form the basis of disordered attachments, and that these deadly thoughts could lead one to a life of addictions. These thoughts formed the foundation of the Life Interests Questionnaire (LIQ). This self-report survey consists of 170 items, all of which are scored on a Likert scale (1 = strongly agree and 5 = strongly disagree). The LIQ was paired with an interest survey containing 43 items taken from previously tested measures. These questions asked about one’s religious identification, locus of control, and beliefs about the world. In a pilot study, each attachment item group was examined through confirmatory factor analysis which allowed the substructure of the questionnaire to be examined and the overall fit of the model was found to be marginally adequate (GFI 0.8889). Reliability and validity of this measure were attained primarily through construct validity and it found both a valid and reliable measure of Evagrius’s underlying theory. Future plans include correlational studies between religious identification/practices and level of disordered attachments

    Assessing the impact of the introduction of an electronic hospital discharge system on the completeness and timeliness of discharge communication: a before and after study

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    Background: Hospital discharge summaries are a key communication tool ensuring continuity of care between primary and secondary care. Incomplete or untimely communication of information increases risk of hospital readmission and associated complications. The aim of this study was to evaluate whether the introduction of a new electronic discharge system (NewEDS) was associated with improvements in the completeness and timeliness of discharge information, in Nottingham University Hospitals NHS Trust, England. Methods: A before and after longitudinal study design was used. Data were collected using the gold standard auditing tool from the Royal College of Physicians (RCP). This tool contains a checklist of 57 items grouped into seven categories, 28 of which are classified as mandatory by RCP. Percentage completeness (out of the 28 mandatory items) was considered to be the primary outcome measure. Data from 773 patients discharged directly from the acute medical unit over eight-week long time periods (four before and four after the change to the NewEDS) from August 2010 to May 2012 were extracted and evaluated. Results were summarised by effect size on completeness before and after changeover to NewEDS respectively. The primary outcome variable was represented with percentage of completeness score and a non-parametric technique was used to compare pre-NewEDS and post-NewEDS scores. Results: The changeover to the NewEDS resulted in an increased completeness of discharge summaries from 60.7% to 75.0% (p < 0.001) and the proportion of summaries created under 24 h from discharge increased significantly from 78.0% to 93.0% (p < 0.001). Furthermore, five of the seven grouped checklist categories also showed significant improvements in levels of completeness (p < 0.001), although there were reduced levels of completeness for three items (p < 0.001). Conclusion: The introduction of a NewEDS was associated with a significant improvement in the completeness and timeliness of hospital discharge communication

    Validation of the HULL Score clinical prediction rule (CPR) for unsuspected pulmonary embolism in ambulatory cancer patients

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    Background Clinical prediction rules (CPRs) developed to predict adverse outcomes of suspected pulmonary embolism (PE) and facilitate outpatient management have limitations in discriminating outcomes for ambulatory cancer patients with unsuspected PE (UPE). The HULL Score CPR uses a 5‑point scoring system incorporating performance status and self-reported new or recently evolving symptoms at UPE diagnosis. It stratifies patients into low, intermediate and high risk for proximate mortality. This study aimed to validate the HULL Score CPR in ambulatory cancer patients with UPE. Patients and methods 282 consecutive patients managed under the UPE-acute oncology service in Hull University Teaching Hospitals NHS Trust were included from January 2015 to March 2020. The primary end-point was all-cause mortality, and outcome measures were proximate mortality for the three risk categories of the HULL Score CPR. Results 30-day, 90-day and 180-day mortality rates for the whole cohort were 3.4% (n=7), 21.1% (n=43) and 39.2% (n=80), respectively. The HULL Score CPR stratified patients into low-risk (n=100, 35.5%), intermediate-risk (n=95, 33.7%) and high-risk (n=81, 28.7%) categories. Correlation of the risk categories with 30-day mortality (area under the curve (AUC) 0.717, 95% CI 0.522–0.912), 90-day mortality (AUC 0.772, 95% CI 0.707–0.838), 180-day mortality (AUC 0.751, 95% CI 0.692–0.809) and overall survival (AUC 0.749, 95% CI 0.686–0.811) was consistent with the derivation cohort. Conclusion This study validates the capacity of the HULL Score CPR to stratify proximate mortality risk in ambulatory cancer patients with UPE. The score uses immediately available clinical parameters and is easy to integrate into an acute outpatient oncology setting

    IL-33 potentiates histaminergic itch

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    BACKGROUND: Itch is a common symptom that can greatly diminish quality of life. Histamine is a potent endogenous pruritogen, and while antihistamines are often the first-line treatment for itch, in conditions like chronic spontaneous urticaria (CSU), many patients remain symptomatic while receiving maximal doses. Mechanisms that drive resistance to antihistamines are poorly defined. OBJECTIVES: Signaling of the alarmin cytokine IL-33 in sensory neurons is postulated to drive chronic itch by inducing neuronal sensitization to pruritogens. Thus, we sought to determine if IL-33 can augment histamine-induced (histaminergic) itch. METHODS: Itch behavior was assessed in response to histamine after IL-33 or saline administration. Various stimuli and conditional and global knockout mice were utilized to dissect cellular mechanisms. Multiple existing transcriptomic data sets were evaluated, including single-cell RNA sequencing of human and mouse skin, microarrays of isolated mouse mast cells at steady state and after stimulation with IL-33, and microarrays of skin biopsy samples from subjects with CSU and healthy controls. RESULTS: IL-33 amplifies histaminergic itch independent of IL-33 signaling in sensory neurons. Mast cells are the top expressors of the IL-33 receptor in both human and mouse skin. When stimulated by IL-33, mouse mast cells significantly increase IL-13 levels. Enhancement of histaminergic itch by IL-33 relies on a mast cell- and IL-13-dependent mechanism. IL-33 receptor expression is increased in lesional skin of subjects with CSU compared to healthy controls. CONCLUSIONS: Our findings suggest that IL-33 signaling may be a key driver of histaminergic itch in mast cell-associated pruritic conditions such as CSU

    RELICS: High-Resolution Constraints on the Inner Mass Distribution of the z=0.83 Merging Cluster RXJ0152.7-1357 from strong lensing

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    Strong gravitational lensing (SL) is a powerful means to map the distribution of dark matter. In this work, we perform a SL analysis of the prominent X-ray cluster RXJ0152.7-1357 (z=0.83, also known as CL 0152.7-1357) in \textit{Hubble Space Telescope} images, taken in the framework of the Reionization Lensing Cluster Survey (RELICS). On top of a previously known z=3.93z=3.93 galaxy multiply imaged by RXJ0152.7-1357, for which we identify an additional multiple image, guided by a light-traces-mass approach we identify seven new sets of multiply imaged background sources lensed by this cluster, spanning the redshift range [1.79-3.93]. A total of 25 multiple images are seen over a small area of ~0.4 arcmin2arcmin^2, allowing us to put relatively high-resolution constraints on the inner matter distribution. Although modestly massive, the high degree of substructure together with its very elongated shape make RXJ0152.7-1357 a very efficient lens for its size. This cluster also comprises the third-largest sample of z~6-7 candidates in the RELICS survey. Finally, we present a comparison of our resulting mass distribution and magnification estimates with those from a Lenstool model. These models are made publicly available through the MAST archive.Comment: 15 Pages, 7 Figures, 4 Tables Accepted for publication in Ap
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