2,317 research outputs found
Study of rapitalam influence on oxotremorine-induced tremor
Of the article is to study Rapitalam influence on the oxotremorine-induced tremor in rat
Assessment of the DNA damage level in peripheral blood leukocytes of mice treated orally with Rapitalam in acute and therapeutic doses
Centre there was performed experimental research, which carried out the identification and quantitative assessment of alkali-labile sites and DNA strand breaks in leukocytes of peripheral blood of male mice treated with Rapitalam. The method is based on the assessment of the integrity of DNA in leukocytes of the whole blood of animals. Rapitalam was administered to animals orally according to 2 schemes: a single acute dose (413 mg/kg, which corresponds to 1/5 LD50 dose) and once daily in a therapeutic dose (3 mg/kg) for 4 day
Novel mGluR4 agonist Rapitalam ameliorates motor dysfunction in mice with tau-associated neurodegeneration
Tau protein is classically involved in the pathogenesis of a neurodegenerative processes, such as Parkinsonβs disease. This study was aimed at testing the novel mGluR4 selective agonist using it in transgenic mice with tau-associated neurodegeneratio
The definition of specific antiparkinsonian effects of Rapitalam
Previously, we identified a metabotropic glutamate receptor 4 (mGluR4) as a potential target for drugs and predicted that activation of mGluR4 could provide a palliative advantage in the treatment of Parkinson's disease. Determine the mechanism of action of Rapitalam in vitro on a cell culture with mGluR4 over expression. The HEK293T cell line expressing human mGluR4 was used in the wor
Pharmacokinetic studies of new antiparkinsonian drug Rapitalam
The aim of this study was to investigate the pharmacokinetic parameters of the mGluR4 receptor blocker Rapitalam on rabbits. There was developed the method of the quantitative determination of Rapitalam in the blood plasma of rabbits using high performance liquid chromatography with tandem mass spectrometric detection. The study was performed on 12 rabbits (males, weighing between 3,300 to 3,500 g). In intragastric dosing of the substance was administered using a gastric tube in the form of suspension in water 0.9 mg/ml, 9 mg/ml, and 90 mg/ml at a dose of 0.3 mg/kg, 3 mg/kg and 30 mg/kg. The main pharmacokinetic parameters of the substance was established on rabbits that allow you to optimize the future use of it's as a potential drug for the treatment of Parkinson's diseas
The possibility of administration of glutamate receptors antagonists in the treatment of parkinson's disease
Parkinson's disease is the slow-progressing chronic neurodegenerative disease. Modern medicine has not yet found methods of curing disease, however, the existing methods of conservative and surgical treatment significantly improve the patientβs quality of life and slow the progression of the diseas
Chemical analysis of bioactive substances in seven siberian Saussurea species
Main groups of biologically active substances of seven siberian Saussurea species (S. controversa DC., S. latifolia Ledeb., S. parviflora (Poir.) DC., S. frolowii Ledeb, S. amara (L.) DC., S. salicifolia (L.) DC. and S. daurica Adams) have been studied using paper, thin-layer, performance liquid chromatography, IR spectroscopy, spectrophotometry and mass spectrometry with inductively coupled plasma. Siberian Saussurea species have a rich elemental composition and contain a variety of phenolic compounds, amino acids, polysaccharides. The majority of polysaccharides are accumulated by S. controversa, S. salicifolia and S. frolowii. These plants contain a significant amount of calcium that may be a species characteristic. All plants contain quercetin and its glycosides, in some species luteolin, kaempferol, glycosides of apigenin and myricetin were revealed. Phenolic acids with predominant content of caffeic, chlorogenic and cinnamic acids were found in all the species. The maximum amount of phenolic acids and flavonoids was determined in the grass of S. latifolia, S. controversa and S. daurica. Characteristic absorption bands of lactone carbonyl of sesquiterpenoids in IR spectrum found in S. latifolia, S. controversa, S. daurica, S. amara and S. salicifolia. HPLC / UV analysis showed that peaks with absorption maxima of 242-246β
nm due to the presence of Ξ±,Ξ²-unsaturated ketone group in the structure of ecdysteroids were found in S. salicifolia, S. controversa, S. daurica and S. latifolia
The Assessment of the Level of Pollution of Slime Pits with Heavy Metals
In drilling and running oil and gas wells the great amount of toxic waste is formed and in the surface of the lithosphere and hydrosphere the great amount of different chemical elements and compounds access, they are needed to be isolated from the environment. The most useful way of isolation is their utilization in the slime pits on the wells territory. Heavy metals are dangerous waste in the drilling slime; they accumulate in soil and under some conditions they in form water-soluble parts and migrate in to the soil. The aim of this paper is to organize the chemical and analytical research of the amount of heavy metals in the drilling slime, and research the mechanism of their spreading on different depth and square in the slime pits typical for the oil site placed in KHANTY-Ugra
Β«ΠΠ½ΡΠΈΠΏΠ»Π°Π³ΠΈΠ°Ρ.Π ΠΠΒ» - ΡΠΈΡΡΠ΅ΠΌΠ° Π΄Π»Ρ Π²Π΅ΡΠΈΡΠΈΠΊΠ°ΡΠΈΠΈ Π°Π²ΡΠΎΡΡΠΊΠΈΡ ΡΠ΅ΠΊΡΡΠΎΠ²
For handling the problem of falsification in science and combating the intellectual plagiarism there is required verification system of document texts originality. The Β«Antiplagiat.RSLΒ» system can serve as an example of such a system, for it is an independent expertise tool, performing comparative semantic and stylistic assessment of textual matching content. Expert Certificate on the Originality of Text, issued by the Russian State Library, is an official document, containing information on presence/absence of plagiarism in scientific texts.ΠΠ»Ρ ΡΠ΅ΡΠ΅Π½ΠΈΡ ΠΏΡΠΎΠ±Π»Π΅ΠΌΡ ΡΠ°Π»ΡΡΠΈΡΠΈΠΊΠ°ΡΠΈΠΉ Π² Π½Π°ΡΠΊΠ΅ ΠΈ Π±ΠΎΡΡΠ±Ρ Ρ ΠΏΠ»Π°Π³ΠΈΠ°ΡΠΎΠΌ Π½Π΅ΠΎΠ±Ρ
ΠΎΠ΄ΠΈΠΌΠ° ΠΎΡΠ΅Π½ΠΊΠ° ΠΎΡΠΈΠ³ΠΈΠ½Π°Π»ΡΠ½ΠΎΡΡΠΈ ΡΠ΅ΠΊΡΡΠΎΠ² Π΄ΠΎΠΊΡΠΌΠ΅Π½ΡΠΎΠ². Π Π΅Π°Π»ΠΈΠ·ΠΎΠ²Π°ΡΡ Π΅Π΅ ΠΌΠΎΠΆΠ½ΠΎ Ρ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ΠΈΠ΅ΠΌ ΡΠΈΡΡΠ΅ΠΌΡ Β«ΠΠ½ΡΠΈΠΏΠ»Π°Π³ΠΈΠ°Ρ.Π ΠΠΒ», ΠΊΠΎΡΠΎΡΠ°Ρ ΡΠ²Π»ΡΠ΅ΡΡΡ ΠΈΠ½ΡΡΡΡΠΌΠ΅Π½ΡΠΎΠΌ Π½Π΅Π·Π°Π²ΠΈΡΠΈΠΌΠΎΠ³ΠΎ ΡΠΊΡΠΏΠ΅ΡΡΠ°, ΠΎΡΡΡΠ΅ΡΡΠ²Π»ΡΡΡΠ΅Π³ΠΎ ΡΡΠ°Π²Π½ΠΈΡΠ΅Π»ΡΠ½ΡΡ ΡΠΌΡΡΠ»ΠΎΠ²ΡΡ ΠΈ ΡΡΠΈΠ»ΠΈΡΡΠΈΡΠ΅ΡΠΊΡΡ ΠΎΡΠ΅Π½ΠΊΡ Π·Π°ΠΈΠΌΡΡΠ²ΠΎΠ²Π°Π½ΠΈΠΉ. ΠΠ°ΠΊΠ»ΡΡΠ΅Π½ΠΈΠ΅ ΠΎΠ± ΠΎΡΠΈΠ³ΠΈΠ½Π°Π»ΡΠ½ΠΎΡΡΠΈ, Π²ΡΠ΄Π°Π½Π½ΠΎΠ΅ Π ΠΎΡΡΠΈΠΉΡΠΊΠΎΠΉ Π³ΠΎΡΡΠ΄Π°ΡΡΡΠ²Π΅Π½Π½ΠΎΠΉ Π±ΠΈΠ±Π»ΠΈΠΎΡΠ΅ΠΊΠΎΠΉ, ΡΠ²Π»ΡΠ΅ΡΡΡ ΠΎΡΠΈΡΠΈΠ°Π»ΡΠ½ΡΠΌ Π΄ΠΎΠΊΡΠΌΠ΅Π½ΡΠΎΠΌ, ΠΈΠ½ΡΠΎΡΠΌΠΈΡΡΡΡΠΈΠΌ ΠΎ Π½Π°Π»ΠΈΡΠΈΠΈ Π½Π΅ΠΊΠΎΡΡΠ΅ΠΊΡΠ½ΡΡ
Π·Π°ΠΈΠΌΡΡΠ²ΠΎΠ²Π°Π½ΠΈΠΉ (ΠΏΠ»Π°Π³ΠΈΠ°ΡΠ°) Π² Π½Π°ΡΡΠ½ΡΡ
ΡΠ΅ΠΊΡΡΠ°Ρ
The application of lean technologies to optimize oncological screening in the periodic health examination of adult population groups
Background. Improving organizational technologies for early detection of cancer using targeted programs for large-scale cancer screening is a priority task of primary health care.The aim: to assess the potential of lean technologies to optimize cancer screening during periodic health examination of the adult population.Materials and methods. To develop an optimal organizational and functional model of cancer screening, a working group was created; information about the current state of the process was collected.Results. A comprehensive analysis of the state of the process revealed the following problems: violation of the algorithms of oncological screening at stage 1 of periodic health examination (13.8 %); cases of non-completion of stage 2 of periodic health examination by patients with suspected colon cancer (20.4 %); queues for endoscopic examinations (14 days) and, as a consequence, not a quick visit to the oncologist of the primary oncology department (17β18 days). After optimization of the periodic health examination: there is no queue for endoscopy for patients with suspected oncopathology; accelerated access of patients with suspected oncopathology to the oncologist of the primary oncology department (from 17β18 to 5 days; p < 0.01). Increased awareness of patients about the rules for preparing for endoscopic examination and a reminder of the date and time of the upcoming endoscopy, there was an increase in the number of patients who completed stage 2 of health examination to exclude/confirm oncopathology (from 79.6 to 90 %; p < 0.05). The frequency of violations by doctors of the oncological screening algorithm decreased from 13.8 to 2.3 % (p < 0.01).Conclusion. The use of lean manufacturing marketing strategies in primary health care has helped to identify, eliminate and control the causes of problems during the first and second stages of clinical examination of patients with suspected oncopathology
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