Dichlorido[1-(2-chloro­eth­yl)-3-(pyridin-4-ylmethyl-κN)urea](η6-hexa­methyl­benzene)­ruthenium(II) chloro­form monosolvate

The RuII atom in the title compound, [RuCl2(C12H18)(C9H12ClN3O)]·CHCl3, exhibits a typical piano-stool coordination, defined by a hexa­methyl­benzene ligand, two chloride ligands and a pyridyl­urea ligand coordinated through the pyridine N atom. In the crystal, a dimeric structure is observed due to two strong N—H⋯Cl inter­actions between the NH groups of urea and the two chloride ligands of neighbouring mol­ecules. In addition, the C=O group of the urea moiety inter­acts with the solvent mol­ecule through weak C—H⋯O interactions

Sawhorse-type diruthenium tetracarbonyl complexes containing porphyrin-derived ligands as highly selective photosensitizers for female reproductive cancer cells

Diruthenium tetracarbonyl complexes of the type [Ru2(CO)4(μ2-η2-O2CR)2L2] containing a Ru-Ru backbone with four equatorial carbonyl ligands, two carboxylato bridges, and two axial two-electron ligands in a sawhorse-like geometry have been synthesized with porphyrin-derived substituents in the axial ligands [1: R is CH3, L is 5-(4-pyridyl)-10,15,20-triphenyl-21,23H-porphyrin], in the bridging carboxylato ligands [2: RCO2H is 5-(4-carboxyphenyl)-10,15,20-triphenyl-21,23H-porphyrin, L is PPh3; 3: RCO2H is 5-(4-carboxyphenyl)-10,15,20-triphenyl-21,23H-porphyrin, L is 1,3,5-triaza-7-phosphatricyclo[3.3.1.1]decane], or in both positions [4: RCO2H is 5-(4-carboxyphenyl)-10,15,20-triphenyl-21,23H-porphyrin, L is 5-(4-pyridyl)-10,15,20-triphenyl-21,23H-porphyrin]. Compounds 1-3 were assessed on different types of human cancer cells and normal cells. Their uptake by cells was quantified by fluorescence and checked by fluorescence microscopy. These compounds were taken up by human HeLa cervix and A2780 and Ovcar ovarian carcinoma cells but not by normal cells and other cancer cell lines (A549 pulmonary, Me300 melanoma, PC3 and LnCap prostate, KB head and neck, MDAMB231 and MCF7 breast, or HT29 colon cancer cells). The compounds demonstrated no cytotoxicity in the absence of laser irradiation but exhibited good phototoxicities in HeLa and A2780 cells when exposed to laser light at 652nm, displaying an LD50 between 1.5 and 6.5J/cm2 in these two cell lines and more than 15J/cm2 for the others. Thus, these types of porphyric compound present specificity for cancer cell lines of the female reproductive system and not for normal cells; thus being promising new organometallic photosensitizer

[6-(Hydroxymethyl)pyridin-2-yl]methyl ferrocene-1-carboxylate

The crystal structure of the title ferrocene derivative, [Fe(C5H5)(C13H12NO3)], shows strong intermolecular O-H...N hydrogen bonds between the alcohol function and the pyridine group of a neighbouring molecule, while the pyridine function forms another hydrogen bond with the alcohol function of another neighbouring molecule, resulting in the formation of chains along the a-axis direction