Compte-rendu de la journée d’étude « Qualité de vie et cohésion au travail »

Les élèves conservatrices et conservateurs promus DCB30 proposent un retour sur la journée d’étude consacrée à la qualité de vie et cohésion au travail qu’ils ont organisée le 21 mai 2021. Cette journée s’est déclinée autour de deux conférences introductives sur le thème de la qualité de vie au travail, des ateliers pour permettre à de futurs cadres de réfléchir et de mettre en place des actions relatives à ces thèmes et enfin des retours d’expériences

Un instrument de recherche pour le fonds Jean Porcher (1892-1966)

Le monde des bibliothèques fut marqué en 1963 par le départ à la retraite de Jean Porcher (1892-1966) ((Voir : « Jean Porcher », Wikipédia, l'encyclopédie libre, 12 mai 2022. Disponible sur Internet, url : .)) dont la carrière se déroula à la Bibliothèque nationale de 1923 à 1963 avec en particulier la direction du Département des manuscrits de 1945 à 1963. Jean Porcher (1892-1966) Nicole Delamarre - Porcher, CC BY-SA 4.0 https://creativecommons.org/licenses/by-sa/4.0, via Wikimedia Common...</http

Fisetin disposition and metabolism in mice: Identification of geraldol as an active metabolite.: Fisetin disposition and metabolism in mice

International audienceAlthough the natural flavonoid fisetin (3,3',4',7-tetrahydroxyflavone) has been recently identified as an anticancer agent with antiangiogenic properties in mice, its in vivo pharmacokinetics and metabolism are presently not characterized. Our purpose was to determine the pharmacokinetics and metabolism of fisetin in mice and determine the biological activity of a detected fisetin metabolite. After fisetin administration of an efficacious dose of 223 mg/kg i.p. in mice, the maximum fisetin concentration reached 2.5 μg/ml at 15 min and the plasma concentration declined biphasically with a rapid half-life of 0.09 h and a terminal half-life of 3.1h. Three metabolites were detected, one of which was a glucuronide of fisetin (M1), whereas another glucuronide (M2) was a glucuronide of a previously unknown fisetin metabolite (M3). HPLC-MS/MS analysis indicated that M3 was a methoxylated metabolite of fisetin (MW=300 Da). The UV spectrum of M3 was identical to that of fisetin and standard 3,4',7-trihydroxy-3'-methoxyflavone (geraldol). In addition, because M3 co-eluted with standard geraldol in 4 different chromatographic ternary gradient conditions, M3 was therefore assigned to geraldol. Of interest, this metabolite was shown to achieve higher concentrations than fisetin in Lewis lung tumors. We also compared the cytotoxic and antiangiogenic activities of fisetin and geraldol in vitro and it was found that the latter was more cytotoxic than the parent compound toward tumor cells, and that it could also inhibit endothelial cells migration and proliferation. In conclusion, these results suggest that fisetin metabolism plays an important role in its in vivo anticancer activities