Planar Detonation Wave Initiation in Large-Aspect-Ratio Channels

In this study, two initiator designs are presented that are able to form planar detonations with low input energy in large-aspect-ratio channels over distances corresponding to only a few channel heights. The initiators use a single spark and an array of small channels to shape the detonation wave. The first design, referred to as the static initiator, is simple to construct as it consists of straight channels which connect at right angles. However, it is only able to create planar waves using mixtures that can reliably detonate in its small-width channels. An improved design, referred to as the dynamic initiator, is capable of detonating insensitive mixtures using an oxyacetylene gas slug injected into the initiator shortly before ignition, but is more complex to construct. The two versions are presented next, including an overview of their design and operation. Design drawings of each initiator are available elsewhere [7]. Finally, photographs and pressure traces of the resulting planar waves generated by each device are shown

Analytical Model for the Impulse of Single-Cycle Pulse Detonation Tube

An analytical model for the impulse of a single-cycle pulse detonation tube has been developed and validated against experimental data. The model is based on the pressure history at the thrust surface of the detonation tube. The pressure history is modeled by a constant pressure portion, followed by a decay due to gas expansion out of the tube. The duration and amplitude of the constant pressure portion is determined by analyzing the gasdynamics of the self-similar flow behind a steadily moving detonation wave within the tube. The gas expansion process is modeled using dimensional analysis and empirical observations. The model predictions are validated against direct experimental measurements in terms of impulse per unit volume, specific impulse, and thrust. Comparisons are given with estimates of the specific impulse based on numerical simulations. Impulse per unit volume and specific impulse calculations are carried out for a wide range of fuel–oxygen–nitrogen mixtures (including aviation fuels) of varying initial pressure, equivalence ratio, and nitrogen dilution. The effect of the initial temperature is also investigated. The trends observed are explained using a simple scaling analysis showing the dependency of the impulse on initial conditions and energy release in the mixture

Chemical structure matching using correlation matrix memories

This paper describes the application of the Relaxation By Elimination (RBE) method to matching the 3D structure of molecules in chemical databases within the frame work of binary correlation matrix memories. The paper illustrates that, when combined with distributed representations, the method maps well onto these networks, allowing high performance implementation in parallel systems. It outlines the motivation, the neural architecture, the RBE method and presents some results of matching small molecules against a database of 100,000 models

On the Sensitivity of Massive Star Nucleosynthesis and Evolution to Solar Abundances and to Uncertainties in Helium Burning Reaction Rates

We explore the dependence of pre-supernova evolution and supernova nucleosynthesis yields on the uncertainties in helium burning reaction rates. Using the revised solar abundances of Lodders (2003) for the initial stellar composition, instead of those of Anders & Grevesse (1989), changes the supernova yields and limits the constraints that those yields place on the 12C(a,g)16O reaction rate. The production factors of medium-weight elements (A = 16-40) were found to be in reasonable agreement with observed solar ratios within the current experimental uncertainties in the triple alpha reaction rate. Simultaneous variations by the same amount in both reaction rates or in either of them separately, however, can induce significant changes in the central 12C abundance at core carbon ignition and in the mass of the supernova remnant. It therefore remains important to have experimental determinations of the helium burning rates so that their ratio and absolute values are known with an accuracy of 10% or better.Comment: Accepted for publication by the Astrophysical Journa

Unraveling How Candida albicans Forms Sexual Biofilms.

Biofilms, structured and densely packed communities of microbial cells attached to surfaces, are considered to be the natural growth state for a vast majority of microorganisms. The ability to form biofilms is an important virulence factor for most pathogens, including the opportunistic human fungal pathogen Candida albicans. C. albicans is one of the most prevalent fungal species of the human microbiota that asymptomatically colonizes healthy individuals. However, C. albicans can also cause severe and life-threatening infections when host conditions permit (e.g., through alterations in the host immune system, pH, and resident microbiota). Like many other pathogens, this ability to cause infections depends, in part, on the ability to form biofilms. Once formed, C. albicans biofilms are often resistant to antifungal agents and the host immune response, and can act as reservoirs to maintain persistent infections as well as to seed new infections in a host. The majority of C. albicans clinical isolates are heterozygous (a/α) at the mating type-like (MTL) locus, which defines Candida mating types, and are capable of forming robust biofilms when cultured in vitro. These "conventional" biofilms, formed by MTL-heterozygous (a/α) cells, have been the primary focus of C. albicans biofilm research to date. Recent work in the field, however, has uncovered novel mechanisms through which biofilms are generated by C. albicans cells that are homozygous or hemizygous (a/a, a/Δ, α/α, or α/Δ) at the MTL locus. In these studies, the addition of pheromones of the opposite mating type can induce the formation of specialized "sexual" biofilms, either through the addition of synthetic peptide pheromones to the culture, or in response to co-culturing of cells of the opposite mating types. Although sexual biofilms are generally less robust than conventional biofilms, they could serve as a protective niche to support genetic exchange between mating-competent cells, and thus may represent an adaptive mechanism to increase population diversity in dynamic environments. Although conventional and sexual biofilms appear functionally distinct, both types of biofilms are structurally similar, containing yeast, pseudohyphal, and hyphal cells surrounded by an extracellular matrix. Despite their structural similarities, conventional and sexual biofilms appear to be governed by distinct transcriptional networks and signaling pathways, suggesting that they may be adapted for, and responsive to, distinct environmental conditions. Here we review sexual biofilms and compare and contrast them to conventional biofilms of C. albicans

Improved AURA k-Nearest Neighbour approach

The k-Nearest Neighbour (kNN) approach is a widely-used technique for pattern classification. Ranked distance measurements to a known sample set determine the classification of unknown samples. Though effective, kNN, like most classification methods does not scale well with increased sample size. This is due to their being a relationship between the unknown query and every other sample in the data space. In order to make this operation scalable, we apply AURA to the kNN problem. AURA is a highly-scalable associative-memory based binary neural-network intended for high-speed approximate search and match operations on large unstructured datasets. Previous work has seen AURA methods applied to this problem as a scalable, but approximate kNN classifier. This paper continues this work by using AURA in conjunction with kernel-based input vectors, in order to create a fast scalable kNN classifier, whilst improving recall accuracy to levels similar to standard kNN implementations

Exhaust of Underexpanded Jets from Finite Reservoirs

The response of an underexpanded jet to a depleting finite reservoir is examined with experiments and simulations. An open-ended shock-tube facility with a variable reservoir length is used to obtain images of nitrogen- and helium-jet structures at successive instances during the blowdown from initial pressure ratios of up to 250. The reservoir and ambient pressures are simultaneously measured to obtain the instantaneous pressure ratio. We estimate the time scales for jet formation and reservoir depletion as a function of the specific heat ratio of the gas and the initial pressure ratio. The jet structure formation time scale is found to become approximately independent of the pressure ratio for ratios greater than 50. In the present work, no evidence of time dependence in the Mach disk shock location is observed for rates of pressure decrease associated with isentropic blowdown of a finite reservoir while the pressure ratio is greater than 15. The shock location in the finite-reservoir jet can be calculated from an existing empirical fit to infinite-reservoir jet data evaluated at the instantaneous reservoir pressure. For pressure ratios below 15, however, the present data deviate from a compilation of data for infinite-reservoir jets. A new fit is obtained to data in the lower-pressure regime. The self-similarity of the jet structure is quantified, and departure from similarity is noted to begin at pressure ratios lower than about 15, approximately the same ratio that limits existing empirical fits

Design Considerations and Structural Analysis of the Narrow Channel Facility

The narrow channel (NC) facility design is based on the GALCIT Detonation Tube (GDT) test section design of Mike Kaneshige [3]. The main differences are 1) the design of the longitudinal bolted joint was simplified and 2) the keys for the flanges are not designed to assist with shear loading. The GDT side windows and PLIF window may be used in the NC facility. 304 SS was chosen for its excellent corrosion resistance. The yield strength is 275 MPa. 304 SS is non-magnetic and is therefore more difficult to grind on a table with magnetic locking. All four plates were blanchard ground (using mechanical locking to the table through some of the bolt holes which were drilled before grinding) by a subcontractor for Hales. All pieces were machined by Hales except the initiator, window sealing plates, end flange sealing plates which were made by the Aeroshop. Hales also supplied the material and checked the assembly of the pieces. After delivery from Hales, the internal surfaces of the four channel plates were hand-sanded to a mirror finish