Influence of Adjuvant Therapy in Cancer Survivors on Endothelial Function and Skeletal Muscle Deoxygenation

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The rate of change for tissue oxygenation index (TOI; Panel A), deoxygenated hemoglobin ([HHb]; Panel B), and total hemoglobin ([Hb]_total; Panel C) as a function of oxygen uptake (V˙O2).

<p>Note that the absolute change in TOI and [HHb] as a function of the increase <math><mrow><msub><mrow>V<mo>˙</mo>O</mrow><mn>2</mn></msub></mrow></math> during exercise were significantly less in cancer survivors compared to controls. Values are mean ± SE.</p

Near-infrared spectroscopy (NIRS)-obtained muscle oxygenation data at baseline, 50 W, and the ventilatory threshold (VT).

<p>Tissue oxygenation index (TOI; Panel A) in the cancer survivors remained at baseline levels throughout the test compared to the progressive decrease observed in controls. Deoxygenated hemoglobin ([HHb]; Panel B) was significantly lower in cancer survivors compared to controls at VT. Total hemoglobin ([Hb]_total; Panel C) at VT was significantly decreased in the cancer survivors compared to controls. Values are mean ± SE; † P<0.05 significantly different compared to baseline. * P<0.05 significantly different compared to controls.</p

Endothelium-dependent, flow-mediated, brachial artery dilation (FMD) in control and cancer survivors (CS).

<p>FMD values are shown normalized for the magnitude of the hyperaemic shear stimulus (i.e. % change in diameter divided by the AUC_SR).</p