Deterministic Separation of Cancer Cells from Blood at 10 mL/min

Circulating tumor cells (CTCs) and circulating clusters of cancer and stromal cells have been identified in the blood of patients with malignant cancer and can be used as a diagnostic for disease severity, assess the efficacy of different treatment strategies and possibly determine the eventual location of metastatic invasions for possible treatment. There is thus a critical need to isolate, propagate and characterize viable CTCs and clusters. Here, we present a microfluidic device for mL/min flow rate, continuous-flow capture of viable CTCs from blood using deterministic lateral displacement arrays. We show here that a deterministic bump array can be designed such that it will isolate with efficiency greater than 85% CTCs over a large range in sizes from millimeter volume clinical blood samples in minutes, with no effect on cell vitality so that further culturing and analysis of the cells can be carried out

Copper(I) Chloride Carbonyl Polymers

Addition of bridging diamine ligands to methanolic solutions of CuCl under a CO purge produces the polymeric complexes [(CuCl)2(CO)2(biL)] (biL = diazabicyclo[2.2.2]octane (DABCO), piperazine (Pip), N,N‘-dimethylpiperazine (DMP)). X-ray crystal structures of the three complexes reveal rhombic OC−Cu(μ-Cl)2Cu−CO bridged by biL. Unsaturated bridging ligands fail to produce carbonyl-bearing products

Recovery-informed Theory: Situating the Subjective in the Science of Substance Use Disorder Recovery

As recovery from substance use disorder becomes more than a mere quantifiable outcome, there exists a need to discuss and propose the underlying theoretical constructs that ultimately describe and identify the science of recovery. In this abstract undertaking, we propose an initial formulation of a grand theory of recovery science, built upon the seminal theories of recovery capital, recovery-oriented systems of care, and socioecological theory. This grand theory - labeled recovery-informed theory (RIT) - states that successful long-term recovery is self-evident and is a fundamentally emancipatory set of processes. This paper will discuss, analyze, and explore this theory as it is situated within the larger substance use, misuse, and disorder contexts. The uses, implications, and benefits of RIT as an organizing point of inquiry for recovery science are also discussed. By promoting the role of subjective recovery experience in the formulation of the study of recovery, it may be possible to summon new ideas, metrics, and strategies that can directly address substance use disorders in society. Adopting a recovery-informed understanding as follows from this grand theory may allow individual recovery and wellness trajectories to be explored, adapted, and modified to exemplify person-centered and individualized recovery strategies

Using Digital Technology to Innovate Product Meaning: Case studies in Electric Vehicles

Human Computer Interaction scholars have predominantly adopted a “user-centered” approach to study changes in product functions and aesthetics. Relatively few, however, have explored how designers radically innovate by proposing new product meaning with digital technology. Product meaning refers to an impression, conveyed collectively by a defining set of functional and/or aesthetic qualities of a product, that cause it to be perceived as a particular kind of product. We draw on design and innovation theories and use comparative case studies of electric vehicle to articulate three mechanisms by which designers propose “what would be desirable” for users: designers use digital technology (1) as a part of the product, in the process of delivering product, and in new contexts to propose innovative meaning (2) to collect user feedback, and (3) to selectively take user feedback to re-propose innovative meaning. The paper extends previous user-centered IS literature with a designer-centered approach

A “Novel” Approach to the Design of an IS Management Course

We report on the design and implementation of an unusual course in Information Systems (IS) management built around an extended case series: a fictitious but reality-based story about the trials and tribulations of a newly appointed but not-technically-trained Chief Information Officer (CIO) in his first year on the job. Together the cases constitute a true-to-life “novel” about IS management (published, in fact, as a novel, as well as individual cases). Four principles guided development of the series and its associated pedagogy: 1) Emphasis on integrative, soft-skill, and business-oriented aspects of IS, independent of underlying technologies; 2) Student derivation and ongoing refinement of cumulative theoretical frameworks arrived at via in-class discussion; 3) Identification of a set of core issues vital to practice that collectively approximate IS management as a business discipline; and 4) Design for student engagement, in particular by basing the case “story” on the monomyth, a literary pattern common to important narratives around the world. A supporting website facilitates sharing of teaching materials and experiences by faculty using the case series. We report results from using this curriculum with undergraduate and graduate students in two universities in different countries, and with executives at a multinational corporation and in an executive program at Harvard Business School. Our results suggest that a “novel-based” approach holds considerable promise for use at undergraduate, graduate, and executive levels, and that it might have advantages in addressing the so-called “enrollment crisis” in IS education, especially with the generation of “digital natives” who have come of age in an environment crowded with engaging approaches to communication and entertainment that compete for their attention

Where do we come from, where are we now, and where are we going? The Evolution of Collegiate Recovery Science

Attendees will be provided with a brief history/timeline of collegiate recovery as a field, through the lens of research (with a focus on the explosive growth in knowledge in the last decade). This initial presentation will be followed by a synopsis of the current state of collegiate recovery science, focusing on recent studies in the field (CRP alumni survey; meta-reviews; and any large impact studies published in the last year up to month of the conference). The session will end with a presentation on the directions for the future, making clear calls that not only does the research need to continue and in what suggested ways, but also serving to inspire students to engage in the process as they are our best hope to continue the work in innovative ways we haven't thought of. The current landscape of collegiate recovery research and recovery science overall. Additionally, attendees will be able to describe future directions for this type of inquiry. &nbsp