Experiences and Perceptions of Black Men Who Have Sex with Men About Acquiring HIV: A Qualitative Narrative Perspective.

In the United States, Black men who have sex with men (MSM), between the ages of 18 and 34 years, have the highest rates of new HIV infections. The prevalence of HIV in this population is three to four times higher than their White MSM counterparts. Twelve Black MSM from the Bay Area, nine with HIV and three without HIV, were interviewed regarding their experiences and perceived risks of acquiring HIV. Narrative analysis revealed these themes: (a) tested regularly for HIV, (b) HIV knowledge varied before arriving in San Francisco, (c) condom use typically nonexistent when under the influence of alcohol and other drugs, (d) inability to negotiate sex and condom usage, and (e) sense of anticipation, resignation, and acceptance about acquiring HIV. Implications of this study highlight the need for Black MSM to have earlier HIV prevention education, including condom negotiation skills, particularly when under the influence of drugs and/or alcohol

Leading, Energizing, and Developing Staff Through Times of Change

The nature of library work is changing. New technology, user preferences, tighter budgets, and new expectations have meant that libraries have altered and adapted the way they provide resources and services. While these changes have brought many benefits to library users, innovations in how libraries provide resources and services often have long-term implications on the skills needed from librarians and staff. Now more than ever, it\u27s important to communicate to staff about the future of their work and their roles in the library, and to provide them with the development and training they need to transition into new roles. Where do you see yourself in the next five years? is no longer applicable to just those looking to move up in the profession, but also to those individuals who wish to grow within in their current position. Takeaways: 1) Participants will be able to identify the challenges managers face when communicating with staff about the future of their work and their role in the library. 2) Participants will be able to describe the methods for conveying vision and change to staff. 3) Participants will be able to identify resources they can use to help staff transition to new roles in the library

Stroke Caregiver Outcomes from the Telephone Assessment and Skill-Building Kit (TASK)

Purpose: Stroke caregivers often express the need for information about stroke and assistance with stroke-related care in the early discharge period. The Telephone Assessment and Skill-Building Kit (TASK) is an 8-week program that addresses caregiver needs. This study explored the efficacy of the TASK program in improving stroke caregiver outcomes. Method: Guided by a conceptual model, 6 outcomes (optimism, task difficulty, threat appraisal, depressive symptoms, life changes, general health perceptions) were measured in 40 caregivers randomized to the TASK (n = 21) or an attention control group (n = 19). Data were analyzed using analysis of covariance (ANCOVA), controlling for baseline scores and minutes spent with the nurse. Results: Significant increases in optimism at 4 weeks, 8 weeks, and 12 weeks were found, with medium effect sizes for the TASK group relative to the control group (p < .05). Significant improvements in task difficulty at 4 weeks, and threat appraisal at both 8 weeks and 12 weeks were also found (p < .05). Conclusion: Caregivers receiving the TASK intervention improved in optimism, task difficulty, and threat appraisal. Further testing of an enhanced version of the TASK program is warranted, with attention directed toward more distal stroke caregiver outcomes

Content Validity and Satisfaction With a Stroke Caregiver Intervention Program

Background and Purpose Establishing evidence of content validity and satisfaction is an integral part of intervention research. The purpose of this article is to describe content validity and satisfaction relative to the Telephone Assessment and Skill-Building Kit (TASK), an 8-week follow-up program based on individualized assessment of stroke caregiver needs. Design and Methods The TASK intervention enables caregivers to develop skills based on assessment of their own needs. During the development of the TASK program, 10 experts rated the validity of the TASK intervention components for accuracy, feasibility, acceptability, and problem relevance. After incorporating feedback from the experts, a randomized controlled clinical trial was instituted using a convenience sample of 40 stroke caregivers to determine satisfaction (usefulness, case of use, and acceptability) with the TASK intervention (n=21) compared with an attention control group (n=19). Data collection occurred between March 2005 and June 2006. Data were analyzed using descriptive statistics, independent sample t tests, and content analysis. Findings Expert ratings on a 1 to 5 scale, with 5 being strongly agree, provided evidence of content validity (accuracy 4.71, feasibility 4.46, acceptability 4.40, problem relevance 4.67). Caregivers in the TASK group scored significantly higher than the attention control group on all satisfaction measures (usefulness p=.02; ease of use p=.02; acceptability p=.05). Qualitative comments from caregivers provided further evidence of satisfaction. Conclusions Evidence of content validity and user satisfaction for the TASK intervention relative to an attention control group was found. Clinical Relevance The TASK program may be a viable telephone-based program that can be implemented by nurses to support family caregivers during the first few months after stroke survivors are discharged home

Coastal ocean processes inner-shelf study : coastal and moored physical oceanographic measurements

To improve our understanding of the physical and biological processes influencing plantonic larval distributions over the inner shelf, an interdisciplinary field program funded by the National Science Foundation's Coastal Ocean Processes program (CoOP) was conducted near Duck, North Carolina in the southern porton of the Middle Atlantic Bight. The field program took place from August to December, 1994 and included both moored and shipboard measurements of physical, biological and sedimentological variables. This report summarizes the observations from one component of this field program, a moored array of physical oceanographic and meteorological instruments. This component of the field program consisted of a cross-shelf array of three surface/subsurface mooring pairs in 13 m, 20 m and 25 m of water supporting instruments to measure currents, temperature and conductivity, a suite of meteorological instruments on surface buoys at the 20 -m and 25 -m site, and an along-shelf array of temperature, conductivity and bottom pressure sensors mounted on jetted pipes along the 5-m isobath and on moorings along the 20-m isobath. The report includes descriptions of the cross-shelf and along-shelf arrays, the four types of instruments used (VAWRs, VMCMs, SeaCats, and SeaGauges), and the data return from the field program. Statistical and graphical summaries of the atmospheric (wind, air temperature, barometric pressure, relative humidity, short- and long-wave radiation), and oceanic (current, water temperature, conductivity and bottom pressure) measurements are presented.Funding was provided by the National Science Foundation through Grant No. OCE-9221615

Exceptional aggressiveness of cerebral cavernous malformation disease associated with PDCD10 mutations.

PurposeThe phenotypic manifestations of cerebral cavernous malformation disease caused by rare PDCD10 mutations have not been systematically examined, and a mechanistic link to Rho kinase-mediated hyperpermeability, a potential therapeutic target, has not been established.MethodsWe analyzed PDCD10 small interfering RNA-treated endothelial cells for stress fibers, Rho kinase activity, and permeability. Rho kinase activity was assessed in cerebral cavernous malformation lesions. Brain permeability and cerebral cavernous malformation lesion burden were quantified, and clinical manifestations were assessed in prospectively enrolled subjects with PDCD10 mutations.ResultsWe determined that PDCD10 protein suppresses endothelial stress fibers, Rho kinase activity, and permeability in vitro. Pdcd10 heterozygous mice have greater lesion burden than other Ccm genotypes. We demonstrated robust Rho kinase activity in murine and human cerebral cavernous malformation vasculature and increased brain vascular permeability in humans with PDCD10 mutation. Clinical phenotype is exceptionally aggressive compared with the more common KRIT1 and CCM2 familial and sporadic cerebral cavernous malformation, with greater lesion burden and more frequent hemorrhages earlier in life. We first report other phenotypic features, including scoliosis, cognitive disability, and skin lesions, unrelated to lesion burden or bleeding.ConclusionThese findings define a unique cerebral cavernous malformation disease with exceptional aggressiveness, and they inform preclinical therapeutic testing, clinical counseling, and the design of trials.Genet Med 17 3, 188-196

Comparison of DrugResponses in Vivoandin VitroinAirwaysof DogswithandwithoutAirwayHyperresponsiveness&apos;

ABSTRACT muscle were 7.03 ±0.11 in BG dogs and 7.50 ±0.11 in greyhounds. A significant (P &lt; .01) negative correlation was found between methacholine sensitivity in vivo and in vitro. Aerosol concentrations of histamine required to produce a 2-fold increase in pulmonary reaistance were 0. determined against a half-maximai methacholine contraction. Aerosol methacholine concentrations required to produce a 2-fold increase in pulmonary resistance were 0.07 ±0.02 (±S.E.) mg/mI in BG dogs and 0.67 ±0.26 mg/mI in greyhounds; pD2 values for methacholine-inducedcontraction ofcervical trachealis In the search for the defect underlying asthma, mechanical and biochemical properties of airway smooth muscle have been compared in unsensitized and antigen-sensitized animals of several species. Although differences in drug responses have been found (Souhrada, 1978; Antonissen et at., 1979; In contrast to most animal models of asthma, the BG mechanical responses to methacholine, histamine and isopro terenol in isolated trachealis muscle preparations of five BG and five unrelated greyhounds, which had been tested previ ously for sensitivity to methacholine and histamine aerosols in vivo. Methods Subjects. The studies were performed in five BG dogs and five unrelated greyhounds that were age matched (â€&quot;2 years old) and housed under identical conditions in the animal quarters at Oregon Health Sciences University. BG dogs ranged from 18 to 23 kg and greyhounds from 27 to 37 kg. All animals had been selected especially for this study, and had not been tested previously as part of other ongoing studies. 21

Synthesis and study of novel multifunctional cyclodextrin‐deferasirox hybrids

Metal dyshomeostasis is central to a number of disorders that result from, inter alia, oxidative stress protein misfolding, and cholesterol dyshomeostasis. In this respect, metal deficiencies are usually readily corrected by treatment with supplements, whereas metal overload can be overcome by the use of metal‐selective chelation therapy. Deferasirox, 4‐[(3Z,5E)‐3,5‐bis(6‐oxo‐1‐cyclohexa‐2,4‐dienylidene)‐1,2,4‐triazolidin‐1‐yl]benzoic acid, Exjade, or ICL670, is used clinically to treat hemosiderosis (iron overload), which often results from multiple blood transfusions. Cyclodextrins are cyclic glucose units that are extensively used in the pharmaceutical industry as formulating agents as well as for encapsulating hydrophobic molecules such as in the treatment of Niemann Pick C or for hypervitaminosis. We have conjugated deferasirox, via an amide coupling reaction, to both 6A‐amino‐6A‐deoxy‐β‐cyclodextrin and 3A‐amino‐3A‐deoxy‐2A(S),3A(R)‐β‐cyclodextrin, at the upper and lower rim respectively creating hybrid molecules with dual properties, capable of both metal chelation and cholesterol encapsulation. Our findings emphasize the importance of the conjugation of β‐cyclodextrin with deferasirox to significantly improve the biological properties and reduce the cytotoxicity of this drug