Self- and informant-reported personality traits and vaccination against COVID-19

As COVID-19 vaccines’ accessibility has grown, so has the role of personal choice in vaccination, and not everybody is willing to vaccinate. Exploring personality traits’ associations with vaccination could highlight some person-level drivers of, and barriers to, vaccination. We used self- and informant-ratings of the Five-Factor Model domains and their subtraits (a) measured approximately at the time of vaccination with the 100 Nuances of Personality (100NP) item pool (N = 56,575) and (b) measured on average ten years before the pandemic with the NEO Personality Inventory-3 (NEO-PI-3; N = 3,168). We tested individual domains’ and either items’ (in the 100NP sample) or facets’ (in the NEO-PI-3 sample) associations with vaccination, as well as their collective ability to predict vaccination using elastic net models trained and tested in independent sample partitions. Although the NEO-PI-3 domains and facets did not predict vaccination ten years later, the domains correlated with vaccination in the 100NP sample, with vaccinated people scoring slightly higher on neuroticism and agreeableness and lower on openness, controlling for age, sex, and education. Collectively, the five domains predicted vaccination with an accuracy of r = .08. Associations were stronger at the item level. Vaccinated people were, on average, more science-minded, politically liberal, respectful of rules and authority, and anxious, but less spiritual, religious, and self-assured. The 100NP items collectively predicted vaccination with r = .31 accuracy. We conclude that unvaccinated people may be a psychologically heterogeneous group and highlight some potential areas for action in vaccination campaigns

Self- and informant-reported personality traits and vaccination against COVID-19

As COVID-19 vaccines’ accessibility has grown, so has the role of personal choice in vaccination, and not everybody is willing to vaccinate. Exploring personality traits’ associations with vaccination could highlight some person-level drivers of, and barriers to, vaccination. We used self- and informant-ratings of the Five-Factor Model domains and their subtraits (a) measured approximately at the time of vaccination with the 100 Nuances of Personality (100NP) item pool (N = 56,575) and (b) measured on average ten years before the pandemic with the NEO Personality Inventory-3 (NEO-PI-3; N = 3,168). We tested individual domains’ and either items’ (in the 100NP sample) or facets’ (in the NEO-PI-3 sample) associations with vaccination, as well as their collective ability to predict vaccination using elastic net models trained and tested in independent sample partitions. Although the NEO-PI-3 domains and facets did not predict vaccination ten years later, the domains correlated with vaccination in the 100NP sample, with vaccinated people scoring slightly higher on neuroticism and agreeableness and lower on openness, controlling for age, sex, and education. Collectively, the five domains predicted vaccination with an accuracy of r = .08. Associations were stronger at the item level. Vaccinated people were, on average, more science-minded, politically liberal, respectful of rules and authority, and anxious but less spiritual, religious, and self-assured. The 100NP items collectively predicted vaccination with r = .31 accuracy. We conclude that unvaccinated people may be a psychologically heterogeneous group and highlight some potential areas for action in vaccination campaigns

Cohort profile: Personality Measurements at the Estonian Biobank of the Estonian Genome Center, University of Tartu

Like all behaviour, personality traits are substantially heritable, but their genetic background is poorly understood. Investigating traits’ genetic background could help explain disparities in health and other life outcomes that the traits likely contribute to. We describe two cohorts of the Estonian Biobank for whom, besides self- and informant-rated personality traits, detailed data are available on health behaviour, medical diagnoses and treatments, and biomarkers, among others. The first cohort (N = 3,640) filled out the NEO-PI-3 between 2008 and 2018. The second, partially overlapping cohort (N = 77,400) responded to a large and diverse item pool called the Hundred Nuances of Personality (100NP) covering the Big Five and other traits between 2021 and 2022. Research opportunities include gene discovery, health and well-being prediction, and causal modeling. New data are added periodically through additional data collection waves and linkage with various registries and databases

Diastereoselective Multicomponent Cascade Reaction Leading to [3.2.0]-Heterobicyclic Compounds

A general three-component triple cascade reaction through an iminium–enamine–iminium sequential activation initiated by a hetero-Michael addition to α,β-unsaturated aldehydes affords [3.2.0]­heterobicycles in high diastereoselectivity. The rate and diastereoselectivity of the reaction depended on the (<i>E</i>)-4-heterocrotonate and size of the secondary amine. The enantiomers of the major diastereoisomer of oxa- and azabicyclo[3.2.0]­heptane derivatives were separated by enzymatic kinetic resolution with immobilized <i>Candida antarctica</i> Lipase B (CALB), with <i>E</i> values up to 153. The absolute configuration of the nonacylated enantiomer of oxabicyclo[3.2.0]­heptane was determined by single crystal X-ray analysis

Diastereoselective Multicomponent Cascade Reaction Leading to [3.2.0]-Heterobicyclic Compounds

A general three-component triple cascade reaction through an iminium–enamine–iminium sequential activation initiated by a hetero-Michael addition to α,β-unsaturated aldehydes affords [3.2.0]­heterobicycles in high diastereoselectivity. The rate and diastereoselectivity of the reaction depended on the (<i>E</i>)-4-heterocrotonate and size of the secondary amine. The enantiomers of the major diastereoisomer of oxa- and azabicyclo[3.2.0]­heptane derivatives were separated by enzymatic kinetic resolution with immobilized <i>Candida antarctica</i> Lipase B (CALB), with <i>E</i> values up to 153. The absolute configuration of the nonacylated enantiomer of oxabicyclo[3.2.0]­heptane was determined by single crystal X-ray analysis

NEO-PI-3 domains and facets predicting vaccination status.

The associations are reported numerically in S13 Table. None of the correlations reached statistical significance.</p

Sample characteristics: Vaccination details.

As COVID-19 vaccines’ accessibility has grown, so has the role of personal choice in vaccination, and not everybody is willing to vaccinate. Exploring personality traits’ associations with vaccination could highlight some person-level drivers of, and barriers to, vaccination. We used self- and informant-ratings of the Five-Factor Model domains and their subtraits (a) measured approximately at the time of vaccination with the 100 Nuances of Personality (100NP) item pool (N = 56,575) and (b) measured on average ten years before the pandemic with the NEO Personality Inventory-3 (NEO-PI-3; N = 3,168). We tested individual domains’ and either items’ (in the 100NP sample) or facets’ (in the NEO-PI-3 sample) associations with vaccination, as well as their collective ability to predict vaccination using elastic net models trained and tested in independent sample partitions. Although the NEO-PI-3 domains and facets did not predict vaccination ten years later, the domains correlated with vaccination in the 100NP sample, with vaccinated people scoring slightly higher on neuroticism and agreeableness and lower on openness, controlling for age, sex, and education. Collectively, the five domains predicted vaccination with an accuracy of r = .08. Associations were stronger at the item level. Vaccinated people were, on average, more science-minded, politically liberal, respectful of rules and authority, and anxious but less spiritual, religious, and self-assured. The 100NP items collectively predicted vaccination with r = .31 accuracy. We conclude that unvaccinated people may be a psychologically heterogeneous group and highlight some potential areas for action in vaccination campaigns.</div

Personality items most strongly associated with vaccination status.

Personality items most strongly associated with vaccination status.</p

Trait-level associations in the demographic groups with lowest vaccination rates.

Trait-level associations in the demographic groups with lowest vaccination rates.</p