CP violation in b->c anti-c d decays at Belle

We report a measurement of the CP violation parameters in b->c anti-c d decays. Mixing-induced CP violation involving this transition is studied using a sample of B0->J/psi pi0, D*+D*- and D*+-D-+ decays with a data set accumulated at the Upsilon(4S) resonance with the Belle detector at the KEKB energy-asymmetric e+e- collider. CP violation parameters are extracted from a fit to the distributions of time intervals between two B0 meson decay vertexes.Comment: 4 pages + 7 figure

Measurements of the CKM angle ϕ3/γ\phi_3/\gamma

In this report we summarize the most recent results of measurements of the angle $\gamma/\phi_3$ of the Unitarity Triangle.Comment: 4 pages proceedings for CIPANP'09 conferenc

The neutron 'thunder' accompanying large extensive air showers

The bulk of neutrons which appear with long delays in neutron monitors nearby the EAS core (~'neutron thunder'~) are produced by high energy EAS hadrons hitting the monitors. This conclusion raises an important problem of the interaction of EAS with the ground, the stuff of the detectors and their environment. Such interaction can give an additional contribution to the signal in the EAS detectors at {\em km}-long distances from the large EAS core after a few $\mu s$ behind the EAS front.Comment: 4 pages, 2 figures, to appear in Proc. of 14th Int. Symp. on Very High Energy Cosmic Ray Interactions, Weihai, China, 15-22 August 2006, to be published in Nucl. Phys. B (Proc.Suppl.), 200

Monte Carlo simulations of ultra high energy secondary neutrino detection in the DUNE experiment

In this research we do an evaluation on expected secondary neutrino flux in the DUNE detector from ultra high energy cosmic rays. Using Monte Carlo simulation software SimProp v.2.r.4. spectra of ultra high energy secondary neutrinos were obtained, and their flux on the Earth was evaluated. Two different primary sources (free protons and 56Fe cores) that correspond to different cosmic rays origins were used. For the calculations the source was considered to have cosmic ray injection power as L≈1045 erg/year. Simulations were conducted at three distances (in terms of redshift z): z = 0.1, z = 1.0 and z = 3.0. Numbers of secondary neutrino events in DUNE over 1 year is expected to be: 39.7, 0.17 and 0.006 for protons and 0.006, 0.0002 and 1.6 • 10−5 for 56Fe cores accordingly

OTUB1 triggers lung cancer development by inhibiting RAS monoubiquitination

Activation of the RAS oncogenic pathway, frequently ensuing from mutations in RAS genes, is a common event in human cancer. Recent reports demonstrate that reversible ubiquitination of RAS GTPases dramatically affects their activity, suggesting that enzymes involved in regulating RAS ubiquitination may contribute to malignant transformation. Here, we identified the de-ubiquitinase OTUB1 as a negative regulator of RAS mono- and di-ubiquitination. OTUB1 inhibits RAS ubiquitination independently of its catalytic activity resulting in sequestration of RAS on the plasma membrane. OTUB1 promotes RAS activation and tumorigenesis in wild-type RAS cells. An increase of OTUB1 expression is commonly observed in non-small-cell lung carcinomas harboring wild-type KRAS and is associated with increased levels of ERK1/2 phosphorylation, high Ki67 score, and poorer patient survival. Our results strongly indicate that dysregulation of RAS ubiquitination represents an alternative mechanism of RAS activation during lung cancer development