Ultrasound-assisted multicomponent synthesis of 4H-pyrans in water and DNA binding studies

A simple approach to synthesize new highly substituted 4H-pyran derivatives is described. Efficient Et3N acts as a readily accessible catalyst of this process performed in pure water and with only a 20 mol% of catalyst loading. The extremely simple operational methodology, short reaction times, clean procedure and excellent product yields render this new approach extremely appealing for the synthesis of 4H-pyrans, as potentially biological scaffolds. Additionally, DNA interaction analysis reveals that 4H-pyran derivatives behave preferably as minor groove binders over major groove or intercalators. Therefore, this is one of the scarce examples where pyrans have resulted to be interesting DNA binders with high binding constants (Kb ranges from 1.53 × 104 M-1 to 2.05 × 106 M-1)

Post-test analysis of PIPER-ONE PO-IC-2 experiment by RELAP5/MOD3 codes

RELAP5/MOD3.1 was applied to the PO-IC-2 experiment performed in PIPER-ONE facility, which has been modified to reproduce typical isolation condenser thermal-hydraulic conditions. RELAP5 is a well known code widely used at the University of Pisa during the past seven years. RELAP5/MOD3.1 was the latest version of the code made available by the Idaho National Engineering Laboratory at the time of the reported study. PIPER-ONE is an experimental facility simulating a General Electric BWR-6 with volume and height scaling ratios of 1/2,200 and 1./1, respectively. In the frame of the present activity a once-through heat exchanger immersed in a pool of ambient temperature water, installed approximately 10 m above the core, was utilized to reproduce qualitatively the phenomenologies expected for the Isolation Condenser in the simplified BWR (SBWR). The PO-IC-2 experiment is the flood up of the PO-SD-8 and has been designed to solve some of the problems encountered in the analysis of the PO-SD-8 experiment. A very wide analysis is presented hereafter including the use of different code versions

Holomorphic Anomalies in Topological Field Theories

We study the stringy genus one partition function of $N=2$ SCFT's. It is shown how to compute this using an anomaly in decoupling of BRST trivial states from the partition function. A particular limit of this partition function yields the partition function of topological theory coupled to topological gravity. As an application we compute the number of holomorphic elliptic curves over certain Calabi-Yau manifolds including the quintic threefold. This may be viewed as the first application of mirror symmetry at the string quantum level.Comment: 32 pages. Appendix by S.Kat

Tailoring the dielectric and ferroelectric response of mixtures containing bent-core liquid crystals through light-irradiation and composition

Open access via the Elsevier Agreement IDC would like to thank the Universitat Politècnica de València (UPV), for the FPI grant (PAID-2019-SP20190013), the Generalitat Valenciana (GVA) and the European Social Fund (ESF), for the FPI grant (ACIF/2020/233) and the mobility grant (CIBEFP/2022/45). AMF would like to thank the Carnegie Trust for the Universities of Scotland, for the Research Incentive Grant RIG008586, the Royal Society and Specac Ltd., for the Research Grant RGS\R1\201397, the Royal Society of Chemistry for the award of a mobility grant (M19- 0000), the Scottish Government and the Royal Society of Edinburgh for the award of a SAPHIRE project, NHS Scotland for the 20/016 R&D Endowments Award, and the University of Aberdeen for the CF10801-10 and CF10723-44 pump priming grants. The authors from INMA greatly appreciate financial support from projects of the Spanish Government PID2021-122882NB-I00 [MCIU/AEI/FEDER, UE] and the Gobierno de Aragón/FEDER (research group E47_23R); and C.A-S for the FPI Fellowship PRE2019-090773. Thanks are given to the nuclear magnetic resonance, mass spectrometry, and thermal analysis services of CEQMA (Univ. Zaragoza-CSIC). BC is grateful to the National Science Foundation for supporting this work under grant no. CHE- 2306317. BC also thanks Illinois State University (ISU) for their financial support through university research grant (URG). Computational work is performed using resources from High Performance Computing (HPC) at Illinois State University.Peer reviewe

Superbrane Actions and Geometrical Approach

We review a generic structure of conventional (Nambu-Goto and Dirac-Born-Infeld-like) worldvolume actions for the superbranes and show how it is connected through a generalized action construction with a doubly supersymmetric geometrical approach to the description of super-p-brane dynamics as embedding world supersurfaces into target superspaces.Comment: Based on talks given by the authors at the Volkov Memorial Seminar "Supersymmetry and Quantum field Theory" (Kharkov, January 5-7, 1997), LaTeX file, 11 pages Misprints corrected, references adde

Lorentz harmonics and superfield action. D=10, N=1 superstring

We propose a new version of the superfield action for a closed D=10, N=1 superstring where the Lorentz harmonics are used as auxiliary superfields. The incorporation of Lorentz harmonics into the superfield action makes possible to obtain superfield constraints of the induced worldsheet supergravity as equations of motion. Moreover, it becomes evident that a so-called 'Wess-Zumino part' of the superfield action is basically a Lagrangian form of the generalized action principle. We propose to use the second Noether theorem to handle the essential terms in the transformation lows of hidden gauge symmetries, which remove dynamical degrees of freedom from the Lagrange multiplier superfield.Comment: 23 pages, latex, no figures. V.2, minor corrections, a reference adde

Generalized action principle and extrinsic geometry for N=1 superparticle

It is proposed the generalized action functional for N=1 superparticle in D=3,4,6 and 10 space-time dimensions. The superfield geometric approach equations describing superparticle motion in terms of extrinsic geometry of the worldline superspace are obtained on the base of the generalized action. The off-shell superdiffeomorphism invariance (in the rheonomic sense) of the superparticle generalized action is proved. It was demonstrated that the half of the fermionic and one bosonic (super)fields disappear from the generalized action in the analytical basis. Superparticle interaction with Abelian gauge theory is considered in the framework of this formulation. The geometric approach equations describing superparticle motion in Abelian background are obtained.Comment: 31 pages. Late

Linfoma de Hodgkin refractario con afectación ósea y esplénica con rápida y completa respuesta a Nivolumab

Abstract [PB-062] Introducción: En el linfoma de Hodgkin (LH) las alteraciones genéticas del cromosoma 9p24.1 de la célula de Reed-Sternberg, causan una sobreexpresión del ligando 1 de muerte programada (PDL-1), que conducen a una evasión del sistema inmune y resistencia terapéutica. Para pacientes que recaen después de un trasplante autólogo y de tratamiento con Brentuxumab, existen pocas posibilidades. Basándose en la sobreexpresión del PDL-1, los inhibidores de PD1/PDL1 son una opción. Nivolumab (anti PD1) ha demostrado eficacia en LH recaído/refractario (R/R). Presentamos un caso con respuesta clínica completa rápida en un LH refractario a Brentuximab y con gran afectación extranodal (ósea y esplénica). Paciente y Métodos: Varón de 55 años diagnosticado de LH celularidad mixta estadio IIIA en Junio de 2005. 1ª línea: ABVDx6 y radioterapia mediastínica con RC. 2ª línea (Enero 2009) por recidiva cervical: Ifosfamida, Vinorelbina y Prednisona con RC. 3ª línea (Junio 2009) con afectación cervical y retoperitoneal: cisplatino, citarabina y dexametasona más radioterapia cervical con RC. 4ª línea (Enero 2011): MOPPx4 y Rituximab Gemcitabina con RC. Pasa a Hematología y se realiza autotrasplante en Noviembre de 2011 con RC. 5ª línea (Noviembre 2016) por afectación cervical, retroperitoneal, esplénica e iliaco: Brentuximabx4 y por mala respuesta se añade Bendamustinax3 con RC. Tras finalizar se realiza PET/TAC (Junio 2017) siendo negativo. En Agosto de 2017 importante clínica con síntomas constitucionales, pérdida de 10 Kg de peso en un mes. Analítica: Hb: 11, 5 g/dl, leucocitos: 2x109/l, plaquetas: 57x109/l. VSG: 120, PCR: 14 mg/dl, metabolismo hierro de proceso crónico. TAC: no adenopatías, esplenomegalia con lesiones. Biopsia de MO: afectación hodgkiniana. Se solicita Nivolumab. Mientras autorización se instaura Gemcitabina-Oxaliplatinox4 con mejoría clínica. Se realiza PET/TAC previo Nivolumab (Noviembre 2017): extensa afectación ósea esqueleto axial y huesos largos y afectación esplénica. Se inicia Nivolumab (16 Noviembre) a 3 mg/kg/ 14 días. Respuesta clínica óptima. No efectos secundarios, ni clínicos, ni analíticos. Tras 9 ciclos se realiza PET/TAC de control con RC. Por edad, hipertratado y deseo del paciente se descarta trasplante alogénico. Continúa tratamiento con Nivolumab, sin ningún efecto adverso y estando previsto discontinuar al año. Conclusiones: Nivolumab es un fármaco que puede rescatar a pacientes con LH R/R a las terapias disponibles (trasplante y Brentuximab), donde las opciones son escasas. Puede servir como tratamiento puente para un trasplante alogénico y en pacientes no candidatos, como nuestro caso, su administración continua puede deparar en un aumento de la supervivencia libre de progresión y supervivencia global. Se necesita más investigación y seguimiento para valorar la duración de la respuesta y el tiempo o secuencia de administración