Seasonal effects on reconciliation in Macaca Fuscata Yakui

Dietary composition may have profound effects on the activity budgets, levelof food competition, and social behavior of a species. Similarly, in seasonally breeding species, the mating season is a period in which competition for mating partners increases, affecting amicable social interactions among group members. We analyzed the importance of the mating season and of seasonal variations in dietary composition and food competition on econciliation in wild female Japanese macaques (Macaca fuscata yakui) on Yakushima Island, Japan. Yakushima macaques are appropriate subjects because they are seasonal breeders and their dietary composition significantly changes among the seasons. Though large differences occurred between the summer months and the winter and early spring months in activity budgets and the consumption of the main food sources, i.e., fruits, seeds, and leaves, the level of food competition and conciliatory tendency remained unaffected. Conversely,conciliatory tendency is significantly lower during the mating season than in the nonmating season. Moreover, conciliatory tendency is lower when 1 or both female opponents is in estrous than when they are not. Thus the mating season has profound effects on reconciliation, whereas seasonal changes in activity budgets and dietary composition do not. The detrimental effects of the mating season on female social relationships and reconciliation may be due to the importance of female competition for access to male partners in multimale, multifemale societies

Deoxynivalenol content in italian organic durum wheat: Results of a six-year survey

Deoxynivalenol (DON) contamination was investigated of Italian durum wheat from organic agriculture. A number of 661 samples from 13 genotypes were collected within the national organic durum wheat network variety trials during the six-year period between 2007–2012 in five different growing areas across Italy (Northern Italy, Marches, Central Apennines, West-Central Italy, Apulia). Mean temperatures and total rainfalls in April, May and June were collected nearby the study sites. Average DON contamination value along the whole study period was 67 μg/kg, and DON was detected only in 36% of the samples. Noteworthy, 95% of the analyzed grain revealed a DON contamination lower than 334 μg/kg. Maximum allowed DON level for unprocessed durum wheat set by European Union (1750 μg/kg) was exceeded only in four samples (0.6%). The highest mean DON values were detected in Northern Italy (175 μg/kg) and Marches (131 μg/kg). The same was for the percentage of positive samples (80% and 58%, respectively). Lower mean values and percentages of contaminated samples were found in West-Central Italy (22 μg/kg and 29%, respectively), Apennines (3 μg/kg and 8%, respectively) and Apulia (2 μg/kg and 7%, respectively). Statistical analysis (Generalized Linear Model, GLZ) was carried out to highlight the effect of factors like cultivation year, growing area and genotype. It revealed a huge effect of year, growing areas and their interaction, while the effect of genotype resulted significantly but quite less than the other main factors. The effect of the year could be explained by climatic data, which suggested an influence of rainfall and temperature at heading on both DON concentration values and percentage of contaminated samples. Results of this study put in evidence a low DON contamination in Italian organic durum wheat

Massive measurements of 5G exposure in a town: methodology and results

We target the problem of performing a large set of measurements over the territory to characterize the exposure from a 5G deployment. Since using a single Spectrum Analyzer (SA) is not practically feasible (due to the limited battery duration), in this work we adopt an integrated approach, based on the massive measurement of 5G metrics with a 5G smartphone, followed by a detailed analysis done with the SA and an ElectroMagnetic Field (EMF) meter in selected locations. Results, obtained over a real territory covered by 5G signal, reveal that 5G exposure is overall very limited for most of measurement locations, both in terms of field strength (up to 0.7 [V/m]) and as share w.r.t. other wireless technologies (typically lower than 15%). Moreover, our approach allows easily spotting measurement outliers, e.g., due to the exploitation of Dynamic Spectrum Sharing (DSS) techniques between 4G and 5G. In addition, the exposure metrics collected with the smartphone are overall a good proxy of the total exposure measured over the whole 5G channel. Moreover, the sight conditions and the distance from 5G base station play a great role in determining the level of exposure. Finally, a maximum of 130 [W] of power radiated by a 5G base station is estimated in the scenario under consideration

Application of the Maximum Power Extrapolation Procedure for Human Exposure Assessment to 5G Millimeter Waves: Challenges and Possible Solutions

This paper describes an investigation on the application of the Maximum Power Extrapolation (MPE) technique on a fully operational Fixed Wireless Access (FWA) FR2-band 5G gNB. The data was acquired in [27.1-27.3] GHz band using a network scanner over nearly 10 minutes periods to allow a statistical analysis and an accurate estimation of the role of each contribution to the total uncertainty, including the fading affecting the 5G FR2 reference signal. The results show that the level of the electromagnetic field is well below the limits imposed by Italian legislation. However the goal of the paper is more fundamental, and shows an approach that can be used to identify the critical elements of the measurement set-up, suggesting where to concentrate efforts to improve the measurement procedure. In particular, the uncertainty budget highlights three contributions, (i.e. estimation of the traffic beam level, of the probe response and of the 5G FR2 reference signal) that deserve further investigations

How Much Exposure From 5G Towers Is Radiated Over Children, Teenagers, Schools and Hospitals?

The rolling-out of 5G antennas over the territory is a fundamental step to provide 5G connectivity. However, little efforts have been done so far on the exposure assessment from 5G cellular towers over young people and 'sensitive' buildings, like schools and medical centers. To face such issues, we provide a sound methodology for the numerical evaluation of 5G (and pre-5G) downlink exposure over children, teenagers, schools and medical centers. We then apply the proposed methodology over two real scenarios. Results reveal that the exposure from 5G cellular towers will increase in the forthcoming years, in parallel with the growth of the 5G adoption levels. However, the exposure levels are well below the maximum ones defined by international regulations. Moreover, the exposure over children and teenagers is similar to the one of the whole population, while the exposure over schools and medical centers can be lower than the one of the whole set of buildings. Finally, the exposure from 5G is strongly lower than the pre-5G one when the building attenuation is introduced and a maturity adoption level for 5G is assumed

Immunotherapy as a turning point in the treatment of acute myeloid leukemia

Acute myeloid leukemia (AML) is a malignant disease of hematopoietic precursors at the earliest stage of maturation, resulting in a clonalproliferation of myoblasts replacing normal hematopoiesis. AML represents one of the most common types of leukemia, mostly affecting elderly patients. To date, standard chemotherapy protocols are only effective in patients at low risk of relapse and therapy-related mortality. The average 5-year overall survival (OS) is approximately 28%. Allogeneic hematopoietic stem cell transplantation (HSCT) improves prognosis but is limited by donor availability, a relatively young age of patients, and absence of significant comorbidities. Moreover, it is associated with significant morbidity and mortality. However, increasing understanding of AML immunobiology is leading to the development of innovative therapeutic strategies. Immunotherapy is considered an attractive strategy for controlling and eliminating the disease. It can be a real breakthrough in the treatment of leukemia, especially in patients who are not eligible forintensive chemotherapy. In this review, we focused on the progress of immunotherapy in the field of AML by discussing monoclonal antibodies (mAbs), immune checkpoint inhibitors, chimeric antigen receptor T cells (CAR-T cells), and vaccine therapeutic choices

Variation in ligand responses of the bitter taste receptors TAS2R1 and TAS2R4 among New World monkeys.

BACKGROUND: New World monkeys (NWMs) are unique in that they exhibit remarkable interspecific variation in color vision and feeding behavior, making them an excellent model for studying sensory ecology. However, it is largely unknown whether non-visual senses co-vary with feeding ecology, especially gustation, which is expected to be indispensable in food selection. Bitter taste, which is mediated by bitter taste receptors (TAS2Rs) in the tongue, helps organisms avoid ingesting potentially toxic substances in food. In this study, we compared the ligand sensitivities of the TAS2Rs of five species of NWMs by heterologous expression in HEK293T cells and calcium imaging. RESULTS: We found that TAS2R1 and TAS2R4 orthologs differ in sensitivity among the NWM species for colchicine and camphor, respectively. We then reconstructed the ancestral receptors of NWM TAS2R1 and TAS2R4, measured the evolutionary shift in ligand sensitivity, and identified the amino acid replacement at residue 62 as responsible for the high sensitivity of marmoset TAS2R4 to colchicine. CONCLUSIONS: Our results provide a basis for understanding the differences in feeding ecology among NWMs with respect to bitter taste