Making data a first class scientific output : data citation and publication by NERC's Environmental Data Centres

The NERC Science Information Strategy Data Citation and Publication project aims to develop and formalise a method for formally citing and publishing the datasets stored in its environmental data centres. It is believed that this will act as an incentive for scientists, who often invest a great deal of effort in creating datasets, to submit their data to a suitable data repository where it can properly be archived and curated. Data citation and publication will also provide a mechanism for data producers to receive credit for their work, thereby encouraging them to share their data more freely

A Happy Abundance : Tales, Memoirs and More Past and Present in Wayne, Maine

https://digitalmaine.com/wayne_books/1002/thumbnail.jp

Chorioamnionitis: Case definition & guidelines for data collection, analysis, and presentation of immunization safety data

Chorioamnionitis is a term encompassing a broad spectrum of disease during pregnancy that is characterized by inflammation and/or infection of intrauterine structures such as the placenta, the chorion and amnion. The clinical presentation of chorioamnionitis can vary based on clinical, microbiologic, and histologic factors which interact and overlap to varying degrees

A Population-Based Evaluation of a Publicly Funded, School-Based HPV Vaccine Program in British Columbia, Canada: Parental Factors Associated with HPV Vaccine Receipt

Analysis of a telephone survey by Gina Ogilvie and colleagues identifies the parental factors associated with HPV vaccine uptake in a school-based program in Canada

УКРАЇНСЬКИЙ ДОСВІД ПРОФЕСІЙНОЇ ПІДГОТОВКИ МАЙБУТНІХ СОЦІАЛЬНИХ ПРАЦІВНИКІВ: ЗМІШАНА МОДЕЛЬ НАВЧАННЯ

Ukrainian social work faculty from Volodymyr Hnatyuk Ternopil National Pedagogical University worked with an American Fulbright Specialist in curriculum development as the faculty wanted a new perspective in teaching social work students. This study reports a social work generalist practice course using two pedagogies, Problem-Based Learning (PBL) and Team-Based Learning (TBL). The resulting course structure emphasized the Ukrainian faculty goals, in keeping with the Bologna Declaration and indicates the university’s commitment to social work education. This study pre and post tested students’ t-tests were conducted to measure practice knowledge, critical thinking, and professional conduct before the course and after the PBL-TBL blended pedagogy was utilized. There was a significant difference in the posttest scores for Practice Knowledge (M=78.7, SD=5.4) conditions t (-9.4) = df 19, p = .000. Similarly. Posttests scores for Critical Thinking (M =83.6, SD 5.1) conditions t (-7.8) = df 19; and, Professional Conduct (M=82., SD=7.3) conditions; t(-4.5)= df 19, p = .000. These results suggest that the PBL-TBL model really does influence Ukrainian social work students increase in knowledge. Specifically, our results suggest that when PBL-TBL is utilized, social work knowledge, critical thinking, and professional conduct increases.Кафедра соціальної педагогіки та соціальної роботи Тернопільського національного педагогічного університету імені Володимира Гнатюка співпрацювала з професором Університету Північного Кентукі, стипендіатом програми ім. Фулбрайта у процесі розробки освітніх програм з підготовки майбутніх соціальних працівників. Е пов’язано з тим, що кафедра прагнула нової перспективи у навчанні студентів за спеціальністю 231 «Соціальна робота». У цьому дослідженні повідомляється про практичний курс із соціальної роботи, в контексті викладання якого застосовано два підходи до організації навчального процесу: проблемне навчання (PBL) та командне навчання (TBL). Напрацьована структура курсу відображає цілі кафедри соціальної педагогіки та соціальної роботи, відповідає вимогам Болонської декларації та наголошує на важливості підготовки майбутніх соціальних працівників відповідно до місії університету. Експеримент, проведений в рамках дослідження, передбачав до- та після- тестування студентів з курсу та застосування t-тесту задля вимірювання практичних знань, критичного мислення та професійної спрямованість курсу до та після застосування змішаної моделі PBL-TBL. Результати засвідчили, що була суттєва різниця в оцінках практичних знань студентів після застосування змішаної моделі (M = 78,7, SD = 5,4) умови t (-9,4) = df 19, p = .000; збільшився рівень розвитку критичного мислення (M = 83,6, SD 5,1) умови t (-7,8) = df 19; та професійна спрямованість (M = 82., SD = 7,3); t (-4,5) = df 19, p = .000.) у студентів після застосування змішаної моделі. Ці результати свідчать про те, що модель PBL-TBL дійсно працюють та впливають на збільшення знань українських студентів із соціальної роботи. Зокрема, наші результати показують, що при використанні PBL-TBL знання про соціальну роботу, рівень критичне мислення та професійна спрямованість студентів зростають

Differential modulation of NMDA-stimulated [\u3csup\u3e3\u3c/sup\u3eH]dopamine release from rat striatum by neuropeptide Y and σ receptor ligands

Although the identity of the endogenous ligands for sigma (σ) receptors is unknown, neuropeptide Y (NPY) has been named as a possible candidate for a natural transmitter at these receptors. Using a superfusion system, we compared the effect of NPY on NMDA-stimulated [3H]dopamine release in rat striatum to that of the σ agonists (+)-pentazocine and BD737. In contrast to (+)-pentazocine- or BD737-mediated inhibition of release, NPY enhanced release. However, the same σ antagonists (BD1008, DuP734, haloperidol and DTG) that reverse (+)-pentazocine- or BD737-mediated inhibition, as well as a Y receptor antagonist, PYX-1, all reversed the enhancement. PYX-1 also reversed the (+)-pentazocine- and BD737-mediated inhibition of release. Peptide YY (PYY) and [Leu31,Pro34]NPY did not mimic the effect of NPY. NPY13-36 enhanced release to the same extent as NPY but the effect was not reversed by σ antagonists. Our findings are consistent with the potential role of NPY as an endogenous ligand for a subtype of σ receptor with characteristics different from Y1, Y2 and Y3 receptors but sensitive to PYX-1

Phencyclidine and dizocilpine modulate dopamine release from rat nucleus accumbens via σ receptors

Phencyclidine (PCP) binds to many sites in brain, including PCP receptors located within the N-methyl-D-aspartate (NMDA) receptor-operated cation channel and sigma (σ) receptors. In this study, we compare mechanisms by which PCP, dizocilpine (MK-801), the prototypical σ receptor agonist (+)- pentazocine, and the proposed endogenous σ receptor ligand neuropeptide Y regulate potassium (K+)-stimulated [3H]dopamine release from slices of rat nucleus accumbens. (+)-Pentazocine inhibits K+-stimulated [3H]dopamine release, and neuropeptide Y enhances it. Both effects are blocked by σ1 and neuropeptide Y receptor antagonists, suggesting possible inverse agonism at a subpopulation of σ/neuropeptide Y receptors. In contrast, PCP and MK-801 both enhance K+-stimulated [3H]dopamine release via σ1 and σ2 receptor subtypes, as demonstrated by antagonist sensitivity. Regulation of release by both (+)-pentazocine and neuropeptide Y persists in the presence of tetrodotoxin suggests that the σ/neuropeptide Y receptors mediating the modulation are located presynaptically on dopaminergic nerve terminals, but tetrodotoxin eliminates regulation by PCP and MK-801, suggesting that receptors mediating their effects are located upstream from dopaminergic nerve terminals

Neuropeptide Y-mediated enhancement of NMDA-stimulated [\u3csup\u3e3\u3c/sup\u3eH]dopamine release from rat prefrontal cortex is reversed by σ1 receptor antagonists

Sigma (σ) receptors are located in limbic areas, including the prefrontal cortex, where decreased dopamine levels have been linked to negative symptoms. Although the endogenous ligands for σ receptors are unknown, neuropeptide Y (NPY) has been named as the potential endogenous agonist at these receptors. NPY enhanced NMDA-stimulated [3H]dopamine release in rat prefrontal cortex. This was in contrast to the inhibition produced by the σ agonists (+)pentazocine and BD737. However, four σ antagonists, including one which is σ1 selective, that reverse (+)pentazocine- or BD737-mediated inhibition all reversed the NPY-mediated enhancement. In addition, PYX-1, a Y receptor antagonist, reversed both the (+)pentazocine- and BD737-mediated inhibition and the NPY-mediated enhancement of release. Peptide YY (PYY). [Leu34,Pro34]Npy and NPY13-36, did not mimic the effect of NPY. Our findings are consistent with NPY acting as an endogenous ligand for a subtype of a receptor with characteristics different from Y1, Y2 and Y3 receptors but sensitive to PYX-I. These findings suggest a role for NPY, via σ receptors, as a modulator of dopamine levels in the prefrontal cortex

SH-SY5Y cells as a model for sigma receptor regulation of potassium- stimulated dopamine release

Previous studies in our laboratory using rat brain tissue have shown that neuropeptide Y (NPY) can enhance NMDA- and potassium-stimulated dopamine release from various brain regions and that this enhancement is reversed by sigma (σ) receptor antagonists. In the current study, we sought to determine whether SH-SY5Y cells are suitable for investigating σ receptor effects and whether any σ receptors present are of the subtype responsive to NPY. We compare mechanisms by which the prototypical σ receptor agonist (+)- pentazocine, and the proposed endogenous σ receptor ligand NPY regulate potassium-stimulated [3 H]dopamine release from SH-SY5Y cells. Both (+)- pentazocine and NPY inhibit potassium-stimulated [3 H]dopamine release. Unlike our studies in rat brain tissue, the effect of NPY on [3 H]dopamine release is not reversed by σ receptor antagonists. SH-SY5Y cells appear to be an appropriate model to study the regulation of dopamine release by σ receptors or by NPY receptors, but this population is not identical to that population identified in brain slices. (C) 2000 Elsevier Science B.V