Rejoinder: Quantifying the Fraction of Missing Information for Hypothesis Testing in Statistical and Genetic Studies

Rejoinder to "Quantifying the Fraction of Missing Information for Hypothesis Testing in Statistical and Genetic Studies" [arXiv:1102.2774]Comment: Published in at http://dx.doi.org/10.1214/08-STS244REJ the Statistical Science (http://www.imstat.org/sts/) by the Institute of Mathematical Statistics (http://www.imstat.org

Quantifying the Fraction of Missing Information for Hypothesis Testing in Statistical and Genetic Studies

Many practical studies rely on hypothesis testing procedures applied to data sets with missing information. An important part of the analysis is to determine the impact of the missing data on the performance of the test, and this can be done by properly quantifying the relative (to complete data) amount of available information. The problem is directly motivated by applications to studies, such as linkage analyses and haplotype-based association projects, designed to identify genetic contributions to complex diseases. In the genetic studies the relative information measures are needed for the experimental design, technology comparison, interpretation of the data, and for understanding the behavior of some of the inference tools. The central difficulties in constructing such information measures arise from the multiple, and sometimes conflicting, aims in practice. For large samples, we show that a satisfactory, likelihood-based general solution exists by using appropriate forms of the relative Kullback--Leibler information, and that the proposed measures are computationally inexpensive given the maximized likelihoods with the observed data. Two measures are introduced, under the null and alternative hypothesis respectively. We exemplify the measures on data coming from mapping studies on the inflammatory bowel disease and diabetes. For small-sample problems, which appear rather frequently in practice and sometimes in disguised forms (e.g., measuring individual contributions to a large study), the robust Bayesian approach holds great promise, though the choice of a general-purpose "default prior" is a very challenging problem.Comment: Published in at http://dx.doi.org/10.1214/07-STS244 the Statistical Science (http://www.imstat.org/sts/) by the Institute of Mathematical Statistics (http://www.imstat.org

A head-up display for mid-air drone recovery

During mid-air retrieval of parachute packages, the absence of a natural horizon creates serious difficulties for the pilot of the recovery helicopter. A head-up display (HUD) was tested in an attempt to solve this problem. Both a roll-stabilized HUD and a no-roll (pitch only) HUD were tested. The results show that fewer missed passes occurred with the roll-stabilized HUD when the horizon was obscured. The pilots also reported that the workload was greatly reduced. Roll-stabilization was required to prevent vertigo when flying in the absence of a natural horizon. Any HUD intended for mid-air retrieval should display pitch, roll, sideslip, airspeed, and vertical velocity

Alien Registration- Bergerson, Augustine L. (Auburn, Androscoggin County)

https://digitalmaine.com/alien_docs/30871/thumbnail.jp

Status of marine fisheries at Cochin Fisheries Harbour

Cochin Fisheries Harbour is the major fishing harbour in Ernakulam district of Kerala State, which contributes 6 to 11% of the annual state landings. It have berthing facilities for 60 deep sea trawlers and 900 smaller fishing vessels besides country crafts. This report presents gearwise and seasonwise marine fish landings during the period 1971 to 2000

The Internet and National Security in Nigeria: A Threat-Import Discourse

The internet has been an important feature of modernization. Paradoxically, it has also been a veritable threat to security of nations. The implication of the internet as a security threat has been amply demonstrated in the rising incidence of cyber criminality across the world. The apparent virtual un-governability of the cyber space in Nigeria has provided a platform for the perpetration of cyber crimes, such as advanced fee fraud, terrorist recruiting and financing, hate speech, and ideo-religious radicalization, etc. Adopting a threat-import approach, predicated on secondary sources, this paper posits that poor governance of Nigeria’s cyber space has presented an opportunity for high incidence and prevalence of cyber malaise in the country. The paper submits that the prospect of mitigating the challenge rests with the entrenchment of a multi-stakeholder vigilant and resilient cyber security regimen capable of countering the activities of cyber criminals in a pro-active and co-ordinated manner

Managing joint pain in osteoarthritis: safety and efficacy of hylan G-F 20

The use of intra-articular viscosupplementation in the nonoperative management of patients with osteoarthritis has become quite popular. Recent clinical data have demonstrated that the anti-inflammatory and chondroprotective actions of hyaluronic acid viscosupplementation reduce pain while improving patient function. We review the basic science and development of viscosupplementation and discuss the mounting evidence in support of the efficacy and safety profile of hylan G-F 20. Recent evidence suggesting a disease-modifying effect of hylan G-F 20 is also assessed. Furthermore, although the primary focus of this article is on treatment of osteoarthritis of the knee, we also discuss the use of viscosupplementation in other joints, such as the hip, ankle, and shoulder