Karvės tešmens ketvirčių temperatūros kontrolės kompiuterizuota matavimo sistema

Santr. angl., rusBibliogr.: p.82 (6 pavad.)Vytauto Didžiojo universitetasŽemės ūkio akademij

Angular and chromatic dispersion in Kerr-driven conical emission

We report measurements of ultrashort optical pulse filamentation in Kerr media with normal dispersion. We measure the angular dispersion of spontaneously generated colored conical emission and show that for large frequency shifts from the input pump frequency, it is well described by a relation between angle and frequency with slope determined solely by material chromatic dispersion. This measurement is in agreement with recent models that interpret filamentation dynamics in terms of the spontaneous formation of nonlinear X-waves. Finally, experimental results of filamentation in air show, for the first time, that the interpretation of CE in terms of X-waves may be also extended to gaseous medi

Investigation of in vitro and in vivo digestibility of black soldier fly (Hermetia illucens L.) larvae protein

In this work, the in vitro and in vivo digestibility of the dried and low-fat black soldier fly (BSF, Hermetia illucens L.) larvae was carried out. The in vitro experiments demonstrated that the digestibility of the dried larvae protein was only 48%. Meanwhile, the protein digestibility of the defatted larvae biomass reached 75%. Based on these findings, the experimental feeds were composed: (a) control feed containing casein, (b) test feed containing defatted larvae biomass and (c) protein-free feed. For protein digestibility studies, experimental feeds were tested in vitro and in vivo. It was found that digestibility of larvae protein in vivo and in vitro reached 85% and 41% respectively. The DIAAS value (73%) for BSF larvae protein digestibility in vivo was determined for the first time. The obtained results suggest that larvae possess an easy digestible AA, therefore, they can be used as highly bio-available protein source for human nutrition

Optical Mapping of the Pig Heart in Situ Under Artificial Blood Circulation

The emergence of optical imaging has revolutionized the investigation of cardiac electrical activity and associated disorders in various cardiac pathologies. The electrical signals of the heart and the propagation pathways are crucial for elucidating the mechanisms of various cardiac pathological conditions, including arrhythmia. The synthesis of near-infrared voltage-sensitive dyes and the voltage sensitivity of the FDA-approved dye Cardiogreen have increased the importance of optical mapping (OM) as a prospective tool in clinical practice. We aimed to develop a method for the high-spatiotemporal-resolution OM of the large animal hearts in situ using di-4-ANBDQBS and Cardiogreen under patho/physiological conditions. OM was adapted to monitor cardiac electrical behaviour in an open-chest pig heart model with physiological or artificial blood circulation. We detail the methods and display the OM data obtained using di-4-ANBDQBS and Cardiogreen. Activation time, action potential duration, repolarization time and conduction velocity maps were constructed. The technique was applied to track cardiac electrical activity during regional ischaemia and arrhythmia. Our study is the first to apply high-spatiotemporal-resolution OM in the pig heart in situ to record cardiac electrical activity qualitatively under artificial blood perfusion. The use of an FDA-approved voltage-sensitive dye and artificial blood perfusion in a swine model, which is generally accepted as a valuable pre-clinical model, demonstrates the promise of OM for clinical application

Understanding the Immunomodulatory Effects of Bovine Colostrum: Insights into IL-6/IL-10 Axis-Mediated Inflammatory Control

Bovine colostrum (COL), the first milk secreted by lactating cows postpartum, is a rich source of bioactive compounds that exert a significant role in the survival, growth, and immune development of neonatal calves. This study investigated the immunomodulatory effects of COL on cytokine production in vitro using a Caco-2/THP-1 macrophage co-culture model stimulated with Phorbol 12-myristate 13-acetate (PMA). COL pretreatment significantly reduced IL-6 (241.3 pg/mL) production induced by PMA (p S. typhimurium infection, in comparison to control animals (215.2 pg/mL). These results suggest the immunomodulatory activity of bovine colostrum and its potential applications in inflammatory disorders. Further studies are needed to elucidate the underlying mechanisms and validate the findings in bovine models

Evaluation of the Cardiac Electrophysiological and Haemodynamic Effects of <i>Elsholtzia ciliata</i> Essential Oil on Swine

The demand for the development of novel medicines with few side effects and no proarrhythmic properties is increasing. Extensive research on herbal extracts has been conducted with the expectation that the compounds will exert precise effects without harmful side effects. Elsholtzia ciliata (Thunb.) Hyl. essential oil (EO) possesses antiarrhythmic properties similar to those of class 1B antiarrhythmics, such as prolonging myocardial activation of the QRS complex and shortening the QT interval. In this study, we determined the kinetic profile of EO phytocompounds and the effects of EO on heart electrical activity and arterial blood pressure. For this study, we chose to use local breed pigs that were anaesthetized. The effects of an intravenous bolus of EO on ECG parameters, arterial blood pressure, heart rate variability, and blood levels of haematological and biochemical parameters were registered and evaluated. Following an intravenous injection of a bolus, EO exerted a vasodilatory effect, resulting in significant reductions in arterial blood pressure. EO also increased the heart rate and altered ECG parameters. The bolus of EO prolonged the QRS complex, shortened the QT interval, and nonmonotonically altered the PQ interval. After the administration of a bolus of EO, the activity of the autonomic nervous system was altered. This study confirms that EO possesses similar properties to class 1B antiarrhythmics and exerts a hypotensive effect; it reduces arterial blood pressure possibly by modulating peripheral vascular resistance