Fiber Optic Detection of Ammonia Gas

Bathochromic shifts accompanying the formation of several bivalent metallic complexes containing 5-(4’-dimethylaminophenylimino) quinolin-8-one (L1), and 7-chlore-5(4’-diethylamino-2-methylphenylimino) quinolin-8-one (L2) ligands in ethanol solutions were evaluated by VIS-NIR spectroscopy. The [L1-Cu-L1] sulphide complex was selected as a reagent for further tests on optical fibres. Samples of multimode siloxane-clad fused-silica fibre were sensitized by diffusing an ethanol/chloroform solution of the dye into the cladding polymer, and tested by VIS-NIR optical spectroscopy (12 cm long fibre sections), and optical time domain reflectometry (OTDR; 20 ns laser pulses, wavelength 850 nm, 120 m long fibre sensitized within the interval 104–110 m). A well-resolved absorption band of the reagent could be identified in the absorption spectra of the fibres. After exposure to dry ammonia/nitrogen gas with increasing ammonia concentration (0–4000 ppm), the short fibre samples showed subsequent decay of NIR optical absorption; saturation was observed for higher ammonia levels. The concentration resolution r ? 50 ppm and forward response time t90 ? 30 sec were obtained within the interval 0–1000 ppm. The OTDR courses showed an enhancement of the back-scattered light intensity coming from the sensitized region after diffusion of the initial reagent, and decay after exposure to concentrated ammonia/nitrogen gas (10000 ppm)

Discrete breathers in nonlinear lattices: Experimental detection in a Josephson array

We present an experimental study of discrete breathers in an underdamped Josephson-junction array. Breathers exist under a range of dc current biases and temperatures, and are detected by measuring dc voltages. We find the maximum allowable bias current for the breather is proportional to the array depinning current while the minimum current seems to be related to a junction retrapping mechanism. We have observed that this latter instability leads to the formation of multi-site breather states in the array. We have also studied the domain of existence of the breather at different values of the array parameters by varying the temperature.Comment: 5 pages, 5 figures, submitted to Physical Revie

Consistency tests of AMPCALCULATOR and chiral amplitudes in SU(3) Chiral Perturbation Theory: A tutorial based approach

Ampcalculator is a Mathematica based program that was made publicly available some time ago by Unterdorfer and Ecker. It enables the user to compute several processes at one-loop (upto $O(p^4)$) in SU(3) chiral perturbation theory. They include computing matrix elements and form factors for strong and non-leptonic weak processes with at most six external states. It was used to compute some novel processes and was tested against well-known results by the original authors. Here we present the results of several thorough checks of the package. Exhaustive checks performed by the original authors are not publicly available, and hence the present effort. Some new results are obtained from the software especially in the kaon odd-intrinsic parity non-leptonic decay sector involving the coupling $G_{27}$. Another illustrative set of amplitudes at tree level we provide is in the context of $\tau$-decays with several mesons including quark mass effects, of use to the BELLE experiment. All eight meson-meson scattering amplitudes have been checked. Kaon-Compton amplitude has been checked and a minor error in published results has been pointed out. This exercise is a tutorial based one, wherein several input and output notebooks are also being made available as ancillary files on the arXiv. Some of the additional notebooks we provide contain explicit expressions that we have used for comparison with established results. The purpose is to encourage users to apply the software to suit their specific needs. An automatic amplitude generator of this type can provide error-free outputs that could be used as inputs for further simplification, and used in varied scenarios such as applications of chiral perturbation theory at finite temperature, density and volume. This can also be used by students as a learning aid in low-energy hadron dynamics.Comment: 25 pages, plain latex, corresponds to version to appear in EPJA, additional ancillary files adde

Moving Forward in Human Cancer Risk Assessment

The goal of human risk assessment is to decide whether a given exposure level to a particular chemical or substance is acceptable to human health, and to provide risk management measures based on an evaluation and prediction of the effects of that exposure on human health. Within this framework, the current safety paradigm for assessing possible carcinogenic properties of drugs, cosmetics, industrial chemicals and environmental exposures relies mainly on in vitro genotoxicity testing followed by 2-year bioassays in mice and rats. This testing paradigm was developed 40 to 50 years ago with the initial premise that ¿mutagens are also carcinogens¿ and that the carcinogenic risk to humans can be extrapolated from the tumor incidence after lifetime exposure to maximally tolerated doses of chemicals in rodents. Genotoxicity testing is used as a surrogate for carcinogenicity testing and is required for initiation of clinical trials (Jacobs and Jacobson-Kram 2004) and for most industrial chemicals safety assessment. Although the carcinogenicity-testing paradigm has effectively protected patients and consumers from introduction of harmful carcinogens as drugs and other products, the testing paradigm is clearly not sustainable in the future. The causal link between genetic damage and carcinogenicity is well documented; however, the limitations of genotoxicity/carcinogenicity testing assays, the presence of additional non-genotoxic mechanisms, issues of species-specific effects, and the lack of mechanistic insights provide an enormous scientific challenge. The 2-year rodent carcinogenicity bioassays are associated with technical complexity, high costs, high animal burden as well as the uncertainty associated with extrapolating from rodents to humans. Additional frustrations exist because of the limited predictability of the 2-year bioassay and, in particular, with regard to the problem of the prediction of false positives. For instance, in the Carcinogenic Potency Project DataBase (CPDB) which includes results from chronic, long-term animal cancer tests with mice, rats, hamsters amounting to a total of 6540 individual experiments with 1547 chemicals, 751 of those chemicals or 51% have positive findings in rodent studies. Similarly, when one considers all chronically used human pharmaceuticals, some 50% induce tumors in rodents. Yet only 20 human pharmaceutical compounds have been identified as carcinogens in epidemiological studies, despite the fact that quite a large number of epidemiological studies have been carried out on these compounds, e.g. NSAID¿s, benzodiazepines, phenobarbital. This high incidence of tumors in bioassays has lead to questions concerning the human relevance of tumors induced in rodents (Knight et al. 2006; Ward 2008). In summary, dependency on the rodent model as a golden standard of cancer risk assessment is neglecting the high number of false positives and clearly has serious limitations. Consequently, there is a growing appeal for a paradigm change after "50 years of rats and mice". For instance, the current demands for volume of carcinogenic testing together with limitations of animal usage as initially stipulated by REACH (Combes et al. 2006) will require revolutionary change in the testing paradigm. For the purpose of developing a road map for this needed paradigm change in carcinogenicity testing, a workshop was held in August 2009 in Venice, Italy entitled ¿Genomics in Cancer Risk Assessment.¿ This workshop brought together toxicologists from academia and industry with governmental regulators and risk assessors from the US and the EU, for discussing the state-of-the-art in developing alternative testing strategies for genotoxicity and carcinogenicity, thereby focusing on the contribution from the ¿omics technologies. What follows is a highlight of the major conclusions and suggestions from this workshop as a path forward.JRC.DG.I.3-In-vitro method

Isospin Violation in tau -> 3 pi nu_tau

Isospin violating signals in the tau -> 3 pi nu_tau decay mode are discussed. For the tau -> pi^- pi^- pi^+ nu_tau decay mode, isospin violation arises from the vector current contribution in the tau -> omega pi nu_tau decay with the subsequent isospin violating omega decay into pi^+ pi^-. We demonstrate that such effects may be observed in presently available data through the measurement of the interference effects of these vector current contributions with the dominating axial vector current, i.e. through a measurement of the structure functions W_F,W_G,W_H and W_I. In the case of the tau -> pi^0 pi^0 pi^- nu_tau decay mode, a vector current contribution is generated by eta pi mixing in the decay chain tau -> eta rho nu_tau -> pi^0 pi^0 pi^- nu_tau. We find that this effect is rather small, the magnitude of the associated interference terms being too low for present statistics.Comment: LaTex, 16 pages, 5 figures. The complete paper is also available via anonymous ftp at ftp://ttpux2.physik.uni-karlsruhe.de/ , or via www at http://www-ttp.physik.uni-karlsruhe.de/cgi-bin/preprints

Precise measurement of hadronic tau-decays with an eta meson

We have studied hadronic tau decay modes involving an eta meson using 490 fb^{-1} of data collected with the Belle detector at the KEKB asymmetric-energy e+e- collider. The following branching fractions have been measured: B(tau- -> K- eta nu)=(1.58 +- 0.05 +- 0.09)x 10^{-4}, B(tau- -> K- pi0 eta nu)=(4.6 +- 1.1 +- 0.4)x 10^{-5}, B(tau- -> pi- pi0 eta nu)=(1.35 +- 0.03 +- 0.07)x 10^{-3}, B(tau- -> pi- KS eta nu)=(4.4 +- 0.7 +- 0.2)x 10^{-5}, and B(tau- -> K^{*-} eta nu)=(1.34 +- 0.12 +- 0.09)x 10^{-4}. These results are substantially more precise than previous measurements. The new measurements are compared with theoretical calculations based on the CVC hypothesis or the chiral perturbation theory. We also set upper limits on branching fractions for tau decays into K- KS eta nu, pi- KS pi0 eta nu, K- eta eta nu, pi- eta eta nu and non-resonant K- pi^0 eta nu final states.Comment: 24 pages, 7 figure

tau-->eta(eta')2pi nu, 3pi nu and WZW anomaly

The effects of the anomalous contact terms are taken into account in tau to eta(eta')2pi nu decay. tau to 3pi nu is computed. Theoretical result agrees with data. It is the first time the anomalous vertex eta aa is tested. An a_{1} resonance is predicted in the final state. The decay rate of tau to eta'3pi nu is predicted.Comment: 15 pages, one latex file for the paper and one p-script file for the figur