Updated tests of scaling and universality for the spin-spin correlations in the 2D and 3D spin-S Ising models using high-temperature expansions

We have extended, from order 12 through order 25, the high-temperature series expansions (in zero magnetic field) for the spin-spin correlations of the spin-S Ising models on the square, simple-cubic and body-centered-cubic lattices. On the basis of this large set of data, we confirm accurately the validity of the scaling and universality hypotheses by resuming several tests which involve the correlation function, its moments and the exponential or the second-moment correlation-lengths.Comment: 21 pages, 8 figure

Nonequilibrium Quantum Dynamics Of Disoriented Chiral Condensates

The nonequilibrium dynamics of the chiral phase transition expected during the expansion of the quark-qluon plasma produced in a high energy hadron or heavy ion collision is studied in the O(4) linear sigma model to leading order in a large $N$ expansion. Starting from an approximate equilibrium configuration at an initial proper time $\tau$ in the disordered phase we study the transition to the ordered broken symmetry phase as the system expands and cools. We give results for the proper time evolution of the effective pion mass, the order parameter $$ as well as for the pion two point correlation function expressed in terms of a time dependent phase space number density and pair correlation density. We determine the phase space of initial conditions that lead to instabilities (exponentially growing long wave length modes) as the system evolves in time. These instabilities are what eventually lead to disoriented chiral condensates. In our simulations,we found that instabilities that are formed during the initial phases of the expansion exist for proper times that are at most $3 fm/c$ and lead to condensate regions that do not contain large numbers of particles. The damping of instabilities is a consequence of strong coupling.Comment: 49 pages, figures available by reques

Relationship between nerve fiber layer hemorrhages and outcomes in central retinal vein occlusion

PURPOSE. To evaluate the depth and pattern of retinal hemorrhage in acute central retinal vein occlusion (CRVO) and to correlate these with visual and anatomic outcomes. METHODS. Retinal hemorrhages were evaluated with color fundus photography and fluorescein angiography at baseline and follow-up. Snellen visual acuity (VA), central foveal thickness (CFT), extent of retinal ischemia, and development of neovascularization were analyzed. RESULTS. 108 eyes from 108 patients were evaluated. Mean age was 63.6 ± 16.1 years with a predilection for the right eye (73.1). Average follow-up was 17.2 ± 19.2 months. Mean VA at baseline was 20/126 and 20/80 at final follow-up. Baseline (P = 0.005) and final VA (P = 0.02) in eyes with perivascular nerve fiber layer (NFL) hemorrhages were significantly worse than in eyes with deep hemorrhages alone. Baseline CFT was greater in the group with perivascular hemorrhages (826 ± 394 μm) compared to the group with deep hemorrhages alone (455 ± 273 μm, P < 0.001). The 10 disc areas of retinal ischemia was more common in patients with perivascular (80.0) and peripapillary (31.3) versus deep hemorrhages alone (16.1, P < 0.001). Neovascularization of the iris was more common, although this differrence was not significant, in the groups with peripapillary (14.3) and perivascular (2.0) NFL versus deep hemorrhages alone (0.0). CONCLUSIONS. NFL retinal hemorrhages at baseline correlate with more severe forms of CRVO, with greater macular edema, poorer visual outcomes, and greater risk of ischemia and neovascularization. This may be related to the organization of the retinal capillary plexus. The depth and pattern of distribution of retinal hemorrhages in CRVO may provide an easily identifiable early biomarker of CRVO prognosis. Copyright 2020 The Author

Antibodies against endogenous retroviruses promote lung cancer immunotherapy

B cells are frequently found in the margins of solid tumours as organized follicles in ectopic lymphoid organs called tertiary lymphoid structures (TLS)1,2. Although TLS have been found to correlate with improved patient survival and response to immune checkpoint blockade (ICB), the underlying mechanisms of this association remain elusive1,2. Here we investigate lung-resident B cell responses in patients from the TRACERx 421 (Tracking Non-Small-Cell Lung Cancer Evolution Through Therapy) and other lung cancer cohorts, and in a recently established immunogenic mouse model for lung adenocarcinoma3. We find that both human and mouse lung adenocarcinomas elicit local germinal centre responses and tumour-binding antibodies, and further identify endogenous retrovirus (ERV) envelope glycoproteins as a dominant anti-tumour antibody target. ERV-targeting B cell responses are amplified by ICB in both humans and mice, and by targeted inhibition of KRAS(G12C) in the mouse model. ERV-reactive antibodies exert anti-tumour activity that extends survival in the mouse model, and ERV expression predicts the outcome of ICB in human lung adenocarcinoma. Finally, we find that effective immunotherapy in the mouse model requires CXCL13-dependent TLS formation. Conversely, therapeutic CXCL13 treatment potentiates anti-tumour immunity and synergizes with ICB. Our findings provide a possible mechanistic basis for the association of TLS with immunotherapy response

Initial experience of macular translocation in Singapore - One-year results

Annals of the Academy of Medicine Singapore335641-648AAMS

Macular hole surgery without prone positioning

10.1038/sj.eye.6703081Eye228109

Conscious sedation during ophthalmic surgery under local anesthesia

Minerva Anestesiologica754211-21

Knowledge of visual experience during cataract surgery under local anaesthesia: A nationwide survey of UK ophthalmologists

10.1136/bjo.2006.097030British Journal of Ophthalmology934510-51

A survey on the knowledge and attitudes of anaesthesia providers in the United States of America, United Kingdom and Singapore on visual experiences during cataract surgery

10.1017/S0265021506000093European Journal of Anaesthesiology234276-28

Optimising the management of choroidal neovascularisation in Asian patients: consensus on treatment recommendations for anti-VEGF therapy

Singapore Medical Journal524232-240SIMJ