SAR-Based Vibration Estimation Using the Discrete Fractional Fourier Transform

A vibration estimation method for synthetic aperture radar (SAR) is presented based on a novel application of the discrete fractional Fourier transform (DFRFT). Small vibrations of ground targets introduce phase modulation in the SAR returned signals. With standard preprocessing of the returned signals, followed by the application of the DFRFT, the time-varying accelerations, frequencies, and displacements associated with vibrating objects can be extracted by successively estimating the quasi-instantaneous chirp rate in the phase-modulated signal in each subaperture. The performance of the proposed method is investigated quantitatively, and the measurable vibration frequencies and displacements are determined. Simulation results show that the proposed method can successfully estimate a two-component vibration at practical signal-to-noise levels. Two airborne experiments were also conducted using the Lynx SAR system in conjunction with vibrating ground test targets. The experiments demonstrated the correct estimation of a 1-Hz vibration with an amplitude of 1.5 cm and a 5-Hz vibration with an amplitude of 1.5 mm

Size-resolved aerosol and cloud condensation nuclei (CCN) properties in the remote marine South China Sea - Part 1: Observations and source classification

Abstract. Ship-based measurements of aerosol and cloud condensation nuclei (CCN) properties are presented for 2 weeks of observations in remote marine regions of the South China Sea/East Sea during the southwestern monsoon (SWM) season. Smoke from extensive biomass burning throughout the Maritime Continent advected into this region during the SWM, where it was mixed with anthropogenic continental pollution and emissions from heavy shipping activities. Eight aerosol types were identified using a k-means cluster analysis with data from a size-resolved CCN characterization system. Interpretation of the clusters was supplemented by additional onboard aerosol and meteorological measurements, satellite, and model products for the region. A typical bimodal marine boundary layer background aerosol population was identified and observed mixing with accumulation mode aerosol from other sources, primarily smoke from fires in Borneo and Sumatra. Hygroscopicity was assessed using the κ parameter and was found to average 0.40 for samples dominated by aged accumulation mode smoke; 0.65 for accumulation mode marine aerosol; 0.60 in an anthropogenic aerosol plume; and 0.22 during a short period that was characterized by elevated levels of volatile organic compounds not associated with biomass burning impacts. As a special subset of the background marine aerosol, clean air masses substantially scrubbed of particles were observed following heavy precipitation or the passage of squall lines, with changes in observed aerosol properties occurring on the order of minutes. Average CN number concentrations, size distributions, and κ values are reported for each population type, along with CCN number concentrations for particles that activated at supersaturations between 0.14 and 0.85 %

CP violating asymmetries in single top quark production at the Tevatron p pbar collider

Analytic expressions for the angular distributions of the $b$-quarks associated with single $t$-quark production in $p \bar p \to W^* \to t \bar b \to b \bar b W$ and of the leptons from the subsequent decay $W \to l\nu$ are obtained in the laboratory system. CP violation in the $t$-production vertex is assumed. Different angular and total cross section CP violating asymmetries are considered. Relations testing CP violation solely in the $t$-decay vertex are also obtained. A numerical analysis is performed in the MSSM with a CP violating phase of the trilinear coupling $A_{\tilde t}$. The asymmetries are typically of the order $10^{-3}$ - $10^{-4}$.Comment: The numerical results are corrected and some changes that meet the requirements of Phys. Rev. D are mad

JC Virus infected choroid plexus epithelial cells produce extracellular vesicles that infect glial cells independently of the virus attachment receptor

The human polyomavirus, JCPyV, is the causative agent of progressive multifocal leukoencephalopathy (PML) in immunosuppressed and immunomodulated patients. Initial infection with JCPyV is common and the virus establishes a long-term persistent infection in the urogenital system of 50-70% of the human population worldwide. A major gap in the field is that we do not know how the virus traffics from the periphery to the brain to cause disease. Our recent discovery that human choroid plexus epithelial cells are fully susceptible to virus infection together with reports of JCPyV infection of choroid plexus in vivo has led us to hypothesize that the choroid plexus plays a fundamental role in this process. The choroid plexus is known to relay information between the blood and the brain by the release of extracellular vesicles. This is particularly important because human macroglia (oligodendrocytes and astrocytes), the major targets of virus infection in the central nervous system (CNS), do not express the known attachment receptors for the virus and do not bind virus in human tissue sections. In this report we show that JCPyV infected choroid plexus epithelial cells produce extracellular vesicles that contain JCPyV and readily transmit the infection to human glial cells. Transmission of the virus by extracellular vesicles is independent of the known virus attachment receptors and is not neutralized by antisera directed at the virus. We also show that extracellular vesicles containing virus are taken into target glial cells by both clathrin dependent endocytosis and macropinocytosis. Our data support the hypothesis that the choroid plexus plays a fundamental role in the dissemination of virus to brain parenchyma

CP-violating asymmetries in top-quark production and decay in e+e−e^+ e^- annihilation within the MSSM

We obtain analytic formulae for the cross section of the sequential processes of $e^+ e^- \to t \bar t$ and $t \to b l \nu$ in the laboratory frame where the dependence on triple product correlations of the type (\hat(q}_1 x \hat{q}_2 . \hat{q}_3), induced by CP violation both in the production and the decay are explicitely shown. Different observables sensitive to CP violation are defined and calculated in the Minimal Supersymmetric Standard Model (MSSM). The observables sensitive to CP violation are of the order of $10^-3$. The dependence on the masses of the supersymmetric particles is also shown.Comment: 17 pages of LateX plus five uuencoded Postscript figures, LateX file and PS-figures are also available via anonymous ftp at ftp://info.oeaw.ac.at/pub/hephy-pub/62

Reduction of Vibration-Induced Artifacts in Synthetic Aperture Radar Imagery

Target vibrations introduce nonstationary phase modulation, which is termed the micro-Doppler effect, into returned synthetic aperture radar (SAR) signals. This causes artifacts, or ghost targets, which appear near vibrating targets in reconstructed SAR images. Recently, a vibration estimation method based on the discrete fractional Fourier transform (DFrFT) has been developed. This method is capable of estimating the instantaneous vibration accelerations and vibration frequencies. In this paper, a deghosting method for vibrating targets in SAR images is proposed. For single-component vibrations, this method first exploits the estimation results provided by the DFrFT-based vibration estimation method to reconstruct the instantaneous vibration displacements. A reference signal, whose phase is modulated by the estimated vibration displacements, is then synthesized to compensate for the vibration-induced phase modulation in returned SAR signals before forming the SAR image. The performance of the proposed method with respect to the signal-to-noise and signalto-clutter ratios is analyzed using simulations. Experimental results using the Lynx SAR system show a substantial reduction in ghosting caused by a 1.5-cm 0.8-Hz target vibration in a true SAR image

\u3cem\u3eTrichodysplasia Spinulosa\u3c/em\u3e-Associated Polyomavirus Uses a Displaced Binding Site on VP1 to Engage Sialylated Glycolipids

Trichodysplasia spinulosa-associated Polyomavirus (TSPyV) was isolated from a patient suffering from trichodysplasia spinulosa, a skin disease that can appear in severely immunocompromised patients. While TSPyV is one of the five members of the polyomavirus family that are directly linked to a human disease, details about molecular recognition events, the viral entry pathway, and intracellular trafficking events during TSPyV infection remain unknown. Here we have used a structure-function approach to shed light on the first steps of TSPyV infection. We established by cell binding and pseudovirus infection studies that TSPyV interacts with sialic acids during attachment and/or entry. Subsequently, we solved high-resolution X-ray structures of the major capsid protein VP1 of TSPyV in complex with three different glycans, the branched GM1 glycan, and the linear trisaccharides α2,3- and α2,6-sialyllactose. The terminal sialic acid of all three glycans is engaged in a unique binding site on TSPyV VP1, which is positioned about 18 Å from established sialic acid binding sites of other polyomaviruses. Structure-based mutagenesis of sialic acid-binding residues leads to reduction in cell attachment and pseudovirus infection, demonstrating the physiological relevance of the TSPyV VP1-glycan interaction. Furthermore, treatments of cells with inhibitors of N-, O-linked glycosylation, and glycosphingolipid synthesis suggest that glycolipids play an important role during TSPyV infection. Our findings elucidate the first molecular recognition events of cellular infection with TSPyV and demonstrate that receptor recognition by polyomaviruses is highly variable not only in interactions with sialic acid itself, but also in the location of the binding site

JC Polyomavirus Uses Extracellular Vesicles To Infect Target Cells

The endemic human JC polyomavirus (JCPyV) causes progressive multifocal leukoencephalopathy in immune-suppressed patients. The mechanisms of virus infection in vivo are not understood because the major target cells for virus in the brain do not express virus receptors and do not bind virus. We found that JCPyV associates with extracellular vesicles (EVs) and can infect target cells independently of virus receptors. Virus particles were found packaged inside extracellular vesicles and attached to the outer side of vesicles. Anti-JCPyV antisera reduced infection by purified virus but had no effect on infection by EV-associated virus. Treatment of cells with the receptor-destroying enzyme neuraminidase inhibited infection with purified virus but did not inhibit infection by EV-associated virus. Mutant pseudoviruses defective in sialic acid receptor binding could not transduce cells as purified pseudovirions but could do so when associated with EVs. This alternative mechanism of infection likely plays a critical role in the dissemination and spread of JCPyV both to and within the central nervous system

Spectroscopy of Broad Line Blazars from 1LAC

We report on optical spectroscopy of 165 Flat Spectrum Radio Quasars (FSRQs) in the Fermi 1LAC sample, which have helped allow a nearly complete study of this population. Fermi FSRQ show significant evidence for non-thermal emission even in the optical; the degree depends on the gamma-ray hardness. They also have smaller virial estimates of hole mass than the optical quasar sample. This appears to be largely due to a preferred (axial) view of the gamma-ray FSRQ and non-isotropic (H/R ~ 0.4) distribution of broad-line velocities. Even after correction for this bias, the Fermi FSRQ show higher mean Eddington ratios than the optical population. A comparison of optical spectral properties with Owens Valley Radio Observatory radio flare activity shows no strong correlation.Comment: Accepted for publication in Ap