Parent Interaction In Primetime Family Themed Television Portrayals: A Replication And Extension Of Dail And Way\u27s (1985) Content Analysis

This research is a replication and extension of Dail and Way’s (1985) content analysis identifying parent interactions portrayed in family oriented prime time network television programs. Family structure, parent role, child rearing, and child responses were coded from five episodes each of eight different programs from 2014-2015 television season. The programs presented parent roles more often than child rearing, while mothers were found in child rearing more often than fathers. Traditional family structures were most prevalent with fewer single parent households and a new presence of same-sex parents. Mothers and fathers were still portrayed stereotypically, but children’s responses were more realistic and further reinforced traditional gender roles. Child responses reinforced traditional and rejected non-traditional parent interactions according to the parents’ sex, partnership, and occupation

The vaulting system of the Palatine Chapel: the Aachen Cathedral world heritage site documentation project.

As part of a comprehensive survey and modelling project involving the Aachen Cathedral, this paper focuses on its oldest part, the Palatine Chapel, a domed octagonal hall supported by eight piers and enveloped by a sixteen-sided outer wall. Working on the data collected during an extensive 3D capturing campaign conducted between 2022 and 2023, this paper will focus on the conic vaults covering the ambulacrum of the 1st floor that represent quite a peculiar architectural and structural solution considering the VIII/IX century building know-how. In this framework, the Chapel's 3D point cloud has been analysed to extract the main 2D generative elements of the conic surfaces and then construct the corresponding 3D geometric models. These outputs have been compared against the captured point cloud to assess the differences between the actual vault data and the reconstructed ideal conic shapes. Finally, the method used to unfold the vaults' surfaces and create high-resolution ortho-images has been displayed

EVOLUTION OF RECORDING METHODS: THE AACHEN CATHEDRAL WORLD HERITAGE SITE DOCUMENTATION PROJECT

Modern terrestrial laser scanners and photogrammetric imaging systems can provide highly accurate and objective as-built records of existing architectural, engineering, and industrial sites. This comprehensive digital recording benefits culturally significant places like heritage buildings, monuments, and other vital structures. The collected data can be instrumental in various ways, including aiding in conservation, management, monitoring and repair efforts and serving as an educational resource for scholars and the general public. These technical capabilities are especially well-suited for architecturally complex, ornate buildings like the Aachen Cathedral UNESCO World Heritage site. This paper describes the recent recording efforts at the Aachen Cathedral and is a comparative study of the previous documentation work done at the Cologne Cathedral.The 3D documentation of the Aachen Cathedral UNESCO World Heritage Site is an ongoing collaborative project between the Sapienza Università di Roma, Rome, Italy, Robert Gordon University, Aberdeen, Scotland, and in partnership with RWTH Aachen University, and the Dombauhütte Aachen.</p

2-(2-thienyl)-5,6-dihydroxy-4-carboxypyrimidines as inhibitors of the hepatitis C virus NS5B polymerase: Discovery, SAR, modeling, and mutagenesis

Infections caused by hepatitis C virus (HCV) are a significant world health problem for which novel therapies are in urgent demand. The polymerase of HCV is responsible for the replication of viral RNA. We recently disclosed dihydroxypyrimidine carboxylates 2 as novel, reversible inhibitors of the HCV NS5B polymerase. This series was further developed into 5,6-dihydroxy-2-(2- thienyl)pyrimidine-4-carboxylic acids such as 34 (EC50 9.3 \u3bcM), which now show activity in the cell-based HCV replication assay. The structure-activity relationship of these inhibitors is discussed in the context of their physicochemical properties and of the polymerase crystal structure. We also report the results of mutagenesis experiments which support the proposed binding model, which involves pyrophosphate-like chelation of the active site Mg ions

Identification and biological evaluation of a series of 1H-benzo[de]isoquinoline-1,3(2H)-diones as hepatitis C virus NS5B polymerase inhibitors

The hepatitis C virus (HCV) NS5B RNA-dependent RNA polymerase (RdRp) plays a central role in virus replication. NS5B has no functional equivalent in mammalian cells and, as a consequence, is an attractive target for inhibition. Herein, we present 1H-benzo[de]isoquinoline-1,3(2H)-diones as a new series of selective inhibitors of HCV NS5B polymerase. The HTS hit 1 shows submicromolar potency in two differentHCVreplicons (1b and 2b) and displays no activity on other polymerases (HIV-RT, Poliopol, GBV-b-pol). These inhibitors act during the pre-elongation phase by binding to NS5B non-nucleoside binding site Thumb Site II as demonstrated by crystal structure of compound 1 with the \u394C55-1b and \u394C21-2b enzymes and by mutagenesis studies. SAR in this new series reveals inhibitors, such as 20, with low micromolar activity in the HCV replicon and with good activity/toxicity window in cells