Application of Classical Versus Bayesian Statistical Methods to On-line Radiological Monitoring

The on-line monitoring for illicit radioactive material with a minimum number of false detections is a critical need for homeland security. The primary objectives of this work were to apply both Bayesian and classical statistical process control chart techniques to the on-line monitoring of radiological data and to then compare the Type I and Type II error incidence rates. Two versions of the cumulative sum (CUSUM) and Shiryayev-Roberts (S-R) procedures known as total reset and alarm reset methods were developed. The best method in terms of Type I errors was the S-R total reset method. In terms of Type II errors, the CUSUM alarm reset procedure and the S-R alarm reset control scheme were most effective. At high count rates, the Shewhart (3-sigma) control chart resulted in the fewest number of false negatives independent of the amount of time a source was present

Stranger Here, Myself

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IMPACT: Pedagogical Leadership

Presented to Corporate Partners of the Dept. of Computer Science, Purdue University, West Lafayette, IN. Gives overview of Instruction Matters Purdue Academic Course Transformation (IMPACT), including the suite of technologies, faculty involvement, and statistics indicating numbers of transformed courses. Concludes with discussion of funding and future of IMPACT

Stylistic markers of “serious relief” in Wilde s Lord Arthur Savile s Crime

Autor w strukturze opowiadania O. Wilde'a wyróżnia części o reliefie serio i reliefie komicznym. Poddaje analizie fragment - dość wyjątkowy w opowiadaniu - w którym elementów humoru jest bardzo mało. Brak humoruu stanowi tu wynik celowego zamiaru Wilde'a i został uzyskany m.in. poprzez użycie określonych przymiotników, innych niż w innych partiach opowiadania

IMPACT: Customized Faculty Development for Learner-Centered Course Redesign

IMPACT at Purdue University works with instructors to redesign large-enrollment, foundational courses with the aim of engaging students more fully in their learning and creating a more student-centered environment, with the expectation that this will improve student success. IMPACT faculty are guided through a semester-long course of FLC (Faculty Learning Community) sessions based on IMPACT\u27s design model. Faculty also work with a small support team that provides guidance and expertise in the areas of educational technology, instructional design, information literacy, and learning assessment. Year-three program and course assessment measures and results will be discussed. Outcomes: Discuss IMPACT\u27s program of support for faculty in creating student-centered, active learning * List the program and course assessments used by the IMPACT program * Formulate useful takeaways for your institution\u27s faculty development program

Novel in vivo imaging approaches to study embryonic and adult neurogenesis in the mouse

Neurogenesis is the process of generation of neurons during embryonic development and adulthood. The focus of this doctoral work is the study of the cell biological aspects of neurogenesis and the mechanisms regulating the switch of neural stem cells from proliferation to differentiation. During embryonic development neurogenic divisions occur at the apical or basal side of the pseudostratified epithelium that forms the wall of the neural tube, the neuroepithelium. Apical asymmetric neurogenic divisions (AP) give rise to a neuron and a progenitor cell, while basal symmetric neurogenic divisions (BP) give rise to two neurons. The first part of this thesis is focused on the study of some cell biological aspects of BPs. We first validated the use of the Tis21-GFP knock in mouse line, previously generated in our laboratory. We found that the totality of neurogenic progenitors is marked by the expression of a nuclear GFP. We calculated the abundance of BPs overtime since the onset of neurogenesis showing that BPs overcome APs over development. We studied the loss of apical contact of the basal dividing cells. We found that both neurogenic and non-neurogenic basally dividing progenitors miss the apical contact; which is lost prior mitosis. We generated and characterized a second mouse line, the Tubb3-GFP line expressing a plasma membrane-localized GFP in neurons. These two lines were crossed to obtain a new line (TisTubb-GFP) allowing detection of neurogenic divisions and tracking daughter cells. Using this model: (i) we imaged symmetric neurogenic divisions of BPs, identifying daughter cells as neurons, during imaging; (ii) we compared the kinetics of betaIII-tubulin-GFP appearance after apical or basal mitosis, showing that daughters of BPs express betaIII-tubulin-GFP faster than daughters coming from apical divisions; (iii) we imaged neuronal migration and localization of the Golgi apparatus. Neurogenesis in the adult is confined to two specific regions in the telencephalon: the sub ependymal zone, lining the ventricle, and dentate gyrus of the hippocampus. The second part of this thesis focuses on the adult neurogenic progenitors lineage. Tis21-GFP expression was found and characterized in the two adult neurogenic regions from early postnatal to adulthood. Using a panel of markers for the adult neurogenic cell lineage and confocal imaging, we characterized Tis21-GFP expression, in the dentate gyrus. Tis21-GFP is first expressed in the neurogenic subpopulation of doublecortin positive cells. Tis21-GFP is inherited by the neurons and eventually degraded. Moreover, our data suggest that mitotic Tis21-GFP cells are an indicator of the levels of neurogenesis more accurate than doublecortin positive cells, in the early postnatal mouse. (Anlage Quick time movies 77,88 MB

Three Questions About The Shape of Silence

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Minority Stress, Same-Sex Couples, and Marriage Equality: A Qualitative Interview Study

In June 2015, the marriage equality movement in the United States succeeded at the federal level. This study documents individuals’ perceptions of how the fight for marriage equality affected their thoughts, feelings, and behaviors within their own marriages to same-sex spouses. I conducted interviews with eight married individuals (five men and three women) who were married prior to the Supreme Court decision legalizing same-sex marriage nationwide. Areas of inquiry included (a) motivation to get married, (b) factors affecting commitment, (c) willingness to utilize couple therapy, and (d) factors affecting thoughts about divorce. I hypothesized that, for some individuals or couples, the fight to legalize same-sex marriage nationwide may have imposed pressure to promote the cause of marriage equality or fight antigay stigma and prejudice, thereby affecting commitment in their marriage. The primary interest in this study was to better understand the way individuals think about their marriages and how they were affected by the marriage equality movement. I used interpretive phenomenological analysis to analyze the data. Most participants endorsed some degree of political or social justice themes in their reasons for getting married or among the factors impacting their thoughts and feelings about marriage. Fewer participants thought political and social justice concerns would impact their commitment or thoughts about divorce, though this was a factor for two individuals. Participants did not see their willingness to use couple therapy as impacted by the marriage equality movement or by political and social justice concerns. Participants also described the impact of the marriage equality movement and the associated sociocultural/political turmoil on their lives in general. This study has implications for therapists working with same-sex couples or individuals struggling with relationship concerns. Political factors can be present among the motivations of a couple to get married. For some individuals, it is possible these factors impact commitment, though in this study, this was only true for two interviewees. If therapists are aware of the impact of their clients’ political and social justice concerns on their values and their relationships, they will be more likely to form accurate case conceptualizations and targeted interventions to help clients work through their problems

Four-way regulation of mosquito yolk protein precursor genes by juvenile hormone-, ecdysone-, nutrient-, and insulin-like peptide signaling pathways.

Anautogenous mosquito females require a meal of vertebrate blood in order to initiate the production of yolk protein precursors by the fat body. Yolk protein precursor gene expression is tightly repressed in a state-of-arrest before blood meal-related signals activate it and expression levels rise rapidly. The best understood example of yolk protein precursor gene regulation is the vitellogenin-A gene (vg) of the yellow fever mosquito Aedes aegypti. Vg-A is regulated by (1) juvenile hormone signaling, (2) the ecdysone-signaling cascade, (3) the nutrient sensitive target-of-rapamycin signaling pathway, and (4) the insulin-like peptide (ILP) signaling pathway. A plethora of new studies have refined our understanding of the regulation of yolk protein precursor genes since the last review on this topic in 2005 (Attardo et al., 2005). This review summarizes the role of these four signaling pathways in the regulation of vg-A and focuses upon new findings regarding the interplay between them on an organismal level