Nanovesicles for tumor-targeted drug delivery

Cancer is one of the most important burdens for the health systems worldwide due to cancer-related deaths associated with late diagnosis and treatment toxicities. Diagnosis of cancer plays a critical role in reducing cancer death rates as it facilitates early prognosis and treatment. Current cancer treatment mainly includes the resection of tumor tissue, radiation treatment, and pharmaceutical treatment. Although various techniques, methods, and drugs are clinically used in cancer diagnosis and treatment, they are inadequate for early diagnosis and effective treatment. Therefore, several studies regarding cancer-targeted nanosized drug delivery systems and theranostic approach are performed. Nanovesicular systems, one of the most important types of drug delivery systems, are formulated for the effective delivery and controlled release of active compounds such as drugs, genes, phytocompounds, and imaging agents. In this chapter, different types of nanovesicles are reviewed after providing information about conventional cancer imaging and treatment. Furthermore, targeting mechanisms of nanovesicles for cancer are explained. Finally, some studies performed to develop the nanovesicles as the imaging, treatment, or theranostic system for cancer are summarized. © 2022 Elsevier Inc. All rights reserved

Recent developments in cancer therapy and diagnosis

Background: The cancer is serious health problem and leading cause of death in the world. Area covered: There have intensively studied for diagnosis and therapy of this disease and these studies provided important insights into their mechanism of action and therapeutic/diagnostic effects. The accurence rates of cancer has dramatic increase, particularly in the developed countries. Although there are many different strategies about diagnosis and treatment for cancer, more effective new approaches are needed. Expert opinion: In this review, we summarize recent developments on cancer diagnosis, radiopharmaceuticals in cancer diagnosis, nanoparticulate systems in cancer diagnosis, T cells in cancer diagnosis, cancer therapy and pharmacokinetic of anticancer drugs. We thought that while there are some current limitations such as clinical studies, ranging from diagnosis to theraphy, future improvements in cancer diagnosis and treatment will meet the most relevant issues required for the eventual approval of nano-drugs, radiopharmaceuticals, T cells in clinical practice. © 2020, The Korean Society of Pharmaceutical Sciences and Technology