Upaya Meningkatkan Pembelajaran Tolak Peluru Gaya Ortodok's dengan Media Modifikasi Bola Kasti di Sdn

About problem which is worked through in this research is how learning ability step-up shot put inspire orthodox with utilizing kasti's ball media on country elementary school 23 Regency Mangrove Capes Sambas. To the effect this research is subject to be know to mark sense learning ability step-up shot put inspires orthodox by use of kasti's ball media on student brazes v SDN 23 Regency Mangrove Capes Sambas. Research is done with this observational method is Observational Action. Population in observational it is Country Elementary School student 23 Regency Mangrove Capes Sambas as much 41 students, sample take utilizes to methodic total sampling, with the meaning taking sample by taken all, with sample amount 41 students. This observational tech utilizes to essay Shot Put performing process Orthodox Style which is estimation on aspect in do Shot Put Learning movement Orthodox Style. Analisis is data utilizes presentase's formula. This observational result menunjukan Implement Methodics Kasti's Ball Media evident can increase Shot Put Learning ability Orthodox Style

Peningkatan Pembelajaran Lompat Jauh melalui Media Alat Peraga di Min

: About problem in this research is athletic learning in particular broadjump number inspires problem found squat, where is still a lot of student that itspoint (learned result) haven\u27t accomplished KKM. To the effect of observational itis know result step-up studies broad jump via approaching plays on student brazes5 at madrasah ibtidaiyah mangrove river country goes out to sea Pontianak\u27sRegency. Method that is utilized in this research is Observational Action braze(PTK) by use of two cycles. subjek is research is exhaustive student brazes 5 atmadrasah ibtidaiyah mangrove river country goes out to sea Pontianak\u27s Regencythat consisting of 27 students with female composition as much 13 student andmale as much 14 students. Base observational data already dianalisi, thoroughnesspercentage studies result essays on prasiklus which is 33%, enter on i. cycle as70% and increasing on cycle II. as 100%. This points out all student that followcomplete learning in yielding its studying

Pengaruh Media Pembelajaran Melompat Terhadap Hasil Belajar Tehnik Dasar Lompat Jangkit Di SMA

The purpose of this study was to determine the effect of instructionalmedia jump on learning outcomes basic technique triple jump in class XA SMAN3 Ketapang district of West Borneo Province. The method used was experimental.Shape design of experiments using Pre-Experimental Design. The samples in thisstudy using purposive sampling technique with a number of 30 people. Dataanalysis was performed by t-test analysis. From the results of the test are triplejump thitung > ttabel (14.85 > 2.045) it can be concluded that the hypothesis isaccepted, which means that there is an influence. There is a change in the testtriple jump increase by 30%. It is based on the results of tests triple jump aftertreated (treatment), where the mean is greater than the mean posttest pretest(18,6>14.3), Therefore, the application of instructional media vault with a tool ormaterial PVC and rubber stretched can be applied to learning the basic techniquetriple jump

Driving Cycle Analysis for Fuel Economy and Emissions in Kuala Terengganu during Peak Time

Number of vehicles grows rapidly in Kuala Terengganu by year. This increment is troubled by the performance of the vehicle regarding pollutants generated. Plug-in hybrid electric vehicles (PHEV) are widely considered to be the most promising vehicles instead of the traditional engine vehicles to reduce fuel consumption and exhaust gas emission. The objectives of this paper are to develop driving cycle of Kuala Terengganu and to analyse the fuel economy and emissions in Kuala Terengganu during peak time. Driving cycle is where PHEV is used as the main apparatus to determine the driving cycle data. In this study, the on-road measurement method is used to collect the data, along with the global positioning system. This technique involves recording speedtime dataset in the real-world driving cycle. Three main methods to identify the best driving cycle are route selection, data collection and data analysis. The data were analysed to get the best driving cycle using a computer program, which is Mathematical Laboratory (MATLAB), along with validated parameters

Social participation is reduced in type 3 Von Willebrand disease patients and in patients with a severe bleeding phenotype

Introduction The negative impact of haemophilia on social participation is well established in previous studies, however, the impact of Von Willebrand disease (VWD) on social participation has not been studied. Aim To compare the social participation of a large cohort of VWD patients in the Netherlands with the general Dutch population. In addition, to identify factors associated with social participation in VWD. Methods Patients participating in the "Willebrand in the Netherlands" study completed an extensive questionnaire on educational level, absenteeism from school or work, and occupational disabilities. Results Seven-hundred and eighty-eight VWD patients were included (mean age 38.9 years, 59.5% females), of whom 136 children = 16 years the days lost from school and/or work in the year prior to study inclusion differed significantly between the VWD types (p = .011). Using negative binomial regression analysis, the occurrence of bleeding episodes requiring treatment in the year preceding study inclusion was significantly associated with the number of days lost from school and/or work among patients aged >= 16 years. Multivariable logistic regression analysis showed that a higher total bleeding score, older age and presence of at least one comorbidity were significantly associated with occupational disability in patients aged >= 16 years. Conclusion Our study shows that social participation was lower in type 3 VWD and VWD patients with a more severe bleeding phenotype

Von Willebrand Factor Multimer Densitometric Analysis:Validation of the Clinical Accuracy and Clinical Implications in Von Willebrand Disease

Von Willebrand factor (VWF) multimer analysis is important in the classification of von Willebrand disease (VWD). Current visual VWF multimer analysis is time consuming and inaccurate in detecting subtle changes in multimer patterns. Although VWF multimer densitometric analysis may be useful, the accuracy needs further investigation before it can be widely applied. In this study we aimed to validate VWF multimer densitometric analysis in a large cohort of VWD patients and to identify patient characteristics associated with densitometric outcomes. Patients were included from the Willebrand in the Netherlands (WiN) study, in which a bleeding score (BS) was obtained, and blood was drawn. For multimer analysis, citrated blood was separated on an agarose gel and visualized by Western blotting. IMAGEJ was used to generate densitometric images and medium-large VWF multimer index was calculated. We included 560 VWD patients: 328 type 1, 211 type 2, and 21 type 3 patients. Medium-large VWF multimer index performed excellent in distinguishing visually classified normal VWF multimers from reduced high-molecular-weight (HMW) multimers (area under the curve [AUC]: 0.96 [0.94-0.98], P < 0.001), normal multimers from absence of HMW multimers (AUC 1.00 [1.00-1.00], P < 0.001), and type 2A and 2B from type 2M and 2N (AUC: 0.96 [0.94-0.99], P < 0.001). Additionally, higher medium-large VWF multimer index was associated with lower BS in type 1 VWD: beta = -7.6 (-13.0 to -2.1), P = 0.007, adjusted for confounders. Densitometric analysis of VWF multimers had an excellent accuracy compared with visual multimer analysis and may contribute to a better understanding of the clinical features such as the bleeding phenotype of VWD patients

Platelet degranulation and bleeding phenotype in a large cohort of Von Willebrand disease patients

Von Willebrand disease (VWD) is a bleeding disorder caused by quantitative (type 1 or 3) or qualitative (type 2A/2B/2M/2N) defects of circulating von Willebrand factor (VWF). Circulating VWF levels not always fully explain bleeding phenotypes, suggesting a role for alternative factors, like platelets. Here, we investigated platelet factor 4 (PF4) in a large cohort of patients with VWD. PF4 levels were lower in type 2B and current bleeding phenotype was significantly associated with higher PF4 levels, particularly in type 1 VWD. Based on our findings we speculate that platelet degranulation and cargo release may play a role across VWD subtypes

Importance of Genotyping in von Willebrand Disease to Elucidate Pathogenic Mechanisms and Variability in Phenotype

Genotyping is not routinely performed at diagnosis of von Willebrand disease (VWD). Therefore, the association between genetic variants and pathogenic mechanism or the clinical and laboratory phenotype is unknown in most patients, especially in type 1 VWD. To investigate whether genotyping adds to a better understanding of the pathogenic mechanisms and variability in phenotype, we analyzed the VWF gene in 390 well-defined VWD patients, included in the WiN study. A VWF gene variant was found in 155 patients (61.5%) with type 1, 122 patients (98.4%) with type 2, and 14 patients (100%) with type 3 VWD. Forty-eight variants were novel. For each VWF gene variant, the pathogenic mechanisms associated with reduced VWF levels was investigated using the FVIII:C/VWF:Ag and VWFpp/VWF:Ag ratios. In type 1 VWD, reduced synthesis or secretion of VWF was most frequently found in patients with nonsense variants, frameshift variants, and deletions, whereas rapid clearance of VWF was mainly found in patients with missense variants. Furthermore, type 1 VWD patients with and without a VWF gene variant were clearly distinct in their clinical features such as age of diagnosis, laboratory phenotype, and bleeding phenotype. In type 2 VWD, 81% of variants were associated with an increased clearance of VWF. To conclude, we identified the pathogenic mechanisms associated with various VWF gene variants in type 1, 2, and 3 VWD patients. Additionally, major differences in the phenotype of type 1 VWD patients with and without a variant were observed, which may be of importance for clinical management

Major differences in clinical presentation, diagnosis and management of men and women with autosomal inherited bleeding disorders

Background: In recent years, more awareness is raised about sex-specific dilemmas in inherited bleeding disorders. However, no large studies have been performed to assess differences in diagnosis, bleeding phenotype and management of men and women with bleeding disorders. Therefore, we investigated sex differences in a large cohort of well-defined patients with autosomal inherited bleeding disorders (von Willebrand disease (VWD), rare bleeding disorders (RBDs) and congenital platelet defects (CPDs)).Methods: We included patients from three nationwide cross-sectional studies on VWD, RBDs and CPDs in the Netherlands, respectively the WiN, RBiN and TiN study. In all studies a bleeding score (BS) was obtained, and patients filled in an extensive questionnaire on the management and burden of their disorder.Findings: We included 1092 patients (834 VWD; 196 RBD; 62 CPD), of whom 665 (60.9%) were women. Women were more often referred because of a bleeding diathesis than men (47.9% vs 36.6%, p = 0.002). Age of first bleeding was similar between men and women, respectively 8.9 +/- 13.6 (mean +/- sd) years and 10.6 +/- 11.3 years (p = 0.075). However, the diagnostic delay, which was defined as time from first bleeding to diagnosis, was longer in women (11.6 +/- 16.4 years) than men (7.7 +/- 16.6 years, p = 0.002). Similar results were found when patients referred for bleeding were analyzed separately. Of women aging 12 years or older, 469 (77.1%) had received treatment because of sex-specific bleeding.Interpretation: Women with autosomal inherited bleeding disorders are more often referred for bleeding, have a longer diagnostic delay, and often require treatment because of sex-specific bleeding. (C) 2021 The Authors. Published by Elsevier Ltd.Clinical epidemiolog