Is There Any Correlation Between De Ritis Ratio and Prostate Cancer in Males Who Underwent Transrectal Prostate Biopsy?

Objective:This study aims to evaluate the diagnostic value of the De Ritis ratio (DRR) in predicting prostate cancer (PCa) and clinically significant prostate cancer (csPCa) in biopsy-naive patients with suspected PCa.Method:We retrospectively reviewed medical records of 282 male patients who underwent transrectal ultrasound-guided prostate needle biopsy (PNB) between January 2015 and July 2019. Demographic and clinical characteristics of the patients including digital rectal examination findings, preoperative prostate-specific antigene (PSA), aspartate aminotransferase levels, alanine aminotransferase levels, prostate volume, comorbidities and pathological findings of the PNB specimens were noted in detail for each patient. The study cohort was divided into two groups according to the histopathological results of PNB specimens (group 1: patients with benign histopathology, group 2: patients with PCa). The receiver operating characteristic (ROC) curve analysis was conducted to evaluate the diagnostic performance of PSA, PSA density and DRR in predicting PCa.Results:The median age of the participants was 64 (59-69) years. While 71.6% (n=202) of the participants were in group 1, 28.4% (n=80) of them were in group 2. The median DRR value of group 1 was 1.08 (range: 0.89-1.32), and the median DRR value of group 2 was determined as 1.19 (range: 0.95-1.56), and the median DRR value of group 2 was found to be statistically significantly higher than that of group 1 (p=0.013). Statistically significant but a weak positive correlation was observed between PCa in PNB specimens and DRR (r=0.149, p=0.012), while there was no statistically significant correlation between csPCa in PNB specimens and DRR (r=0.002, p=0.983). The ROC curve analysis showed that the cut-off value of DRR for the presence of PCa in PNB specimens was 1.125 and the area under curve was 0.595 (95% confidence interval=0.518-0.672, p=0.013) for the presence of PCa in PNB specimens.Conclusion:This study suggests that DRR had restricted diagnostic importance in predicting PCa in biopsy-naive patients who underwent transrectal PNB

Citation Analysis of the Articles Published in the Bagcilar Medical Bulletin Between December 2016 and June 2020

Objective:To describe publication characteristic and citation analysis of Bagcilar Medical Bulletin (BMB) since its first publication time to January 2020 using bibliometric methods.Method:Researched articles published in the BMB between December 2016 and June 2020 have been analyzed. The journal database was evaluated according to study type (original research, review, case report, letter to the editor), related scientific subspecialty and the geographical origin. We also calculated the rates of citation by dividing the total number of citations received by all papers by the total number of papers.Results:A total of 88 articles were included in the study. The articles about neurosurgery, anesthesia and pediatrics were in the top three (27.27%, 13.63% and 11.36%, respectively). Citation rates of the original article, case report and review were 15.7%, 10.3% and 0%, respectively. Most of the articles (81.81%) were published from Marmara Region in Turkey. Of the articles, 4 (4.5%) were international papers submitted from 2 different countries. All international papers were preclinical subspecialties like pharmacology, microbiology and physiology.Conclusion:Our study provides an opportunity to compare the citation numbers and characteristics before and after indexing of the journal in TUBITAK/ULAKBIM, in near future

Traditional Serrated Adenoma of the Urinary Bladder: The First Report

© The Author(s) 2022.A 71-year-old woman was hospitalized with hematuria and underwent cystourethroscopy. Cystourethroscopy revealed a polypoid bladder tumor. Histopathologic examination showed complex villiform growth pattern, slit-like serrations, and ectopic crypts lined by epithelium with eosinophilic cytoplasm, pseudostratified elongated nuclei, consistent with traditional serrated adenoma. Nephrogenic and intestinal metaplasia with severe inflammation were present in adjacent bladder mucosa. Molecular study of the polyp revealed mutation (p.G12V) in codon 12 of exon 2 of the KRAS gene. Traditional serrated adenoma is a rare type of colonic serrated polyp, making up less than 1% of the colonic polyps with a predilection to distal colon. In the literature, there is no traditional serrated adenoma reported outside the gastrointestinal tract. Here in we report the first extra-gastrointestinal traditional serrated adenoma within the bladder and bladder diverticulum, arising from intestinal metaplasia. The present study reports an additional information on molecular background of this unusual bladder polyp

The anxiolytic effects of testosterone may be modulated by central nervous system androgen receptor activity in gonadectomized male mice

WOS: 000424033100273

Impact of dutasteride on spermatogenesis and oxidative status in rats

Gül, Murat ( Aksaray, Yazar )OBJECTIVES: Although the association between 5 alpha reductase inhibitors used for the treatment of both androgenetic alopecia and benign prostatic hyperplasia and their side effects is well established, the impact of dutasteride on testicular structure is not clear. To evaluate the alterations in spermatogenesis and serum FSH, LH, testosterone and dihydrotestosterone concentrations along with the oxidative status in testes and blood of the rats treated with daily dutasteride. METHODS: A total of 18 male Sprague-Dawley rats have been divided into 2 groups as control (n=8) and dutasteride (n=10). After chronically administered, rats were sacrificed and their testes were harvested for histopathological and biochemical evaluation. Johnsen’s criteria were used to assess spermatogenesis. Serum hormone concentrations and levels of reactive oxygen species (ROS) in both testicular tissue and serum were measured by ECLIA and ELISA, respectively. Results were compared with Mann- Whitney U test. RESULTS: DHT (7.35 ± 0.35 vs. 10.54 ± 0.95, p<0.001) and LH levels (0.32 ± 0.009 vs. 0.43 ± 0.01, <0.001) were significantly lower in treatment group compared with controls whereas testosterone levels were higher in dutasteride arm (3.41 ± 1.12 vs. 1.52 ± 0.34, p<0.001). Johnsen score, serum FSH levels, serum and tissue ROS levels were similar between the two groups. CONCLUSIONS: According to our results, administration of dutasteride does not appear to modify spermatogenesis and oxidative burden in rats. Further investigations are required to confirm our findings