Immunoglobulin G4 related mastitis: A case report

Immunoglobulin (Ig)G4-related sclerosing disease is a recently recognised condition characterised by mass forming lesions associated with storiform fibrosis, obliterative phlebitis, lymphoplasmacytic infiltrate rich in IgG4 positive plasma cells and elevated serum IgG4 levels. IgG4-related mastitis (IgG4-RM) is exceedingly rare with only thirteen cases reported in the literature to date.Immunoglobulin G4-RM is diagnosed exclusively on histological analysis. It is a benign chronic inflammatory process that can be treated sufficiently with excision or steroid. However, conservative treatment should be preferred and unnecessary surgery should be avoided as IgG4-RM respond to simple and effective steroid treatment. Herein, we presented a 28-year-old patient with IgG4-RM. She was the youngest patient in the literature at the time of her diagnosis.C1 [Atigan, Ayhan] Pamukkale Univ, Sch Med, Dept Gynecol & Obstet, Denizli, Turkey.[Ozgen, Utku; Erdem, Ergun] Pamukkale Univ, Sch Med, Dept Gen Surg, Denizli, Turkey.[Demirkan, Nese] Pamukkale Univ, Sch Med, Dept Pf Pathol, Denizli, Turkey

Similar effects of three endurance exercise protocols in women with metabolic syndrome: Interest of moderate-intensity aerobic exercise training with a pedometer

Objectives: The aim of this study was to show the effects of different intensities and durations of aerobic exercise on weight, abdominal obesity, metabolic, and hormonal responses in women with metabolic syndrome (MetS). Equipment and methods: Sixty women with MetS were randomly assigned to one of the three training groups: high-intensity exercise group (HIE) (n = 20), moderate-intensity exercise group (MIE) (n = 20) and moderate-intensity pedometer group (ECE PEDO) (n = 20). HIE group exercised 20 minutes a day, 3 days a week at %70 VO2max, while MIE and ECE PEDO groups exercised 5 days a week, 30 minutes a day at %50 VO2max. The primary outcome measures were anthropometric measurements including abdominal fat, VO2max measurements, lipid profile, adrenaline, noradrenaline, free fatty acids (FFA), glycerol, and oxyntomodulin parameter. Results: A total of 51 women completed the 12-week exercise program. Anthropometric measurements such as weight, BMI, waist circumference (WC), visceral fat (VF) and trunk fat percentage were all decreased significantly at week 12 in all groups (P < 0.017). The median VF was decreased from 17 (14.9–20.05) to 15.1 (11.2–16.75), from 17.75 (15.5–21.87) to 16.65 (13.9–20.9) and from 18.5 (17.5–20.45) to 16.65 (15.25–18.5) for HIE, MIE and ECE PEDO groups respectively at 12th week (P < 0.017). The median oxyntomodulin increased from 61.65 (48.32–70.50) to 120.11 (63.37–157.35) only in MIE group (P < 0.017). No significant differences were seen between the groups for all outcome measures (P > 0.05). Conclusion: Moderate aerobic exercises performed 5 days a week as supervised treadmill exercise or home-based pedometer walking were not significantly different from high-intensity supervised treadmill exercise made 3 days a week for weight, VF, exercise capacity and metabolic parameters in women with MetS. Increasing oxyntomodulin levels with moderate-intensity exercise may have beneficial metabolic effects in patients with MetS. ClinicalTrials.gov identifier number: NCT03445741. © 2020 Elsevier Masson SA

value in primary HPV screening?

Objective: This study aimed to determine the factors associated with Human Papillomavirus (HPV) persistence in women undergoing cervical excision for pre-invasive lesions, after they have been referred from a primary HPV screening program.Methods: A retrospective study design involving patients who were treated at a Cervical Disease Screening and Treatment Unit, in a university hospital setting. After initial treatment, cervical HPV infection status was analyzed at the sixth month, first year and then subsequently after the second year.Results: Totally, 395 patients who were diagnosed with pre-invasive cervical lesions and who subsequently undergone cervical excision were identified. In the first-year visit after cervical excision, HPV 18 was cleared in almost all (95.8%) cases, followed by HPV 16 (69.9%) and other hrHPV types (65.6%). Available data documented that 88.6% of women reached clearance after the two-year follow-up. Univariate analysis revealed a significantly higher proportion of HPV clearance among women who were younger (p = 0.019), premenopausal (p = 0.002), and who had been found to have a negative cytology result on their initial Pap test (p = 0.018). However, only cervical cytology result remained as the independent predictor of HPV persistence on a multivariate logistic regression (OR 0.43; 95% CI 0.21-0.87; p = 0.019).Conclusions: A low risk of HPV persistence was found among every HPV genotype in women undergoing cervical excision for pre-invasive cervical lesions. Initial cervical cytology result was the only independent predictor of HPV clearance during surveillance, which indicates the prognostic value of Pap test in primary HPV screening.C1 [Kilic, Derya; Guler, Tolga; Atigan, Ayhan; Avsaroglu, Elif; Kaleli, Babur] Pamukkale Univ, Dept Obstet & Gynecol, Med Sch, Denizli, Turkey.[Karakaya, Yeliz Arman] Pamukkale Univ, Dept Pathol, Med Sch, Denizli, Turkey.[Kaleli, Ilknur] Pamukkale Univ, Dept Microbiol, Med Sch, Denizli, Turkey

Predictors of Human papillomavirus (HPV) persistence after treatment of high grade cervical lesions; does cervical cytology have any prognostic value in primary HPV screening?

OBJECTIVE: This study aimed to determine the factors associated with Human Papillomavirus (HPV) persistence in women undergoing cervical excision for pre-invasive lesions, after they have been referred from a primary HPV screening program. METHODS: A retrospective study design involving patients who were treated at a Cervical Disease Screening and Treatment Unit, in a university hospital setting. After initial treatment, cervical HPV infection status was analyzed at the sixth month, first year and then subsequently after the second year. RESULTS: Totally, 395 patients who were diagnosed with pre-invasive cervical lesions and who subsequently undergone cervical excision were identified. In the first-year visit after cervical excision, HPV 18 was cleared in almost all (95.8%) cases, followed by HPV 16 (69.9%) and other hrHPV types (65.6%). Available data documented that 88.6% of women reached clearance after the two-year follow-up. Univariate analysis revealed a significantly higher proportion of HPV clearance among women who were younger (p = 0.019), premenopausal (p = 0.002), and who had been found to have a negative cytology result on their initial Pap test (p = 0.018). However, only cervical cytology result remained as the independent predictor of HPV persistence on a multivariate logistic regression (OR 0.43; 95% CI 0.21-0.87; p = 0.019). CONCLUSIONS: A low risk of HPV persistence was found among every HPV genotype in women undergoing cervical excision for pre-invasive cervical lesions. Initial cervical cytology result was the only independent predictor of HPV clearance during surveillance, which indicates the prognostic value of Pap test in primary HPV screening

Predictors of Human papillomavirus (HPV) persistence after treatment of high grade cervical lesions; does cervical cytology have any prognostic value in primary HPV screening?

Objective: This study aimed to determine the factors associated with Human Papillomavirus (HPV) persistence in women undergoing cervical excision for pre-invasive lesions, after they have been referred from a primary HPV screening program. Methods: A retrospective study design involving patients who were treated at a Cervical Disease Screening and Treatment Unit, in a university hospital setting. After initial treatment, cervical HPV infection status was analyzed at the sixth month, first year and then subsequently after the second year. Results: Totally, 395 patients who were diagnosed with pre-invasive cervical lesions and who subsequently undergone cervical excision were identified. In the first-year visit after cervical excision, HPV 18 was cleared in almost all (95.8%) cases, followed by HPV 16 (69.9%) and other hrHPV types (65.6%). Available data documented that 88.6% of women reached clearance after the two-year follow-up. Univariate analysis revealed a significantly higher proportion of HPV clearance among women who were younger (p = 0.019), premenopausal (p = 0.002), and who had been found to have a negative cytology result on their initial Pap test (p = 0.018). However, only cervical cytology result remained as the independent predictor of HPV persistence on a multivariate logistic regression (OR 0.43; 95% CI 0.21–0.87; p = 0.019). Conclusions: A low risk of HPV persistence was found among every HPV genotype in women undergoing cervical excision for pre-invasive cervical lesions. Initial cervical cytology result was the only independent predictor of HPV clearance during surveillance, which indicates the prognostic value of Pap test in primary HPV screening. © 2020 Elsevier Inc