3 research outputs found
SYNTHESIS OF 1,4-DISUBSTITUTED ISOQUINOLINES AS CHERYLLINE DERIVATIVES
No full textSynthetic studies of aryl-l,2,3,4-tetrahydroisoquinolines have attracted much attention from the synthetic community owing to the potential biological activities of this class of compounds and their increasing medicinal interest. The alkaloid cherylline is a naturally occurring optically active, 4-aryl-1,2,3,4- tetrahydroisoquinoline alkaloid, isolated from Crinum Powellii, Amaryllidaceae plant. There are many ways for cherylline synthesis. An application of Bischler-Napieralski reaction for the synthesis of new 1,4-disubstituted- 1,2,3,4- tetrahydroisoquinolines as cherylline derivatives, is described
A brief review of Cherylline synthesis
No full text1301-13201,2,3,4-Tetrahydroisoquinolines are an important
class of synthetic and natural compounds, which display a broad range of
medicinal activities. The 1,2,3,4-tetrahydroisoquinoline system has attracted
attention not only because of its biological activities, but also due to its
presence as a basic framework in many naturally occurring products and drugs.
Their skeletons are unique among the Amaryllidaceae alkaloids and they have
long been alluring targets for synthetic chemists as witnessed by a number of
articles dealing with biogenesis, isolation, characterization and synthesis.
The alkaloid cherylline is an optically active naturally occurring,
4-phenyl-1,2,3,4-tetrahydroisoquinoline alkaloid, isolated from Crinum
powelli, Amaryllidaceae plant. There are many ways for cherylline
synthesis. In this short review is described the different methods for
synthesis of the alkaloid cherylline
