428 research outputs found
Peceneaga-Camena Fault: Geomagnetic insights into active tectonic contact
Highly detailed, very accurate ground magnetic investigations were jointly conducted by Romanian and Ukrainian researchers on a segment of the Peceneaga-Camenas Fault (PCF) in order to reveal the potential of geomagnetic method for active faults investigating. The survey succeeded to outline the PCF track in the area covered by recent sediments, and provide insights on the fault structure and in-depth development. 2D numerical modeling has been employed for interpreting the obtained geomagnetic anomaly. Lateral variations in magnetization, as suggested by the model, reveal the complex geological architecture in the area, hidden by recent deposits. The zero magnetization outlined in the central part of the survey lines has been interpreted in geodynamic terms, as a breccias zone created along PCF track by its active dynamics
Non-linear Simulations of MHD Instabilities in Tokamaks Including Eddy Current Effects and Perspectives for the Extension to Halo Currents
The dynamics of large scale plasma instabilities can strongly be influenced
by the mutual interaction with currents flowing in conducting vessel
structures. Especially eddy currents caused by time-varying magnetic
perturbations and halo currents flowing directly from the plasma into the walls
are important. The relevance of a resistive wall model is directly evident for
Resistive Wall Modes (RWMs) or Vertical Displacement Events (VDEs). However,
also the linear and non-linear properties of most other large-scale
instabilities may be influenced significantly by the interaction with currents
in conducting structures near the plasma. The understanding of halo currents
arising during disruptions and VDEs, which are a serious concern for ITER as
they may lead to strong asymmetric forces on vessel structures, could also
benefit strongly from these non-linear modeling capabilities. Modeling the
plasma dynamics and its interaction with wall currents requires solving the
magneto-hydrodynamic (MHD) equations in realistic toroidal X-point geometry
consistently coupled with a model for the vacuum region and the resistive
conducting structures. With this in mind, the non-linear finite element MHD
code JOREK has been coupled with the resistive wall code STARWALL, which allows
to include the effects of eddy currents in 3D conducting structures in
non-linear MHD simulations. This article summarizes the capabilities of the
coupled JOREK-STARWALL system and presents benchmark results as well as first
applications to non-linear simulations of RWMs, VDEs, disruptions triggered by
massive gas injection, and Quiescent H-Mode. As an outlook, the perspectives
for extending the model to halo currents are described.Comment: Proceeding paper for Theory of Fusion Plasmas (Joint Varenna-Lausanne
International Workshop), Varenna, Italy (September 1-5, 2014); accepted for
publication in: to Journal of Physics: Conference Serie
Fedosov Quantization of Lagrange-Finsler and Hamilton-Cartan Spaces and Einstein Gravity Lifts on (Co) Tangent Bundles
We provide a method of converting Lagrange and Finsler spaces and their
Legendre transforms to Hamilton and Cartan spaces into almost Kaehler
structures on tangent and cotangent bundles. In particular cases, the Hamilton
spaces contain nonholonomic lifts of (pseudo) Riemannian / Einstein metrics on
effective phase spaces. This allows us to define the corresponding Fedosov
operators and develop deformation quantization schemes for nonlinear mechanical
and gravity models on Lagrange- and Hamilton-Fedosov manifolds.Comment: latex2e, 11pt, 35 pages, v3, accepted to J. Math. Phys. (2009
Teleparallel Lagrange Geometry and a Unified Field Theory
In this paper, we construct a field theory unifying gravity and
electromagnetism in the context of Extended Absolute Parallelism (EAP-)
geometry. This geometry combines, within its structure, the geometric richness
of the tangent bundle and the mathematical simplicity of Absolute Parallelism
(AP-) geometry. The constructed field theory is a generalization of the
Generalized Field Theory (GFT) formulated by Mikhail and Wanas. The theory
obtained is purely geometric. The horizontal (resp. vertical) field equations
are derived by applying the Euler-Lagrange equations to an appropriate
horizontal (resp. vertical) scalar Lagrangian. The symmetric part of the
resulting horizontal (resp. vertical) field equations gives rise to a
generalized form of Einstein's field equations in which the horizontal (resp.
vertical) energy-momentum tensor is purely geometric. The skew-symmetric part
of the resulting horizontal (resp. vertical) field equations gives rise to a
generalized form of Maxwell equations in which the electromagnetic field is
purely geometric. Some interesting special cases, which reveal the role of the
nonlinear connection in the obtained field equations, are examined. Finally,
the condition under which our constructed field equations reduce to the GFT is
explicitly established.Comment: Latex file, 33 page
Nonholonomic Ricci Flows, Exact Solutions in Gravity, and Symmetric and Nonsymmetric Metrics
We provide a proof that nonholonomically constrained Ricci flows of (pseudo)
Riemannian metrics positively result into nonsymmetric metrics (as explicit
examples, we consider flows of some physically valuable exact solutions in
general relativity). There are constructed and analyzed three classes of
solutions of Ricci flow evolution equations defining nonholonomic deformations
of Taub NUT, Schwarzschild, solitonic and pp--wave symmetric metrics into
nonsymmetric ones.Comment: latex2e, 12pt, 40 pages, version 2 with minor modifications, to be
published in Int. J. Theor. Phy
Ceruloplasmin Protects Against Rotenone-Induced Oxidative Stress and Neurotoxicity
To clarify the neuroprotective property of ceruloplasmin and the pathogenesis of aceruloplasminemia, we generated ceruloplasmin-deficient (CPā/ā) mice on the C57BL/10 genetic background and further treated them with a mitochondrial complex I inhibitor, rotenone. There was no iron accumulation in the brains of CPā/ā mice at least up to 60Ā weeks of age. Without rotenone treatment, CPā/ā mice showed slight motor dysfunction compared with CP+/+ mice, but there were no detectable differences in the levels of oxidative stress markers between these two groups. A low dose of rotenone did not affect the mitochondrial complex I activity in our mice, however, it caused a significant change in motor behavior, neuropathology, or the levels of oxidative stress markers in CPā/ā mice, but not in CP+/+ mice. Our data support that ceruloplasmin protects against rotenone-induced oxidative stress and neurotoxicity, probably through its antioxidant properties independently of its function of iron metabolism
Epigenetic Analysis of KSHV Latent and Lytic Genomes
Epigenetic modifications of the herpesviral genome play a key role in the transcriptional control of latent and lytic genes during a productive viral lifecycle. In this study, we describe for the first time a comprehensive genome-wide ChIP-on-Chip analysis of the chromatin associated with the Kaposi's sarcoma-associated herpesvirus (KSHV) genome during latency and lytic reactivation. Depending on the gene expression class, different combinations of activating [acetylated H3 (AcH3) and H3K4me3] and repressive [H3K9me3 and H3K27me3] histone modifications are associated with the viral latent genome, which changes upon reactivation in a manner that is correlated with their expression. Specifically, both the activating marks co-localize on the KSHV latent genome, as do the repressive marks. However, the activating and repressive histone modifications are mutually exclusive of each other on the bulk of the latent KSHV genome. The genomic region encoding the IE genes ORF50 and ORF48 possesses the features of a bivalent chromatin structure characterized by the concomitant presence of the activating H3K4me3 and the repressive H3K27me3 marks during latency, which rapidly changes upon reactivation with increasing AcH3 and H3K4me3 marks and decreasing H3K27me3. Furthermore, EZH2, the H3K27me3 histone methyltransferase of the Polycomb group proteins (PcG), colocalizes with the H3K27me3 mark on the entire KSHV genome during latency, whereas RTA-mediated reactivation induces EZH2 dissociation from the genomic regions encoding IE and E genes concurrent with decreasing H3K27me3 level and increasing IE/E lytic gene expression. Moreover, either the inhibition of EZH2 expression by a small molecule inhibitor DZNep and RNAi knockdown, or the expression of H3K27me3-specific histone demethylases apparently induced the KSHV lytic gene expression cascade. These data indicate that histone modifications associated with the KSHV latent genome are involved in the regulation of latency and ultimately in the control of the temporal and sequential expression of the lytic gene cascade. In addition, the PcG proteins play a critical role in the control of KSHV latency by maintaining a reversible heterochromatin on the KSHV lytic genes. Thus, the regulation of the spatial and temporal association of the PcG proteins with the KSHV genome may be crucial for propagating the KSHV lifecycle
Characterization of Oxidative Guanine Damage and Repair in Mammalian Telomeres
8-oxo-7,8-dihydroguanine (8-oxoG) and 2,6-diamino-4-hydroxy-5-formamidopyrimidine (FapyG) are among the most common oxidative DNA lesions and are substrates for 8-oxoguanine DNA glycosylase (OGG1)āinitiated DNA base excision repair (BER). Mammalian telomeres consist of triple guanine repeats and are subject to oxidative guanine damage. Here, we investigated the impact of oxidative guanine damage and its repair by OGG1 on telomere integrity in mice. The mouse cells were analyzed for telomere integrity by telomere quantitative fluorescence in situ hybridization (telomereāFISH), by chromosome orientationāFISH (COāFISH), and by indirect immunofluorescence in combination with telomereāFISH and for oxidative base lesions by Fpg-incision/Southern blot assay. In comparison to the wild type, telomere lengthening was observed in Ogg1 null (Ogg1ā/ā) mouse tissues and primary embryonic fibroblasts (MEFs) cultivated in hypoxia condition (3% oxygen), whereas telomere shortening was detected in Ogg1ā/ā mouse hematopoietic cells and primary MEFs cultivated in normoxia condition (20% oxygen) or in the presence of an oxidant. In addition, telomere length abnormalities were accompanied by altered telomere sister chromatid exchanges, increased telomere single- and double-strand breaks, and preferential telomere lagging- or G-strand losses in Ogg1ā/ā mouse cells. Oxidative guanine lesions were increased in telomeres in Ogg1ā/ā mice with aging and primary MEFs cultivated in 20% oxygen. Furthermore, oxidative guanine lesions persisted at high level in Ogg1ā/ā MEFs after acute exposure to hydrogen peroxide, while they rapidly returned to basal level in wild-type MEFs. These findings indicate that oxidative guanine damage can arise in telomeres where it affects length homeostasis, recombination, DNA replication, and DNA breakage repair. Our studies demonstrate that BER pathway is required in repairing oxidative guanine damage in telomeres and maintaining telomere integrity in mammals
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